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PreprintCC BYChemRxiv

Visible-light-Enabled O-Selective Radical Etherification of 1,2-Dicarbonyl Compounds for the Synthesis of Sterically Congested Ethers

  • Shengkun Guo1
  • Sita Claesen1
  • Erik V. Van der Eycken1,2
  • Upendra K. Sharma3,4
4 affiliations
  1. 1Department of Chemistry, University of Leuven (KU Leuven, Celestijnenlaan 200F, Leuven, Belgium, B-3001
  2. 2Peoples’ Friendship University of Russia (RUDN University, Miklukho-Maklaya street 6, Moscow, Russia, 117198
  3. 3Department of Chemistry and Biochemistry
  4. 4University of Missouri - St. Louis
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Abstract

A visible-light-promoted, triphenylphosphine-mediated protocol for the direct O-selective etherification of 1,2-diketones is reported. Using NHPI esters as radical precursors, this method provides an efficient route to sterically congested ethers under mild conditions. The strategy exhibits compatibility with various tertiary alkyl radicals and 1,2-diketone derivatives. Mechanistic studies support a radical-mediated pathway, and adaptation to a photochemical continuous-flow platform enables improved efficiency, scalability, and operational control.

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Cite

BibTeXRIS
BibTeX
@misc{guo2026visiblelightenabled,
  title = {{Visible-light-Enabled O-Selective Radical Etherification of 1,2-Dicarbonyl Compounds for the Synthesis of Sterically Congested Ethers}},
  author = {Shengkun Guo and Sita Claesen and Erik V. Van der Eycken and Upendra K. Sharma},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15006666/v2},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15006666/v2},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Visible-light-Enabled O-Selective Radical Etherification of 1,2-Dicarbonyl Compounds for the Synthesis of Sterically Congested Ethers
AU  - Shengkun Guo
AU  - Sita Claesen
AU  - Erik V. Van der Eycken
AU  - Upendra K. Sharma
PY  - 2026
DA  - 2026/10/14
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15006666/v2
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15006666/v2
AB  - A visible-light-promoted, triphenylphosphine-mediated protocol for the direct O-selective etherification of 1,2-diketones is reported. Using NHPI esters as radical precursors, this method provides an efficient route to sterically congested ethers under mild conditions. The strategy exhibits compatibility with various tertiary alkyl radicals and 1,2-diketone derivatives. Mechanistic studies support a radical-mediated pathway, and adaptation to a photochemical continuous-flow platform enables improved efficiency, scalability, and operational control.
ER  -