Microbiological Spectrum and Antimicrobial Resistance Patterns in Tubo-Ovarian Abscesses Managed by Surgery or Drainage at a Tertiary Hospital in Vietnam: A Retrospective Case Series.
4 affiliations
- 1University of Medicine and Pharmacy Ho Chi Minh City Vietnam.
- 2Nhan Dan Gia Dinh Hospital Ho Chi Minh City Vietnam.
- 3Thu Duc Hospital Ho Chi Minh City Vietnam.
- 4Children's Hospital 1 Ho Chi Minh City Vietnam.
Abstract
Background and aims
Tubo-ovarian abscess requires empirical antimicrobial therapy before culture results are available, but local antimicrobial resistance data are limited in Vietnam. We described the microbiological spectrum and antimicrobial susceptibility patterns of tubo-ovarian abscesses managed by surgery or drainage.Methods
We conducted a single-center retrospective case series of 66 patients with tubo-ovarian abscess who underwent surgery or drainage and had procedure-obtained abscess material submitted for culture at Nhan Dan Gia Dinh Hospital from January 2021 to May 2025. Antimicrobial susceptibility data were summarized for recovered isolates when available. Descriptive statistics and Wilson 95% confidence intervals were used for key proportions. Antimicrobial susceptibility was summarized using the number of isolates tested for each agent as the denominator.Results
The analytic sample comprised 66 surgically treated or drained patients. Culture positivity was 43.9% (29/66; 95% CI, 32.6%-55.9%), with 39 bacterial isolates reported. Escherichia coli was the most frequent isolate (19/39, 48.7%), followed by Streptococcus spp. (9/39, 23.1%) and Klebsiella pneumoniae (7/39, 17.9%). Among E. coli isolates, 6/19 (31.6%) were extended-spectrum beta-lactamase producers and 1/19 (5.3%) was an AmpC producer. Resistance among tested E. coli isolates was 13/14 (92.9%) to ampicillin, 7/14 (50.0%) to ceftriaxone, and 10/19 (52.6%) to trimethoprim-sulfamethoxazole. Antibiotic-specific denominators were small and variable.Conclusion
Tubo-ovarian abscesses managed by surgery or drainage in this Vietnamese case series frequently yielded enteric Gram-negative organisms and streptococci, with substantial E. coli resistance to commonly used agents among tested isolates. These findings support procedure-obtained abscess culture, local antibiograms, clinically indicated anaerobic coverage, and antimicrobial stewardship; they should not be generalized to all patients with tubo-ovarian abscess.
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BibTeX
@article{thuong2026microbiological,
title = {{Microbiological Spectrum and Antimicrobial Resistance Patterns in Tubo-Ovarian Abscesses Managed by Surgery or Drainage at a Tertiary Hospital in Vietnam: A Retrospective Case Series.}},
author = {Bui Chi Thuong and Huynh Tan An and Pham Dinh Nguyen},
journal = {Health science reports},
year = {2026},
month = oct,
doi = {10.1002/hsr2.73414},
url = {https://europepmc.org/article/MED/42936173},
note = {CC BY},
}
RIS
TY - JOUR
TI - Microbiological Spectrum and Antimicrobial Resistance Patterns in Tubo-Ovarian Abscesses Managed by Surgery or Drainage at a Tertiary Hospital in Vietnam: A Retrospective Case Series.
AU - Bui Chi Thuong
AU - Huynh Tan An
AU - Pham Dinh Nguyen
PY - 2026
DA - 2026/10/26
JO - Health science reports
DO - 10.1002/hsr2.73414
UR - https://europepmc.org/article/MED/42936173
AB - Background and aims Tubo-ovarian abscess requires empirical antimicrobial therapy before culture results are available, but local antimicrobial resistance data are limited in Vietnam. We described the microbiological spectrum and antimicrobial susceptibility patterns of tubo-ovarian abscesses managed by surgery or drainage.Methods We conducted a single-center retrospective case series of 66 patients with tubo-ovarian abscess who underwent surgery or drainage and had procedure-obtained abscess material submitted for culture at Nhan Dan Gia Dinh Hospital from January 2021 to May 2025. Antimicrobial susceptibility data were summarized for recovered isolates when available. Descriptive statistics and Wilson 95% confidence intervals were used for key proportions. Antimicrobial susceptibility was summarized using the number of isolates tested for each agent as the denominator.Results The analytic sample comprised 66 surgically treated or drained patients. Culture positivity was 43.9% (29/66; 95% CI, 32.6%-55.9%), with 39 bacterial isolates reported. Escherichia coli was the most frequent isolate (19/39, 48.7%), followed by Streptococcus spp. (9/39, 23.1%) and Klebsiella pneumoniae (7/39, 17.9%). Among E. coli isolates, 6/19 (31.6%) were extended-spectrum beta-lactamase producers and 1/19 (5.3%) was an AmpC producer. Resistance among tested E. coli isolates was 13/14 (92.9%) to ampicillin, 7/14 (50.0%) to ceftriaxone, and 10/19 (52.6%) to trimethoprim-sulfamethoxazole. Antibiotic-specific denominators were small and variable.Conclusion Tubo-ovarian abscesses managed by surgery or drainage in this Vietnamese case series frequently yielded enteric Gram-negative organisms and streptococci, with substantial E. coli resistance to commonly used agents among tested isolates. These findings support procedure-obtained abscess culture, local antibiograms, clinically indicated anaerobic coverage, and antimicrobial stewardship; they should not be generalized to all patients with tubo-ovarian abscess.
SN - 2398-8835
ER -