Gut Microbiota Modulation via Synbiotics: A Perspective for Boosting Antitumor Immunity and Inactivating Carcinogens in Early Life
4 affiliations
- 1Department of Biomedicine and Biochemistry, Universitas Muhammadiyah Surabaya, Surabaya, Indonesia.
- 2Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Brawijaya, Saiful Anwar General Hospital, Malang, Indonesia.
- 3Department of Medicine, Faculty of Medicine, University YARSI, DKI Jakarta, Indonesia.
- 4Department of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Abstract
Objective:: Children are highly susceptible to infections and long-term health risks due to their immature immune systems, which typically develop fully around the age of 12. While early infections generate T and B memory cells, establishing a robust immune foundation is crucial not only for combating pathogens but also for preventing carcinogenesis in later life. Synbiotics, a synergistic combination of probiotics and prebiotics, offer a promising strategy to modulate the gastrointestinal microenvironment.
Method:: This article proposes that synbiotic supplementation provides dual benefits: enhancing immediate immunity and offering potential chemopreventive effects.
Result:: Mechanistically, synbiotics maintain microbial balance (increasing Lactobacillus and Bifidobacterium), which leads to (1) increased production of artificial endogenous immunoglobulins like IgG to neutralize toxins and pathogens; (2) inactivation of cancer-causing chemicals and reduction of unwanted metabolite concentrations; and (3) enhancement of Natural Killer (NK) cell activity and antioxidant capacity, which are vital for tumor surveillance and reducing oxidative stress. By modulating the gut microbiota, synbiotics not only boost IgG levels to prevent common infections but also strengthen the body’s defense against mutagenic agents.
Conclusion:: This opinion article summarizes clinical and preclinical findings to highlight the efficacy of synbiotics as a comprehensive immune booster and a potential agent for early cancer prevention strategies.
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BibTeX
@article{lutfiana2026microbiota,
title = {{Gut Microbiota Modulation via Synbiotics: A Perspective for Boosting Antitumor Immunity and Inactivating Carcinogens in Early Life}},
author = {Nurul Cholifah Lutfiana and Adilla Shafryantyo Purnomo and Azzahra Syadza Nasywantya Purnomo and Athaya Febriantyo Purnomo},
journal = {Asian Pacific Journal of Cancer Prevention : APJCP},
year = {2026},
month = jun,
doi = {10.31557/apjcp.2026.27.6.2315},
url = {https://doi.org/10.31557/apjcp.2026.27.6.2315},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Gut Microbiota Modulation via Synbiotics: A Perspective for Boosting Antitumor Immunity and Inactivating Carcinogens in Early Life
AU - Nurul Cholifah Lutfiana
AU - Adilla Shafryantyo Purnomo
AU - Azzahra Syadza Nasywantya Purnomo
AU - Athaya Febriantyo Purnomo
PY - 2026
DA - 2026/06/22
JO - Asian Pacific Journal of Cancer Prevention : APJCP
DO - 10.31557/apjcp.2026.27.6.2315
UR - https://doi.org/10.31557/apjcp.2026.27.6.2315
AB - Objective:: Children are highly susceptible to infections and long-term health risks due to their immature immune systems, which typically develop fully around the age of 12. While early infections generate T and B memory cells, establishing a robust immune foundation is crucial not only for combating pathogens but also for preventing carcinogenesis in later life. Synbiotics, a synergistic combination of probiotics and prebiotics, offer a promising strategy to modulate the gastrointestinal microenvironment. Method:: This article proposes that synbiotic supplementation provides dual benefits: enhancing immediate immunity and offering potential chemopreventive effects. Result:: Mechanistically, synbiotics maintain microbial balance (increasing Lactobacillus and Bifidobacterium), which leads to (1) increased production of artificial endogenous immunoglobulins like IgG to neutralize toxins and pathogens; (2) inactivation of cancer-causing chemicals and reduction of unwanted metabolite concentrations; and (3) enhancement of Natural Killer (NK) cell activity and antioxidant capacity, which are vital for tumor surveillance and reducing oxidative stress. By modulating the gut microbiota, synbiotics not only boost IgG levels to prevent common infections but also strengthen the body’s defense against mutagenic agents. Conclusion:: This opinion article summarizes clinical and preclinical findings to highlight the efficacy of synbiotics as a comprehensive immune booster and a potential agent for early cancer prevention strategies.
SN - 1513-7368
SN - 2476-762X
ER -