Concurrent Immune-related Enteritis and Cytomegalovirus Enteritis during Immune Checkpoint Inhibitor Therapy
Abstract
Immune checkpoint inhibitors (ICIs) are widely used for advanced lung cancer; however, isolated ileitis and subsequent perforation are rare, particularly when complicated by cytomegalovirus (CMV) infection.A woman in her 50s with stage IV lung adenocarcinoma developed ICI-associated enteritis after atezolizumab-based therapy, which partially improved with corticosteroids and infliximab, but she later experienced ileal perforation following second-line chemotherapy. A histopathological examination revealed ICI-induced enteritis with cytomegalovirus (CMV) inclusions. Despite antiviral therapy with ganciclovir, the patient died. We present the first report of pathologically confirmed ICI-induced ileitis complicated by CMV enteritis in resected small bowel tissue.
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BibTeX
@article{yamada2026concurrent,
title = {{Concurrent Immune-related Enteritis and Cytomegalovirus Enteritis during Immune Checkpoint Inhibitor Therapy}},
author = {Yuka Yamada and Norio Kodaka and Saeko Shinozawa and Yuki Yokouchi and Hiroto Matsuse},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.7426-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7426-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Concurrent Immune-related Enteritis and Cytomegalovirus Enteritis during Immune Checkpoint Inhibitor Therapy
AU - Yuka Yamada
AU - Norio Kodaka
AU - Saeko Shinozawa
AU - Yuki Yokouchi
AU - Hiroto Matsuse
PY - 2026
DA - 2026/08/25
JO - Internal Medicine
DO - 10.2169/internalmedicine.7426-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7426-26/_article
AB - Immune checkpoint inhibitors (ICIs) are widely used for advanced lung cancer; however, isolated ileitis and subsequent perforation are rare, particularly when complicated by cytomegalovirus (CMV) infection.A woman in her 50s with stage IV lung adenocarcinoma developed ICI-associated enteritis after atezolizumab-based therapy, which partially improved with corticosteroids and infliximab, but she later experienced ileal perforation following second-line chemotherapy. A histopathological examination revealed ICI-induced enteritis with cytomegalovirus (CMV) inclusions. Despite antiviral therapy with ganciclovir, the patient died. We present the first report of pathologically confirmed ICI-induced ileitis complicated by CMV enteritis in resected small bowel tissue.
SN - 1349-7235
SN - 0918-2918
ER -