Comparative study between dexmedetomidine, magnesium sulfate, and lidocaine on the pressor response to laryngoscopic intubation and optic nerve sheath diameter measurement in laparoscopic gynecological surgery.
- 1Department of Anesthesia, Intensive Care Unit and Pain Management, Faculty of Medicine, Assiut University, Assiut, Egypt.
- 2Department of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, New Vally University, New Valley Governorate, Egypt.
Abstract
Background
The use of laryngoscope and intubation in general anesthesia can cause stress response like hypertension and tachycardia. Intravenous (IV) dexmedetomidine, magnesium sulfate (MgSO4), and lidocaine have been used to compare their effect on pressor response, hemodynamics, and optic nerve sheath diameter (ONSD).Methods
One hundred and two female patients slated for elective gynecologic laparoscopic surgery under general anesthesia were involved in this randomized, double-blinded study. They were randomized to receive IV dexmedetomidine (Group D, n = 34), IV magnesium SO4 (Group M, n = 34), or IV lidocaine (Group L, n = 34). Heart rate (HR) and mean arterial pressure were assessed prior to and following medication usage, prior to and following the induction of anesthesia, following intubation (cuff inflation (1 minute), and 5 and 10 minutes following intubation. At the same timeframe, the ONSD measurement was conducted.Results
After intubation for 1 min (cuff inflation), Group D had the lowest HR compared to groups M and L and also Mean blood pressure (MBP) was lower in group D and group M than group L. At 5 min and 10 min after intubation, HR was lower in group D than group M and group L and MBP was lowest in group D than group M and group L. ONSD was lower in group D than group M and group L at 1, 5, and 10 min after intubation.Conclusions
IV dexmedetomidine offers the best control on hemodynamics and ONSD responses during laryngoscopic intubation than IV MgSO4 and lidocaine.
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BibTeX
@article{mansour2026comparative,
title = {{Comparative study between dexmedetomidine, magnesium sulfate, and lidocaine on the pressor response to laryngoscopic intubation and optic nerve sheath diameter measurement in laparoscopic gynecological surgery.}},
author = {Sara M Mansour and Ahmed I Abd El Sabour and Hamdy Abbas and Armia Magdi and Yara H Abbas},
journal = {Saudi journal of anaesthesia},
year = {2026},
month = oct,
doi = {10.4103/sja.sja_356_26},
url = {https://europepmc.org/article/MED/42960331},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Comparative study between dexmedetomidine, magnesium sulfate, and lidocaine on the pressor response to laryngoscopic intubation and optic nerve sheath diameter measurement in laparoscopic gynecological surgery.
AU - Sara M Mansour
AU - Ahmed I Abd El Sabour
AU - Hamdy Abbas
AU - Armia Magdi
AU - Yara H Abbas
PY - 2026
DA - 2026/10/01
JO - Saudi journal of anaesthesia
DO - 10.4103/sja.sja_356_26
UR - https://europepmc.org/article/MED/42960331
AB - Background The use of laryngoscope and intubation in general anesthesia can cause stress response like hypertension and tachycardia. Intravenous (IV) dexmedetomidine, magnesium sulfate (MgSO4), and lidocaine have been used to compare their effect on pressor response, hemodynamics, and optic nerve sheath diameter (ONSD).Methods One hundred and two female patients slated for elective gynecologic laparoscopic surgery under general anesthesia were involved in this randomized, double-blinded study. They were randomized to receive IV dexmedetomidine (Group D, n = 34), IV magnesium SO4 (Group M, n = 34), or IV lidocaine (Group L, n = 34). Heart rate (HR) and mean arterial pressure were assessed prior to and following medication usage, prior to and following the induction of anesthesia, following intubation (cuff inflation (1 minute), and 5 and 10 minutes following intubation. At the same timeframe, the ONSD measurement was conducted.Results After intubation for 1 min (cuff inflation), Group D had the lowest HR compared to groups M and L and also Mean blood pressure (MBP) was lower in group D and group M than group L. At 5 min and 10 min after intubation, HR was lower in group D than group M and group L and MBP was lowest in group D than group M and group L. ONSD was lower in group D than group M and group L at 1, 5, and 10 min after intubation.Conclusions IV dexmedetomidine offers the best control on hemodynamics and ONSD responses during laryngoscopic intubation than IV MgSO4 and lidocaine.
SN - 1658-354X
SN - 0975-3125
ER -