Dosimetric Comparison of Intensity-Modulated Radiotherapy and Four-Field Three-Dimensional Conformal Radiotherapy in the Management of Prostate Cancer: A Retrospective Dual-Centre Analysis
4 affiliations
- 1Oncology department Minya university
- 2department of clinical oncology
- 3Department of oncology, El-Minia faculty of medicine
- 4Clinical Oncology and Nuclear Medicine - Faculty of Medicine -Minia University, Egypt.
Abstract
Background
Radiotherapy is a cornerstone in the management of localized and locally advanced prostate cancer. Three-dimensional conformal radiotherapy (3D-CRT) has been widely used, while intensity-modulated radiotherapy (IMRT) allows more conformal dose distribution and potentially better sparing of surrounding normal tissues. This retrospective study aimed to compare the dosimetric characteristics of IMRT and four-field 3D-CRT in patients with prostate cancer.
Methods
This retrospective study included 63 patients with prostate cancer treated at Minya university and Ahmed Maher Teaching Hospital. Patients were divided into two treatment groups: 30 patients treated using four-field 3D-CRT and 33 patients treated using IMRT. All patients received a total prescribed dose of 70 Gy in 35 fractions. Treatment planning was performed using an Elekta radiotherapy system. Depending on clinical stage, treatment volumes included the prostate alone or the prostate with pelvic lymphatic regions. Dosimetric parameters for the target volume and organs at risk were evaluated and compared between the two techniques.
Results
The dosimetric analysis demonstrated differences between IMRT and four-field 3D-CRT in target coverage and dose distribution, as well as in the radiation exposure of surrounding organs at risk. IMRT provided a more conformal dose distribution around the intended treatment volume while allowing improved dose optimization to adjacent normal tissues.
Conclusion
In this retrospective cohort, IMRT demonstrated dosimetric advantages compared with four-field 3D-CRT for prostate cancer radiotherapy. These findings support the use of IMRT when available to achieve improved treatment-plan conformity and normal-tissue sparing while maintaining adequate target coverage.
Related
- Dosimetric and Treatment Delivery Efficiency Comparison of Two Ring-gantry Linear Accelerator Platforms for Liver Stereotactic Body Radiotherapy
- Dosimetric Comparison of Contemporary Stereotactic Radiotherapy Platforms for Brain Metastases: Towards Personalized Technology Selection
- Dosimetric feasibility of lattice radiotherapy for bulky tumors: a paired VMAT vs. helical tomotherapy comparison - the STRYKE trial
- Updated dosimetric comparison of HDR interventional radiotherapy including ⁶⁰Co sources versus VMAT and electron beam therapy for NMSC.
- Comprehensive motion management for liver SBRT on a 1.5 T MR-Linac: Initial clinical experience and dosimetric comparison with an ITV-based workflow
BibTeX
@article{abdallah2026dosimetric,
title = {{Dosimetric Comparison of Intensity-Modulated Radiotherapy and Four-Field Three-Dimensional Conformal Radiotherapy in the Management of Prostate Cancer: A Retrospective Dual-Centre Analysis}},
author = {Alaa AbdAllah and wafaa mohamed and Amani Saber and Nada Sholkamy},
journal = {Minia Journal of Medical Research},
year = {2026},
month = oct,
doi = {10.21608/mjmr.2026.533694.2395},
url = {https://doi.org/10.21608/mjmr.2026.533694.2395},
note = {CC BY},
}
RIS
TY - JOUR
TI - Dosimetric Comparison of Intensity-Modulated Radiotherapy and Four-Field Three-Dimensional Conformal Radiotherapy in the Management of Prostate Cancer: A Retrospective Dual-Centre Analysis
AU - Alaa AbdAllah
AU - wafaa mohamed
AU - Amani Saber
AU - Nada Sholkamy
PY - 2026
DA - 2026/10/25
JO - Minia Journal of Medical Research
DO - 10.21608/mjmr.2026.533694.2395
UR - https://doi.org/10.21608/mjmr.2026.533694.2395
AB - Background Radiotherapy is a cornerstone in the management of localized and locally advanced prostate cancer. Three-dimensional conformal radiotherapy (3D-CRT) has been widely used, while intensity-modulated radiotherapy (IMRT) allows more conformal dose distribution and potentially better sparing of surrounding normal tissues. This retrospective study aimed to compare the dosimetric characteristics of IMRT and four-field 3D-CRT in patients with prostate cancer. Methods This retrospective study included 63 patients with prostate cancer treated at Minya university and Ahmed Maher Teaching Hospital. Patients were divided into two treatment groups: 30 patients treated using four-field 3D-CRT and 33 patients treated using IMRT. All patients received a total prescribed dose of 70 Gy in 35 fractions. Treatment planning was performed using an Elekta radiotherapy system. Depending on clinical stage, treatment volumes included the prostate alone or the prostate with pelvic lymphatic regions. Dosimetric parameters for the target volume and organs at risk were evaluated and compared between the two techniques. Results The dosimetric analysis demonstrated differences between IMRT and four-field 3D-CRT in target coverage and dose distribution, as well as in the radiation exposure of surrounding organs at risk. IMRT provided a more conformal dose distribution around the intended treatment volume while allowing improved dose optimization to adjacent normal tissues. Conclusion In this retrospective cohort, IMRT demonstrated dosimetric advantages compared with four-field 3D-CRT for prostate cancer radiotherapy. These findings support the use of IMRT when available to achieve improved treatment-plan conformity and normal-tissue sparing while maintaining adequate target coverage.
SN - 2682-4558
ER -