Biaxial Electrospinning of Poly(lactic acid)/Poly(butylene adipate-co-terephthalate) Blend and Polyvinylpyrrolidone Membranes for Topical Delivery of Betamethasone Valerate
- 1Master Program in Chemistry, State University of West Paraná, 645, Rua da Faculdade, Toledo 85903-000, Paraná, Brazil
- 2Department of Chemistry, State University of Maringá, 5790, Av. Colombo, Maringá 87020-900, Paraná, Brazil
Abstract
Psoriasis is one of the most common skin diseases in the world, and its treatment results in an improvement in the quality of life of patients, carried out mainly with the use of topical corticosteroids such as ointments and gels. As an alternative to conventional treatment of psoriasis, this work presents a study on the production and characterization of polymeric membranes containing betamethasone valerate produced by biaxial electrospinning. PVP has high solubility in water, resulting in rapid release of the incorporated drug. ECOVIO® (BASF, Ludwigshafen, Germany), composed of PLA and PBAT polymers, has good mechanical properties and forms membranes with controlled drug release, due to its hydrophobic characteristics. The produced membranes were characterized by SEM, FTIR, TGA, DSC and XRD. It was demonstrated that the selected polymers presented adequate conditions of electrospinning for membranes prepared in biaxial mode. Characterization showed a possible compatibility between the drug incorporated in the amorphous state and polymers, which also showed increased thermal stability. An increase in the availability of betamethasone valerate incorporated into the membranes (95%) in relation to the isolated active ingredient (20%) was observed in 24 h. Thus, according to the results obtained, the produced membrane is promising for the controlled release of betamethasone valerate.
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BibTeX
@article{schons2026biaxial,
title = {{Biaxial Electrospinning of Poly(lactic acid)/Poly(butylene adipate-co-terephthalate) Blend and Polyvinylpyrrolidone Membranes for Topical Delivery of Betamethasone Valerate}},
author = {Édina Liara Schons and Diogo José Salamanca and Gabriel Nardi Fraga and Douglas Cardoso Dragunski and Josiane Caetano},
journal = {Polymers},
year = {2026},
month = nov,
doi = {10.3390/polym18212725},
url = {https://www.mdpi.com/2073-4360/18/21/2725},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Biaxial Electrospinning of Poly(lactic acid)/Poly(butylene adipate-co-terephthalate) Blend and Polyvinylpyrrolidone Membranes for Topical Delivery of Betamethasone Valerate
AU - Édina Liara Schons
AU - Diogo José Salamanca
AU - Gabriel Nardi Fraga
AU - Douglas Cardoso Dragunski
AU - Josiane Caetano
PY - 2026
DA - 2026/11/02
JO - Polymers
DO - 10.3390/polym18212725
UR - https://www.mdpi.com/2073-4360/18/21/2725
AB - Psoriasis is one of the most common skin diseases in the world, and its treatment results in an improvement in the quality of life of patients, carried out mainly with the use of topical corticosteroids such as ointments and gels. As an alternative to conventional treatment of psoriasis, this work presents a study on the production and characterization of polymeric membranes containing betamethasone valerate produced by biaxial electrospinning. PVP has high solubility in water, resulting in rapid release of the incorporated drug. ECOVIO® (BASF, Ludwigshafen, Germany), composed of PLA and PBAT polymers, has good mechanical properties and forms membranes with controlled drug release, due to its hydrophobic characteristics. The produced membranes were characterized by SEM, FTIR, TGA, DSC and XRD. It was demonstrated that the selected polymers presented adequate conditions of electrospinning for membranes prepared in biaxial mode. Characterization showed a possible compatibility between the drug incorporated in the amorphous state and polymers, which also showed increased thermal stability. An increase in the availability of betamethasone valerate incorporated into the membranes (95%) in relation to the isolated active ingredient (20%) was observed in 24 h. Thus, according to the results obtained, the produced membrane is promising for the controlled release of betamethasone valerate.
SN - 2073-4360
ER -