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Peer-reviewedCC BYJournal of Clinical Medicine Research

Klotho Gene Single-Nucleotide Polymorphism and Proteinuria in a General Population

  • Masato Hamasaki1
  • Kazuhiko Kotani1
  • Yoshitaka Iwazu2
  • Makoto Kuro-o3
  1. 1Center for Community Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan
  2. 2Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan
  3. 3Division of Mineral Metabolism, Center for Molecular Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan
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Abstract

Background: Chronic kidney disease (CKD) is a major condition with a substantial sociomedical and economic burden. Klotho plays a role in renal protection via its antioxidant and anti-inflammatory properties. Proteinuria is an early indicator of CKD. Although experimental studies have demonstrated the biological effects of Klotho in CKD, its clinical relevance to proteinuria remains unclear.

Methods: The present study investigated the association between the A/T alleles of the Klotho gene rs650439 single-nucleotide polymorphism (SNP) and proteinuria in a general Japanese population. Clinical and genotyping data from a total of 916 community-dwelling participants (mean age = 63 years old) were analyzed.

Results: Participants carrying the minor TT genotype accounted for 13.2% of the population. The prevalence of proteinuria was significantly higher in the TT group than in the AA + AT group (15.7% vs. 7.3%, P < 0.01). Logistic regression analysis showed that the TT genotype was significantly associated with proteinuria (crude odds ratio (OR) = 2.37, 95% confidence interval (CI) 1.35–4.14). This association remained significant after adjustment for age, sex, and cardiometabolic factors (adjusted OR = 2.07, 95% CI 1.14–3.77).

Conclusions: These findings suggest that the TT genotype of Klotho gene rs650439 SNP may serve as a genetic marker for early renal proteinuria. Further research is required to confirm the findings.

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Cite

BibTeXRIS
BibTeX
@article{hamasaki2026klotho,
  title = {{Klotho Gene Single-Nucleotide Polymorphism and Proteinuria in a General Population}},
  author = {Masato Hamasaki and Kazuhiko Kotani and Yoshitaka Iwazu and Makoto Kuro-o},
  journal = {Journal of Clinical Medicine Research},
  year = {2026},
  month = oct,
  doi = {10.14740/jocmr6669},
  url = {https://europepmc.org/article/PMC/PMC13719641},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Klotho Gene Single-Nucleotide Polymorphism and Proteinuria in a General Population
AU  - Masato Hamasaki
AU  - Kazuhiko Kotani
AU  - Yoshitaka Iwazu
AU  - Makoto Kuro-o
PY  - 2026
DA  - 2026/10/01
JO  - Journal of Clinical Medicine Research
DO  - 10.14740/jocmr6669
UR  - https://europepmc.org/article/PMC/PMC13719641
AB  - Background: Chronic kidney disease (CKD) is a major condition with a substantial sociomedical and economic burden. Klotho plays a role in renal protection via its antioxidant and anti-inflammatory properties. Proteinuria is an early indicator of CKD. Although experimental studies have demonstrated the biological effects of Klotho in CKD, its clinical relevance to proteinuria remains unclear.  Methods: The present study investigated the association between the A/T alleles of the Klotho gene rs650439 single-nucleotide polymorphism (SNP) and proteinuria in a general Japanese population. Clinical and genotyping data from a total of 916 community-dwelling participants (mean age = 63 years old) were analyzed.  Results: Participants carrying the minor TT genotype accounted for 13.2% of the population. The prevalence of proteinuria was significantly higher in the TT group than in the AA + AT group (15.7% vs. 7.3%, P < 0.01). Logistic regression analysis showed that the TT genotype was significantly associated with proteinuria (crude odds ratio (OR) = 2.37, 95% confidence interval (CI) 1.35–4.14). This association remained significant after adjustment for age, sex, and cardiometabolic factors (adjusted OR = 2.07, 95% CI 1.14–3.77).  Conclusions: These findings suggest that the TT genotype of Klotho gene rs650439 SNP may serve as a genetic marker for early renal proteinuria. Further research is required to confirm the findings.
SN  - 1918-3003
SN  - 1918-3011
ER  -