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Peer-reviewedCC BY 4.0Health Science Reports

Association of Vascular Endothelial Growth Factor A +936 C/T Polymorphism With Non‐Alcoholic Fatty Liver Disease in a Bangladeshi Population: A Case‐Control Study

  • Rakibul Hasan Shanto1,2
  • Imran Hossain1,3
  • Ahmad Niaz Rahman1,3
  • Fazle Rabbi1
  • Anik Dhar1
  • Sheikh Faisal Asadullah Mahdi1
  • Tarhima Jahan Jerin4
  • Md. Samsul Arafin5
  • Mamun Al Mahtab6
  • Sheikh Zahir Raihan1
6 affiliations
  1. 1Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy University of Dhaka Dhaka Bangladesh
  2. 2Department of Pharmacy, Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore Bangladesh
  3. 3Department of Pharmacy University of Asia Pacific Dhaka Bangladesh
  4. 4Department of Biotechnology, Faculty of Agriculture Bangladesh Agricultural University Mymensingh Bangladesh
  5. 5Department of Hepatology Sher‐E‐Bangla Medical College Hospital Barishal Bangladesh
  6. 6Department of Hepatology Bangladesh Medical University Dhaka Bangladesh
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Abstract

Background and Aims: Non‐Alcoholic Fatty Liver Disease (NAFLD) ranges from hepatic steatosis to advanced cirrhosis. Polymorphisms in the vascular endothelial growth factor A (VEGFA) gene can change its expression, potentially altering angiogenesis and advancing disease stage. This study aimed to evaluate the association between the VEGFA +936 C/T polymorphism and susceptibility to NAFLD in a Bangladeshi population.

Methods: A case‐control study was conducted including 100 NAFLD patients and 100 controls. NAFLD was diagnosed by ultrasonography. Genotyping was performed using allele‐specific polymerase chain reaction followed by gel electrophoresis. Biochemical parameters were measured using standard enzymatic methods following the manufacturer's instructions.

Results: The frequency of the T allele was significantly higher in NAFLD patients compared to controls (22.5% vs. 12%). The control genotype distribution was consistent with Hardy‐Weinberg equilibrium (χ 2 = 0.2812, p = 0.60). The Cochran–Armitage trend test indicated an association between increasing T‐allele dosage and NAFLD (Z = 2.68, p = 0.007). In logistic regression, the T‐allele was associated with NAFLD in the crude additive model (OR = 2.05, 95% CI: 1.20–3.51, p = 0.009) and after adjustment for age, sex, BMI, and fasting blood glucose (OR = 2.14, 95% CI: 1.13–4.08, p = 0.02). Under the dominant model, the association remained significant in both crude (OR = 2.27, 95% CI: 1.22–4.22, p = 0.01) and adjusted analyses (OR = 2.51, 95% CI: 1.18–5.33, p = 0.02). NAFLD patients showed significantly higher blood pressure, fasting blood glucose, HbA1c, total cholesterol, ALT, and AST, with lower HDL, while body mass index didn't differ significantly between groups.

Conclusion: This study demonstrated a significant association between the VEGFA +936 C/T polymorphism and susceptibility to NAFLD in a Bangladeshi population. However, due to the small sample size and limited number of TT individuals, further large‐scale and functional studies are required to validate these findings.

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Cite

BibTeXRIS
BibTeX
@article{shanto2026association,
  title = {{Association of Vascular Endothelial Growth Factor A +936 C/T Polymorphism With Non‐Alcoholic Fatty Liver Disease in a Bangladeshi Population: A Case‐Control Study}},
  author = {Rakibul Hasan Shanto and Imran Hossain and Ahmad Niaz Rahman and Fazle Rabbi and Anik Dhar and Sheikh Faisal Asadullah Mahdi and Tarhima Jahan Jerin and Md. Samsul Arafin and Mamun Al Mahtab and Sheikh Zahir Raihan},
  journal = {Health Science Reports},
  year = {2026},
  month = nov,
  doi = {10.1002/hsr2.73494},
  url = {https://doi.org/10.1002/hsr2.73494},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Association of Vascular Endothelial Growth Factor A +936 C/T Polymorphism With Non‐Alcoholic Fatty Liver Disease in a Bangladeshi Population: A Case‐Control Study
AU  - Rakibul Hasan Shanto
AU  - Imran Hossain
AU  - Ahmad Niaz Rahman
AU  - Fazle Rabbi
AU  - Anik Dhar
AU  - Sheikh Faisal Asadullah Mahdi
AU  - Tarhima Jahan Jerin
AU  - Md. Samsul Arafin
AU  - Mamun Al Mahtab
AU  - Sheikh Zahir Raihan
PY  - 2026
DA  - 2026/11/05
JO  - Health Science Reports
DO  - 10.1002/hsr2.73494
UR  - https://doi.org/10.1002/hsr2.73494
AB  - Background and Aims: Non‐Alcoholic Fatty Liver Disease (NAFLD) ranges from hepatic steatosis to advanced cirrhosis. Polymorphisms in the vascular endothelial growth factor A (VEGFA) gene can change its expression, potentially altering angiogenesis and advancing disease stage. This study aimed to evaluate the association between the VEGFA +936 C/T polymorphism and susceptibility to NAFLD in a Bangladeshi population.  Methods: A case‐control study was conducted including 100 NAFLD patients and 100 controls. NAFLD was diagnosed by ultrasonography. Genotyping was performed using allele‐specific polymerase chain reaction followed by gel electrophoresis. Biochemical parameters were measured using standard enzymatic methods following the manufacturer's instructions.  Results: The frequency of the T allele was significantly higher in NAFLD patients compared to controls (22.5% vs. 12%). The control genotype distribution was consistent with Hardy‐Weinberg equilibrium (χ 2 = 0.2812, p = 0.60). The Cochran–Armitage trend test indicated an association between increasing T‐allele dosage and NAFLD (Z = 2.68, p = 0.007). In logistic regression, the T‐allele was associated with NAFLD in the crude additive model (OR = 2.05, 95% CI: 1.20–3.51, p = 0.009) and after adjustment for age, sex, BMI, and fasting blood glucose (OR = 2.14, 95% CI: 1.13–4.08, p = 0.02). Under the dominant model, the association remained significant in both crude (OR = 2.27, 95% CI: 1.22–4.22, p = 0.01) and adjusted analyses (OR = 2.51, 95% CI: 1.18–5.33, p = 0.02). NAFLD patients showed significantly higher blood pressure, fasting blood glucose, HbA1c, total cholesterol, ALT, and AST, with lower HDL, while body mass index didn't differ significantly between groups.  Conclusion: This study demonstrated a significant association between the VEGFA +936 C/T polymorphism and susceptibility to NAFLD in a Bangladeshi population. However, due to the small sample size and limited number of TT individuals, further large‐scale and functional studies are required to validate these findings.
SN  - 2398-8835
ER  -