Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 7 min ago
Peer-reviewedCC BYFrontiers in Pediatrics

Advances in fecal biomarkers for necrotizing enterocolitis

  • Xiaoting Wang1
  • Xiaoting Wang2
  • Jia Yin2
  • Tianhao Zhang1
  • Tianhao Zhang2
  • Xiaoli Yang2
  • Xiaoli Yang3
  • Jinsong Du2
  • Jinsong Du4
  • Ping Yang1
  • Ping Yang2
4 affiliations
  1. 1Department of Pediatric Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China
  2. 2Department of Pediatric Surgery, Suining Central Hospital, Suining, Sichuan, China
  3. 3Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, China
  4. 4School of Medicine and Life Science, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
Read full textDOICite

Abstract

Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease in neonatal period. Early identification and early intervention are of great significance to improve the prognosis of children. At present, the diagnosis of NEC mainly depends on clinical manifestations, laboratory indicators and abdominal imaging examinations. However, the early symptoms lack specificity, and the blood test has certain trauma. The typical imaging signs suggest that the disease progresses to the middle and late stages, and there is a certain lag. In recent years, with the deepening of the research on the pathogenesis and detection technology of NEC, fecal markers have attracted attention because they may reflect pathological changes within the intestinal lumen and support early prediction, diagnosis, severity assessment, and prognostic evaluation of NEC. Existing studies have shown that fecal inflammatory proteins, barrier and mucosal injury-related indicators, intestinal flora and metabolic indicators can change during the development of NEC, which may support early prediction, diagnosis, severity assessment and prognostic prediction of NEC. Based on the main pathological processes of NEC, this review summarizes the research progress and current limitations of fecal biomarkers and discusses their potential clinical applications in NEC.

Related

  1. Necrotizing Enterocolitis Secondary to Congenital Syphilis in an 18-Day-Old Neonate: Successful Treatment With Intravenous Penicillin.
    Chariya Chap, Vissotsak Bin, Sakviseth Bin
    Case reports in infectious diseasesPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  2. AhR ligands in necrotizing enterocolitis: a provisional evidence map of ligand-specific biology and translational considerations.
    Laurent Ferraris, Ioana Ferecatu, Julio Aires
    Gut microbesPeer-reviewedCC BYFull textGeneral medicineEurope PMCPMCDOAJ
  3. From sepsis to necrotizing enterocolitis with appendiceal perforation: a case report of successful salvage therapy with aztreonam–avibactam in an extremely preterm infant with NDM-producing Klebsiella pneumoniae
    Yang He, Jichong Huang, Bin Du +6
    Frontiers in PharmacologyPeer-reviewedCC BY 4.0Full textPharmacology & toxicologyCrossrefEurope PMCPMCEurope PMC
  4. β-glucan mitigates necrotizing enterocolitis-induced long-term cognitive impairment by remodeling gut microbiota and restoring tryptophan metabolite IAA-mediated gut–brain signaling
    Xingdao Zhang, Haiyan Cao, Yuni Zhang +1
    Gut MicrobesPeer-reviewedCC BYFull textGeneral medicineDOAJ
  5. Multicenter cohort of necrotizing enterocolitis in Latin America: evaluation of risk factors and clinical outcomes in Chilean Hospitals.
    Alejandra Sandoval C, Luis Delpiano M, Miguel Ángel Pantoja H +4
    Frontiers in pediatricsPeer-reviewedCC BYFull textGeneral medicineEurope PMCPMC

Cite

BibTeXRIS
BibTeX
@article{wang2026advances,
  title = {{Advances in fecal biomarkers for necrotizing enterocolitis}},
  author = {Xiaoting Wang and Xiaoting Wang and Jia Yin and Tianhao Zhang and Tianhao Zhang and Xiaoli Yang and Xiaoli Yang and Jinsong Du and Jinsong Du and Ping Yang and Ping Yang},
  journal = {Frontiers in Pediatrics},
  year = {2026},
  month = nov,
  doi = {10.3389/fped.2026.1994667},
  url = {https://doi.org/10.3389/fped.2026.1994667},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Advances in fecal biomarkers for necrotizing enterocolitis
AU  - Xiaoting Wang
AU  - Xiaoting Wang
AU  - Jia Yin
AU  - Tianhao Zhang
AU  - Tianhao Zhang
AU  - Xiaoli Yang
AU  - Xiaoli Yang
AU  - Jinsong Du
AU  - Jinsong Du
AU  - Ping Yang
AU  - Ping Yang
PY  - 2026
DA  - 2026/11/02
JO  - Frontiers in Pediatrics
DO  - 10.3389/fped.2026.1994667
UR  - https://doi.org/10.3389/fped.2026.1994667
AB  - Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease in neonatal period. Early identification and early intervention are of great significance to improve the prognosis of children. At present, the diagnosis of NEC mainly depends on clinical manifestations, laboratory indicators and abdominal imaging examinations. However, the early symptoms lack specificity, and the blood test has certain trauma. The typical imaging signs suggest that the disease progresses to the middle and late stages, and there is a certain lag. In recent years, with the deepening of the research on the pathogenesis and detection technology of NEC, fecal markers have attracted attention because they may reflect pathological changes within the intestinal lumen and support early prediction, diagnosis, severity assessment, and prognostic evaluation of NEC. Existing studies have shown that fecal inflammatory proteins, barrier and mucosal injury-related indicators, intestinal flora and metabolic indicators can change during the development of NEC, which may support early prediction, diagnosis, severity assessment and prognostic prediction of NEC. Based on the main pathological processes of NEC, this review summarizes the research progress and current limitations of fecal biomarkers and discusses their potential clinical applications in NEC.
SN  - 2296-2360
ER  -