Effectiveness of hyperbaric oxygenation therapy in post-stroke dysphagia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials
4 affiliations
- 1Heilongjiang University of Chinese Medicine
- 2Rehabilitation Center, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Provincial Key Laboratory of Brain Function and Neurorehabilitation
- 3The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
- 4The First Affiliated Hospital of Heilongjiang University of Chinese Medicine
Abstract
Background To investigate the effectiveness of hyperbaric oxygen in treating Post-Stroke dysphagia using meta-analysis and trial sequential analysis (TSA). Methods A comprehensive search was conducted through 8 databases: Scopus, PubMed, Cochrane, Embase, Web of Science, CNKI, VIP, and Wanfang, until 1 May 2026. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We assessed methodological quality with the Cochrane risk-of-bias tool. Results 14 RCTs involving 1114 participants were included. Results showed: Swallowing function scales (lower scores indicate improvement): Standardized Swallowing Assessment (SSA): SMD = − 0.81, P < 0.00001. Video Fluoroscopic Swallowing Study (VFSS): MD = 1.60, P = 0.0003. Water Swallowing Test (WST): MD = − 1.27, P = 0.0001. Clinical Effective Rate (proportion of patients achieving ≥ 2-point improvement or returning to oral feeding): RR = 1.28, P < 0.0001. Quality of life and intake (higher scores indicate improvement): Swallowing Quality of Life (SWAL–QOL): MD = 1.11, P = 0.04. Functional Oral Intake Scale (FOIS): MD = 1.17, P < 0.0001. National Institutes of Health Stroke Scale (NIHSS): MD = − 5.85, P < 0.00001. Quality assessment Risk of bias was reported by domain. GRADE certainty of evidence ranged from very low to low due to heterogeneity and risk of bias. Conclusions Adjunctive HBO may improve swallowing function and related outcomes in PSD, but the clinical certainty is limited by methodological weaknesses, heterogeneity, incomplete reporting of intervention parameters, and insufficient TSA information size for several patient-centered outcomes.
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BibTeX
@article{lin2026effectiveness,
title = {{Effectiveness of hyperbaric oxygenation therapy in post-stroke dysphagia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials}},
author = {Xiaoguang Lin and Linjing Wang and Minmin Wu and Qiuxin Chen and Bingyao Li and Shuo Niu and Luwen Zhu},
journal = {European Journal of Medical Research},
year = {2026},
month = oct,
doi = {10.1186/s40001-026-04910-y},
url = {https://doi.org/10.1186/s40001-026-04910-y},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effectiveness of hyperbaric oxygenation therapy in post-stroke dysphagia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials
AU - Xiaoguang Lin
AU - Linjing Wang
AU - Minmin Wu
AU - Qiuxin Chen
AU - Bingyao Li
AU - Shuo Niu
AU - Luwen Zhu
PY - 2026
DA - 2026/10/25
JO - European Journal of Medical Research
DO - 10.1186/s40001-026-04910-y
UR - https://doi.org/10.1186/s40001-026-04910-y
AB - Background To investigate the effectiveness of hyperbaric oxygen in treating Post-Stroke dysphagia using meta-analysis and trial sequential analysis (TSA). Methods A comprehensive search was conducted through 8 databases: Scopus, PubMed, Cochrane, Embase, Web of Science, CNKI, VIP, and Wanfang, until 1 May 2026. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We assessed methodological quality with the Cochrane risk-of-bias tool. Results 14 RCTs involving 1114 participants were included. Results showed: Swallowing function scales (lower scores indicate improvement): Standardized Swallowing Assessment (SSA): SMD = − 0.81, P < 0.00001. Video Fluoroscopic Swallowing Study (VFSS): MD = 1.60, P = 0.0003. Water Swallowing Test (WST): MD = − 1.27, P = 0.0001. Clinical Effective Rate (proportion of patients achieving ≥ 2-point improvement or returning to oral feeding): RR = 1.28, P < 0.0001. Quality of life and intake (higher scores indicate improvement): Swallowing Quality of Life (SWAL–QOL): MD = 1.11, P = 0.04. Functional Oral Intake Scale (FOIS): MD = 1.17, P < 0.0001. National Institutes of Health Stroke Scale (NIHSS): MD = − 5.85, P < 0.00001. Quality assessment Risk of bias was reported by domain. GRADE certainty of evidence ranged from very low to low due to heterogeneity and risk of bias. Conclusions Adjunctive HBO may improve swallowing function and related outcomes in PSD, but the clinical certainty is limited by methodological weaknesses, heterogeneity, incomplete reporting of intervention parameters, and insufficient TSA information size for several patient-centered outcomes.
SN - 2047-783X
ER -