A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (the DIGICHOL randomised controlled trial)
- 1GAIA AG
Abstract
Structured lifestyle modification is the guideline-mandated foundation of lipid management but is rarely delivered in routine care. We evaluated lipodia, a fully self-guided digital health application providing structured lifestyle support, in a pragmatic randomised controlled trial conducted online. Adults with LDL-cholesterol above their risk-adapted target (n = 278) were randomised 1:1 to usual care plus lipodia or usual care alone. After six months, lipodia significantly reduced LDL-cholesterol relative to usual care (adjusted between-group difference in relative change -3.9%; p = 0.029), with nearly twice as many users achieving a clinically meaningful reduction of at least 10% (41.7% versus 23.8%; p = 0.002). lipodia also significantly improved patient activation, non-HDL-cholesterol, and health-related quality of life, with high uptake, low attrition, and no adverse device effects. As a self-guided tool, lipodia provides a scalable and guideline-concordant means of delivering structured lifestyle support that is rarely available in routine care.
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BibTeX
@misc{riepenhausen2026selfguided,
title = {{A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (the DIGICHOL randomised controlled trial)}},
author = {A. Riepenhausen and C. Ekerdt and B. Meyer and K. Jauch-Chara},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.15.26363103},
url = {https://www.medrxiv.org/content/10.64898/2026.09.15.26363103v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (the DIGICHOL randomised controlled trial)
AU - A. Riepenhausen
AU - C. Ekerdt
AU - B. Meyer
AU - K. Jauch-Chara
PY - 2026
DA - 2026/09/15
PB - medRxiv
DO - 10.64898/2026.09.15.26363103
UR - https://www.medrxiv.org/content/10.64898/2026.09.15.26363103v1
AB - Structured lifestyle modification is the guideline-mandated foundation of lipid management but is rarely delivered in routine care. We evaluated lipodia, a fully self-guided digital health application providing structured lifestyle support, in a pragmatic randomised controlled trial conducted online. Adults with LDL-cholesterol above their risk-adapted target (n = 278) were randomised 1:1 to usual care plus lipodia or usual care alone. After six months, lipodia significantly reduced LDL-cholesterol relative to usual care (adjusted between-group difference in relative change -3.9%; p = 0.029), with nearly twice as many users achieving a clinically meaningful reduction of at least 10% (41.7% versus 23.8%; p = 0.002). lipodia also significantly improved patient activation, non-HDL-cholesterol, and health-related quality of life, with high uptake, low attrition, and no adverse device effects. As a self-guided tool, lipodia provides a scalable and guideline-concordant means of delivering structured lifestyle support that is rarely available in routine care.
ER -