ROS-Scavenging Selenium Nanoparticle Hydrogel Synergizes with Adipose-Derived Stem Cells to Promote Peripheral Nerve Repair
- 1The Third Hospital of Hebei Medical University , , No. 139 Ziqiang Road , ,
- 2Handan First Hospital , , No. 25 Congtai Road , ,
Abstract
Peripheral nerve injury (PNI) remains challenging due to oxidative stress and inflammation limiting stem cell therapy. Here, we developed an injectable, ROS-scavenging selenium nanoparticle (SeNP) hydrogel (SeNP-Gel) to protect adipose-derived stem cells (ADSCs) and enhance peripheral nerve repair. SeNP-Gel exhibited excellent biocompatibility, a porous structure, and favorable mechanical properties, effectively scavenging hydrogen peroxide and reducing oxidative stress to improve ADSC survival. In vitro, the hydrogel promoted Schwann cell migration, angiogenesis, and M2 microglial polarization, thereby alleviating neuroinflammation. In a rat sciatic nerve injury model, the ADSCs/SeNP-Gel composite synergistically accelerated axonal regeneration, myelination, and functional recovery, outperforming either component alone. This strategy integrates SeNPs, hydrogel, and ADSCs to coordinate oxidative stress modulation and immune microenvironment remodeling for PNI treatment.
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BibTeX
@article{xie2026rosscavenging,
title = {{ROS-Scavenging Selenium Nanoparticle Hydrogel Synergizes with Adipose-Derived Stem Cells to Promote Peripheral Nerve Repair}},
author = {Meng Xie and Jiang Jiang and Fengyu Wang and Li Wang and Zheng Cheng and Li Lv and Xinzhong Shao},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c05916},
url = {https://pubs.acs.org/acsodf/article/11/41/63084/5447186/ROS-Scavenging-Selenium-Nanoparticle-Hydrogel},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - ROS-Scavenging Selenium Nanoparticle Hydrogel Synergizes with Adipose-Derived Stem Cells to Promote Peripheral Nerve Repair
AU - Meng Xie
AU - Jiang Jiang
AU - Fengyu Wang
AU - Li Wang
AU - Zheng Cheng
AU - Li Lv
AU - Xinzhong Shao
PY - 2026
DA - 2026/10/08
JO - ACS Omega
DO - 10.1021/acsomega.6c05916
UR - https://pubs.acs.org/acsodf/article/11/41/63084/5447186/ROS-Scavenging-Selenium-Nanoparticle-Hydrogel
AB - Peripheral nerve injury (PNI) remains challenging due to oxidative stress and inflammation limiting stem cell therapy. Here, we developed an injectable, ROS-scavenging selenium nanoparticle (SeNP) hydrogel (SeNP-Gel) to protect adipose-derived stem cells (ADSCs) and enhance peripheral nerve repair. SeNP-Gel exhibited excellent biocompatibility, a porous structure, and favorable mechanical properties, effectively scavenging hydrogen peroxide and reducing oxidative stress to improve ADSC survival. In vitro, the hydrogel promoted Schwann cell migration, angiogenesis, and M2 microglial polarization, thereby alleviating neuroinflammation. In a rat sciatic nerve injury model, the ADSCs/SeNP-Gel composite synergistically accelerated axonal regeneration, myelination, and functional recovery, outperforming either component alone. This strategy integrates SeNPs, hydrogel, and ADSCs to coordinate oxidative stress modulation and immune microenvironment remodeling for PNI treatment.
SN - 2470-1343
ER -