Lyell's syndrome associated with the use of topical agents: case report
- 1Hospital Regional Honorio Delgado Espinoza, Arequipa, Peru. Hospital Regional Honorio Delgado Espinoza Arequipa Peru
- 2Universidad Católica de Santa María, Arequipa, Peru. Universidad Católica de Santa María Universidad Católica de Santa María Arequipa Peru
Abstract
Lyell's syndrome (LS) is a severe drug-induced cutaneous adverse reaction, associated with high morbidity and mortality. We present the case of a 41-year-old male who, after the use of topical medications, developed fever, maculopapular lesions, ocular and mucosal involvement, with affectation of more than 30% of the body surface area. Cutaneous biopsy ruled out other pathologies. Management included systemic methylprednisolone, aluminum subacetate, topical mupirocin, ophthalmic prednisolone, and ophthalmic hypromellose, with a favorable outcome and without complications. This case highlights the importance of considering topical medications as possible triggers for LS, as well as the need for early diagnosis and timely management. Early identification and a multidisciplinary therapeutic approach are fundamental to improve clinical outcomes and reduce the morbidity and mortality associated with this entity.
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BibTeX
@article{murillosalas2026lyells,
title = {{Lyell's syndrome associated with the use of topical agents: case report}},
author = {Alan P. Murillo-Salas and Estephania B. Díaz-Panuera and Francheska M. Núñez-Gonzales and Aira S. Chávez-Panuera and Fabián L. Cuba-Pacheco and María F. Bernales-Valdivia},
journal = {Revista Peruana de Medicina Experimental y Salud Publica},
year = {2026},
month = aug,
doi = {10.17843/rpmesp.2026.433.15468},
url = {https://doi.org/10.17843/rpmesp.2026.433.15468},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Lyell's syndrome associated with the use of topical agents: case report
AU - Alan P. Murillo-Salas
AU - Estephania B. Díaz-Panuera
AU - Francheska M. Núñez-Gonzales
AU - Aira S. Chávez-Panuera
AU - Fabián L. Cuba-Pacheco
AU - María F. Bernales-Valdivia
PY - 2026
DA - 2026/08/04
JO - Revista Peruana de Medicina Experimental y Salud Publica
DO - 10.17843/rpmesp.2026.433.15468
UR - https://doi.org/10.17843/rpmesp.2026.433.15468
AB - Lyell's syndrome (LS) is a severe drug-induced cutaneous adverse reaction, associated with high morbidity and mortality. We present the case of a 41-year-old male who, after the use of topical medications, developed fever, maculopapular lesions, ocular and mucosal involvement, with affectation of more than 30% of the body surface area. Cutaneous biopsy ruled out other pathologies. Management included systemic methylprednisolone, aluminum subacetate, topical mupirocin, ophthalmic prednisolone, and ophthalmic hypromellose, with a favorable outcome and without complications. This case highlights the importance of considering topical medications as possible triggers for LS, as well as the need for early diagnosis and timely management. Early identification and a multidisciplinary therapeutic approach are fundamental to improve clinical outcomes and reduce the morbidity and mortality associated with this entity.
SN - 1726-4634
SN - 1726-4642
ER -