Dosimetric impact of target volume anatomical parameters on radiotherapy after right-sided breast-conserving surgery
- 1Department of Oncology, The People’s Hospital of Rongchang District
- 2Department of Pediatrics, Chongqing University Three Gorges Hospital
Abstract
Objective: To investigate the dosimetric effects of target volume Anatomical Parameters on organ at risk (OAR) following breast-conserving surgery and subsequent radiotherapy in patients with right-sided breast cancer.
Methods: A retrospective study was conducted on 33 patients who underwent post-breast-conserving surgery radiotherapy. The transverse diameter (TD), oblique diameter (OD), and the ratio of transverse diameter to oblique diameter (TOR) were measured at the nipple-center plane for all patients. Bivariate Pearson correlation analysis was used to examine the effects of TD, OD, and TOR on V 20Gy , V 5Gy , D mean of the affected lung; D mean and V 5Gy of heart; D mean of the right coronary artery (RCA); D mean of the left anterior descending artery (LAD); V 5Gy of the contralateral lung; and D mean of the contralateral breast.
Results: OD and TD showed significant correlations with V 20Gy , V 5Gy , and D mean of the affected lung ( 0.5 < R < 0.7, P < 0.01 ); The TD was significantly correlated with Heart_D mean ( R = 0.58, P < 0.01 ), strongly correlated with RCA_D mean ( R = 0.45, P < 0.01 ), and strongly correlated with LAD_D mean ( R = 0.42, P < 0.05 ); The TOR was significantly correlated with Heart_D mean ( R = 0.47, P < 0.01 ), strongly correlated with LAD_D mean ( R = 0.47, P < 0.01 ).
Conclusion: Exploratory observational thresholds from our cohort: target volume with TD >8.00 cm or OD >19.56 cm indicates higher lung dose risk; TD >8.00 cm or TOR >0.47 indicates higher cardiac dose risk. These thresholds were not optimized by ROC analysis and cannot be directly used for clinical risk stratification; prospective validation is needed. Clinical planning should minimize heart and lung radiation.
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BibTeX
@article{zou2026dosimetric,
title = {{Dosimetric impact of target volume anatomical parameters on radiotherapy after right-sided breast-conserving surgery}},
author = {Lu Zou and Zeping Deng and Xingliang Liao and Ling Duan and Xuefen Liu},
journal = {Frontiers in Oncology},
year = {2026},
month = oct,
doi = {10.3389/fonc.2026.1944304},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1944304/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Dosimetric impact of target volume anatomical parameters on radiotherapy after right-sided breast-conserving surgery
AU - Lu Zou
AU - Zeping Deng
AU - Xingliang Liao
AU - Ling Duan
AU - Xuefen Liu
PY - 2026
DA - 2026/10/26
JO - Frontiers in Oncology
DO - 10.3389/fonc.2026.1944304
UR - https://www.frontiersin.org/articles/10.3389/fonc.2026.1944304/full
AB - Objective: To investigate the dosimetric effects of target volume Anatomical Parameters on organ at risk (OAR) following breast-conserving surgery and subsequent radiotherapy in patients with right-sided breast cancer. Methods: A retrospective study was conducted on 33 patients who underwent post-breast-conserving surgery radiotherapy. The transverse diameter (TD), oblique diameter (OD), and the ratio of transverse diameter to oblique diameter (TOR) were measured at the nipple-center plane for all patients. Bivariate Pearson correlation analysis was used to examine the effects of TD, OD, and TOR on V 20Gy , V 5Gy , D mean of the affected lung; D mean and V 5Gy of heart; D mean of the right coronary artery (RCA); D mean of the left anterior descending artery (LAD); V 5Gy of the contralateral lung; and D mean of the contralateral breast. Results: OD and TD showed significant correlations with V 20Gy , V 5Gy , and D mean of the affected lung ( 0.5 < R < 0.7, P < 0.01 ); The TD was significantly correlated with Heart_D mean ( R = 0.58, P < 0.01 ), strongly correlated with RCA_D mean ( R = 0.45, P < 0.01 ), and strongly correlated with LAD_D mean ( R = 0.42, P < 0.05 ); The TOR was significantly correlated with Heart_D mean ( R = 0.47, P < 0.01 ), strongly correlated with LAD_D mean ( R = 0.47, P < 0.01 ). Conclusion: Exploratory observational thresholds from our cohort: target volume with TD >8.00 cm or OD >19.56 cm indicates higher lung dose risk; TD >8.00 cm or TOR >0.47 indicates higher cardiac dose risk. These thresholds were not optimized by ROC analysis and cannot be directly used for clinical risk stratification; prospective validation is needed. Clinical planning should minimize heart and lung radiation.
SN - 2234-943X
ER -