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Peer-reviewedLicence not statedNature

Programmable design of functional proteins from natural language

  • Fengyuan Dai1,2
  • Shiyang You3
  • Yudian Zhu1
  • Yuan Gao4
  • Lihao Fu4
  • Xibin Zhou1
  • Jin Su1
  • Chentong Wang5
  • Yuliang Fan1
  • Qingsong Tan1
  • Xiaoxiao Ma3
  • Xianjun Deng3
21 more authors
  • Letong Yu3
  • Hui Qian1
  • Yan He5
  • Yitao Ke5
  • Zhe Zhang1
  • Chenchen Han1
  • Xing Chang5
  • Liangzhen Zheng6
  • Sheng Wang7,6
  • Yuan Ji8
  • Kexin Hao8
  • Longxing Cao5
  • Yajie Wang1
  • An‐Ping Zeng1,9
  • Shunzhi Wang7,6
  • Chunjun Zhan1
  • Jing Zhao8
  • Tong Si10
  • Jianming Liu11,12
  • Hongyuan Lu13
  • Fajie Yuan14,15
15 affiliations
  1. 1School of Engineering, Westlake University, Hangzhou, China
  2. 2Zhejiang University, Hangzhou, China
  3. 3Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China
  4. 4State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
  5. 5School of Life Sciences, Westlake University, Hangzhou, China
  6. 6Shanghai Zelixir Biotech, Shanghai, China
  7. 7Department of Biochemistry, University of Washington, Seattle, WA, USA
  8. 8State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, China
  9. 9Zhejiang Key Laboratory of Low-Carbon Intelligent Synthetic Biology, School of Engineering, Westlake University, Hangzhou, China
  10. 10State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. [email protected]
  11. 11School of Engineering, Westlake University, Hangzhou, China. [email protected]
  12. 12Zhejiang Key Laboratory of Low-Carbon Intelligent Synthetic Biology, School of Engineering, Westlake University, Hangzhou, China. [email protected]
  13. 13Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China. [email protected]
  14. 14School of Engineering, Westlake University, Hangzhou, China. [email protected]
  15. 15Zhejiang Key Laboratory of Low-Carbon Intelligent Synthetic Biology, School of Engineering, Westlake University, Hangzhou, China. [email protected]
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Cite

BibTeXRIS
BibTeX
@article{dai2026programmable,
  title = {{Programmable design of functional proteins from natural language}},
  author = {Fengyuan Dai and Shiyang You and Yudian Zhu and Yuan Gao and Lihao Fu and Xibin Zhou and Jin Su and Chentong Wang and Yuliang Fan and Qingsong Tan and Xiaoxiao Ma and Xianjun Deng and Letong Yu and Hui Qian and Yan He and Yitao Ke and Zhe Zhang and Chenchen Han and Xing Chang and Liangzhen Zheng and Sheng Wang and Yuan Ji and Kexin Hao and Longxing Cao and Yajie Wang and An‐Ping Zeng and Shunzhi Wang and Chunjun Zhan and Jing Zhao and Tong Si and Jianming Liu and Hongyuan Lu and Fajie Yuan},
  journal = {Nature},
  year = {2026},
  month = oct,
  doi = {10.1038/s41586-026-11205-z},
  url = {https://doi.org/10.1101/2024.08.01.606258},
}
RIS
TY  - JOUR
TI  - Programmable design of functional proteins from natural language
AU  - Fengyuan Dai
AU  - Shiyang You
AU  - Yudian Zhu
AU  - Yuan Gao
AU  - Lihao Fu
AU  - Xibin Zhou
AU  - Jin Su
AU  - Chentong Wang
AU  - Yuliang Fan
AU  - Qingsong Tan
AU  - Xiaoxiao Ma
AU  - Xianjun Deng
AU  - Letong Yu
AU  - Hui Qian
AU  - Yan He
AU  - Yitao Ke
AU  - Zhe Zhang
AU  - Chenchen Han
AU  - Xing Chang
AU  - Liangzhen Zheng
AU  - Sheng Wang
AU  - Yuan Ji
AU  - Kexin Hao
AU  - Longxing Cao
AU  - Yajie Wang
AU  - An‐Ping Zeng
AU  - Shunzhi Wang
AU  - Chunjun Zhan
AU  - Jing Zhao
AU  - Tong Si
AU  - Jianming Liu
AU  - Hongyuan Lu
AU  - Fajie Yuan
PY  - 2026
DA  - 2026/10/21
JO  - Nature
DO  - 10.1038/s41586-026-11205-z
UR  - https://doi.org/10.1101/2024.08.01.606258
SN  - 0028-0836
SN  - 1476-4687
ER  -