Incidence and associated factors of early postoperative dry eye disease after SPT-TransPRK
- 1Department of Ophthalmology，the Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
Abstract
ObjectiveTo investigate early postoperative changes in ocular surface parameters and the incidence of dry eye disease (DED) after smart pulse technology-assisted transepithelial photorefractive keratectomy (SPT-TransPRK), and to analyze the associated factors. MethodsThis single-center prospective cohort study included 52 patients (52 eyes) without preoperative DED who underwent SPT-TransPRK at the Third Affiliated Hospital of Sun Yat-sen University between November 2024 and March 2025. Assessments were performed preoperatively and at 2 weeks and 1-, 2-, and 3- months postoperatively, including the Ocular Surface Disease Index (OSDI) score, first noninvasive tear film breakup time (NIBUTf), corneal fluorescein staining score based on the National Eye Institute (NEI) scale, Schirmer Ⅰ test (SIT), tear meniscus height (TMH), ocular redness index, and meiboscore. The incidence of postoperative DED and its associated factors were analyzed. ResultsThe incidences of DED at 2 weeks and 1-, 2-, and 3- months postoperatively were 57.7%, 36.5%, 9.6%, and 9.6%, respectively. Significant overall differences across follow-up time points were observed in the OSDI score, NIBUTf, and NEI score (all P ＜ 0.05), whereas no significant overall differences were observed in SIT, TMH, or the ocular redness index (all P ＞ 0.05). Postoperative DED incidence and changes in most ocular surface parameters did not differ significantly between groups stratified by preoperative meiboscore. A higher preoperative OSDI score was independently associated with DED at 2 weeks postoperatively (OR = 1.120, 95%CI: 1.001-1.253, P = 0.048), whereas a larger ablation zone diameter was independently associated with DED at 1 month postoperatively (OR = 1.987, 95%CI: 1.100-3.590, P = 0.023). Ablation zone diameter was positively correlated with the OSDI score at 1 month postoperatively (rs = 0.325, P = 0.019). ConclusionsDED after SPT-TransPRK occurred predominantly in the early postoperative period and gradually resolved in most patients. The preoperative OSDI score and ablation zone diameter may help identify patients at risk of early postoperative DED.
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BibTeX
@article{haocheng2026incidence,
title = {{Incidence and associated factors of early postoperative dry eye disease after SPT-TransPRK}},
author = {Haocheng ZHU and Yanzhuo CHEN and Yanqun LI and Shiqi LING},
journal = {Xin yixue},
year = {2026},
month = oct,
doi = {10.12464/j.issn.0253-9802.2026-0746},
url = {https://doi.org/10.12464/j.issn.0253-9802.2026-0746},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Incidence and associated factors of early postoperative dry eye disease after SPT-TransPRK
AU - Haocheng ZHU
AU - Yanzhuo CHEN
AU - Yanqun LI
AU - Shiqi LING
PY - 2026
DA - 2026/10/28
JO - Xin yixue
DO - 10.12464/j.issn.0253-9802.2026-0746
UR - https://doi.org/10.12464/j.issn.0253-9802.2026-0746
AB - ObjectiveTo investigate early postoperative changes in ocular surface parameters and the incidence of dry eye disease (DED) after smart pulse technology-assisted transepithelial photorefractive keratectomy (SPT-TransPRK), and to analyze the associated factors. MethodsThis single-center prospective cohort study included 52 patients (52 eyes) without preoperative DED who underwent SPT-TransPRK at the Third Affiliated Hospital of Sun Yat-sen University between November 2024 and March 2025. Assessments were performed preoperatively and at 2 weeks and 1-, 2-, and 3- months postoperatively, including the Ocular Surface Disease Index (OSDI) score, first noninvasive tear film breakup time (NIBUTf), corneal fluorescein staining score based on the National Eye Institute (NEI) scale, Schirmer Ⅰ test (SIT), tear meniscus height (TMH), ocular redness index, and meiboscore. The incidence of postoperative DED and its associated factors were analyzed. ResultsThe incidences of DED at 2 weeks and 1-, 2-, and 3- months postoperatively were 57.7%, 36.5%, 9.6%, and 9.6%, respectively. Significant overall differences across follow-up time points were observed in the OSDI score, NIBUTf, and NEI score (all P ＜ 0.05), whereas no significant overall differences were observed in SIT, TMH, or the ocular redness index (all P ＞ 0.05). Postoperative DED incidence and changes in most ocular surface parameters did not differ significantly between groups stratified by preoperative meiboscore. A higher preoperative OSDI score was independently associated with DED at 2 weeks postoperatively (OR = 1.120, 95%CI: 1.001-1.253, P = 0.048), whereas a larger ablation zone diameter was independently associated with DED at 1 month postoperatively (OR = 1.987, 95%CI: 1.100-3.590, P = 0.023). Ablation zone diameter was positively correlated with the OSDI score at 1 month postoperatively (rs = 0.325, P = 0.019). ConclusionsDED after SPT-TransPRK occurred predominantly in the early postoperative period and gradually resolved in most patients. The preoperative OSDI score and ablation zone diameter may help identify patients at risk of early postoperative DED.
SN - 0253-9802
ER -