Core–Sheath Nanofibers From a Modified Coaxial Electrospinning for Transdermal Delivery of Finasteride
5 affiliations
- 1Department of Urology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China
- 2Department of Urology Shanghai General Hospital Shanghai Jiao Tong University Shanghai China
- 3School of Materials and Chemistry University of Shanghai for Science and Technology Shanghai China
- 4Department of Science and Education Dongying People’s Hospital (Dongying Hospital of Shandong Provincial Hospital Group) Dongying China
- 5School of Information Science and Technology Sanda University Shanghai China
Abstract
Traditional blending electrospinning has a series of issues during implementation, and the corresponding monolithic nanofibers can always be updated through the intentional design of core-sheath nanostructures. In this study, a modified coaxial electrospinning approach was employed to refine the electrospinning process by eliminating abnormal phenomena, while simultaneously imparting core-sheath nanostructures and improved transdermal finasteride (FIN) delivery performance. Using an electrospinnable ethylcellulose (EC) solution containing FIN as the core fluid and an unspinnable polyvinylpyrrolidone (PVP)/sodium dodecyl sulfate (SDS) solution as the sheath fluid, medicated core-sheath nanofibers (E3) were fabricated continuously and robustly. The monolithic nanofibers (E2) from a conventional blending electrospinning were prepared as a comparison. FIN existed in an amorphous state within both E2 and E3 nanofibers, attributed to its excellent compatibility with EC. The sustained release profiles of nanofibers E2 and E3 are similar, but the penetration rates of FIN molecules from the nanofibers E2 and E3 always have significant differences from the initial tests at 0.5 h (10.32 ± 4.31% and 12.85 ± 5.14% for nanofibers E2 and E3, respectively) to the final tests at 4.0 h (38.16 ± 5.47% and 51.31 ± 5.19% for nanofibers E2 and E3, respectively). The mechanism underlying the robust preparation enabled by the unspinnable sheath fluid is proposed: it prevents multiple abnormal phenomena inherent to single-fluid blending processes. This protocol offers a versatile strategy to upgrade traditional single-fluid blending electrospinning products, endowing them with an improved functional performance.
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BibTeX
@article{sun2026coresheath,
title = {{Core–Sheath Nanofibers From a Modified Coaxial Electrospinning for Transdermal Delivery of Finasteride}},
author = {L L Sun and Yisa Zhao and Xiyu Caomeng and Deng‐Guang Yu and Ping Liu},
journal = {ChemistryOpen},
year = {2026},
month = jun,
doi = {10.1002/open.202500564},
url = {https://doi.org/10.1002/open.202500564},
note = {CC BY},
}
RIS
TY - JOUR
TI - Core–Sheath Nanofibers From a Modified Coaxial Electrospinning for Transdermal Delivery of Finasteride
AU - L L Sun
AU - Yisa Zhao
AU - Xiyu Caomeng
AU - Deng‐Guang Yu
AU - Ping Liu
PY - 2026
DA - 2026/06/01
JO - ChemistryOpen
DO - 10.1002/open.202500564
UR - https://doi.org/10.1002/open.202500564
AB - Traditional blending electrospinning has a series of issues during implementation, and the corresponding monolithic nanofibers can always be updated through the intentional design of core-sheath nanostructures. In this study, a modified coaxial electrospinning approach was employed to refine the electrospinning process by eliminating abnormal phenomena, while simultaneously imparting core-sheath nanostructures and improved transdermal finasteride (FIN) delivery performance. Using an electrospinnable ethylcellulose (EC) solution containing FIN as the core fluid and an unspinnable polyvinylpyrrolidone (PVP)/sodium dodecyl sulfate (SDS) solution as the sheath fluid, medicated core-sheath nanofibers (E3) were fabricated continuously and robustly. The monolithic nanofibers (E2) from a conventional blending electrospinning were prepared as a comparison. FIN existed in an amorphous state within both E2 and E3 nanofibers, attributed to its excellent compatibility with EC. The sustained release profiles of nanofibers E2 and E3 are similar, but the penetration rates of FIN molecules from the nanofibers E2 and E3 always have significant differences from the initial tests at 0.5 h (10.32 ± 4.31% and 12.85 ± 5.14% for nanofibers E2 and E3, respectively) to the final tests at 4.0 h (38.16 ± 5.47% and 51.31 ± 5.19% for nanofibers E2 and E3, respectively). The mechanism underlying the robust preparation enabled by the unspinnable sheath fluid is proposed: it prevents multiple abnormal phenomena inherent to single-fluid blending processes. This protocol offers a versatile strategy to upgrade traditional single-fluid blending electrospinning products, endowing them with an improved functional performance.
SN - 2191-1363
ER -