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Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Longitudinal Voice Outcomes After Atelocollagen Injection Laryngoplasty for Vocal Fold Paralysis and Vocal Fold Atrophy/Sulcus

  • Kiyohito Hosokawa1,2,3
  • Masayuki Nozawa1
  • Takanari Kawabe1
  • Akihiro Nagata1
  • Itsuki Kitayama1,2
  • Kenji Aruga1,3
  • Maki Yamashita1,2
  • Takeshi Tsuda1
  • Yoshiyuki Ozono1
  • Hidenori Tanaka1
  • Yohei Maeda1,2
  • Takahito Fukusumi1,3
2 more authors
  • Makoto Ogawa1,2
  • Hidenori Inohara1
  1. 1Department of Otorhinolaryngology–Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Suita 565-0871, Osaka, Japan
  2. 2Department of Otorhinolaryngology, Japan Community Health Care Organization Osaka Hospital, Osaka 553-0003, Japan
  3. 3Department of Otorhinolaryngology–Head and Neck Surgery, Osaka International Medical & Science Center, Osaka 543-0042, Japan
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Abstract

Background: Atelocollagen injection laryngoplasty is a minimally invasive treatment for glottic insufficiency, but the durability of its effects and whether longitudinal responses differ according to the underlying disorder remain unclear. Methods: We retrospectively analyzed prospectively collected clinical data from three institutions. The cohort comprised 92 patients and 142 injection episodes, including 75 patients with vocal fold paralysis and 17 with vocal fold atrophy/sulcus. Acoustic Voice Quality Index (AVQI), maximum phonation time (MPT), and Voice Handicap Index-10 (VHI-10) were evaluated from baseline through 1 year. Longitudinal changes were analyzed using mixed-effects models, and clinically meaningful response was assessed using prespecified criteria. Extended follow-up at 1.5 years and ≥2 years was evaluated in the subset of patients with vocal fold paralysis with available long-term data. Results: In vocal fold paralysis, AVQI, MPT, and VHI-10 improved significantly at all follow-up time points through 1 year. In vocal fold atrophy/sulcus, AVQI and VHI-10 showed significant improvement mainly at 1 and 3 months, whereas MPT did not show consistent improvement. The time-by-disease-group interaction was significant for AVQI (p = 0.006), but not for MPT (p = 0.239) or VHI-10 (p = 0.559). AVQI responder trajectories also differed between disease groups (p = 0.023). In the available long-term subset (n = 19 at each time point), all three outcomes remained significantly improved at 1.5 years and ≥2 years. At ≥2 years, responder rates were 41.9% for AVQI and 48.4% for VHI-10, and MPT functional recovery was 31.6%. Conclusions: Atelocollagen injection laryngoplasty was associated with sustained voice improvement through 1 year in vocal fold paralysis, with improvement also observed at ≥2 years in a selected subset. Effects in vocal fold atrophy/sulcus were less consistently sustained.

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Cite

BibTeXRIS
BibTeX
@article{hosokawa2026longitudinal,
  title = {{Longitudinal Voice Outcomes After Atelocollagen Injection Laryngoplasty for Vocal Fold Paralysis and Vocal Fold Atrophy/Sulcus}},
  author = {Kiyohito Hosokawa and Masayuki Nozawa and Takanari Kawabe and Akihiro Nagata and Itsuki Kitayama and Kenji Aruga and Maki Yamashita and Takeshi Tsuda and Yoshiyuki Ozono and Hidenori Tanaka and Yohei Maeda and Takahito Fukusumi and Makoto Ogawa and Hidenori Inohara},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = oct,
  doi = {10.3390/jcm15207772},
  url = {https://www.mdpi.com/2077-0383/15/20/7772},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Longitudinal Voice Outcomes After Atelocollagen Injection Laryngoplasty for Vocal Fold Paralysis and Vocal Fold Atrophy/Sulcus
AU  - Kiyohito Hosokawa
AU  - Masayuki Nozawa
AU  - Takanari Kawabe
AU  - Akihiro Nagata
AU  - Itsuki Kitayama
AU  - Kenji Aruga
AU  - Maki Yamashita
AU  - Takeshi Tsuda
AU  - Yoshiyuki Ozono
AU  - Hidenori Tanaka
AU  - Yohei Maeda
AU  - Takahito Fukusumi
AU  - Makoto Ogawa
AU  - Hidenori Inohara
PY  - 2026
DA  - 2026/10/01
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15207772
UR  - https://www.mdpi.com/2077-0383/15/20/7772
AB  - Background: Atelocollagen injection laryngoplasty is a minimally invasive treatment for glottic insufficiency, but the durability of its effects and whether longitudinal responses differ according to the underlying disorder remain unclear. Methods: We retrospectively analyzed prospectively collected clinical data from three institutions. The cohort comprised 92 patients and 142 injection episodes, including 75 patients with vocal fold paralysis and 17 with vocal fold atrophy/sulcus. Acoustic Voice Quality Index (AVQI), maximum phonation time (MPT), and Voice Handicap Index-10 (VHI-10) were evaluated from baseline through 1 year. Longitudinal changes were analyzed using mixed-effects models, and clinically meaningful response was assessed using prespecified criteria. Extended follow-up at 1.5 years and ≥2 years was evaluated in the subset of patients with vocal fold paralysis with available long-term data. Results: In vocal fold paralysis, AVQI, MPT, and VHI-10 improved significantly at all follow-up time points through 1 year. In vocal fold atrophy/sulcus, AVQI and VHI-10 showed significant improvement mainly at 1 and 3 months, whereas MPT did not show consistent improvement. The time-by-disease-group interaction was significant for AVQI (p = 0.006), but not for MPT (p = 0.239) or VHI-10 (p = 0.559). AVQI responder trajectories also differed between disease groups (p = 0.023). In the available long-term subset (n = 19 at each time point), all three outcomes remained significantly improved at 1.5 years and ≥2 years. At ≥2 years, responder rates were 41.9% for AVQI and 48.4% for VHI-10, and MPT functional recovery was 31.6%. Conclusions: Atelocollagen injection laryngoplasty was associated with sustained voice improvement through 1 year in vocal fold paralysis, with improvement also observed at ≥2 years in a selected subset. Effects in vocal fold atrophy/sulcus were less consistently sustained.
SN  - 2077-0383
ER  -