Predictors of physical performance decline in patients receiving maintenance hemodialysis: a prospective observational study

@article{madeira2026predictors,
  title = {{Predictors of physical performance decline in patients receiving maintenance hemodialysis: a prospective observational study}},
  author = {Elisângela Andrade Assis Madeira and Joyce Noelly Vitor Santos and Vitória Emanuelli Rodrigues Silva and Inara Caroline Marcelino Martins and Vanessa Gomes Brandão Rodrigues and Vanessa Kelly da Silva Lage and Ana Heloísa Santos Machado and Júlia Garcia de Castro Pereira and Frederico Lopes Alves and Maria Cecília Sales Mendes Prates and Emílio Henrique Barroso Maciel and Henrique Silveira Costa and Marcus Alessandro de Alcantara and Camila Danielle Cunha Neves and Regina Márcia Faria de Moura and Redha Taiar and Ana Cristina Rodrigues Lacerda and Pedro Henrique Scheidt Figueiredo and Vanessa Amaral Mendonça},
  journal = {BMC Nephrology},
  year = {2026},
  month = oct,
  doi = {10.1186/s12882-026-05361-7},
  url = {https://doi.org/10.1186/s12882-026-05361-7},
  note = {CC BY},
}

TY  - JOUR
TI  - Predictors of physical performance decline in patients receiving maintenance hemodialysis: a prospective observational study
AU  - Elisângela Andrade Assis Madeira
AU  - Joyce Noelly Vitor Santos
AU  - Vitória Emanuelli Rodrigues Silva
AU  - Inara Caroline Marcelino Martins
AU  - Vanessa Gomes Brandão Rodrigues
AU  - Vanessa Kelly da Silva Lage
AU  - Ana Heloísa Santos Machado
AU  - Júlia Garcia de Castro Pereira
AU  - Frederico Lopes Alves
AU  - Maria Cecília Sales Mendes Prates
AU  - Emílio Henrique Barroso Maciel
AU  - Henrique Silveira Costa
AU  - Marcus Alessandro de Alcantara
AU  - Camila Danielle Cunha Neves
AU  - Regina Márcia Faria de Moura
AU  - Redha Taiar
AU  - Ana Cristina Rodrigues Lacerda
AU  - Pedro Henrique Scheidt Figueiredo
AU  - Vanessa Amaral Mendonça
PY  - 2026
DA  - 2026/10/25
JO  - BMC Nephrology
DO  - 10.1186/s12882-026-05361-7
UR  - https://doi.org/10.1186/s12882-026-05361-7
AB  - Objective To identify predictors of physical performance decline in patients receiving maintenance hemodialysis. Methods This prospective observational study included patients receiving maintenance hemodialysis. Participants underwent assessment of physical performance using the Short Physical Performance Battery (SPPB), the 60-second sit-to-stand (60s-STS) test, handgrip strength, bone mineral density (BMD) by dual-energy X-ray absorptiometry (DEXA), and clinical and laboratory variables. Participants were classified according to changes in SPPB score between baseline and follow-up. The minimal detectable change (MDC) of the SPPB was used as the criterion for defining physical performance decline. Statistical analysis included Student’s t-test, the Mann–Whitney test, and chi-square tests. Univariable logistic regression and multivariable penalized logistic regression with Firth correction were used to identify predictors of physical performance decline. Results Of the 103 participants, 18 (17.5%) experienced physical performance decline after a mean follow-up of 18.6 ± 10.1 months. Compared with those who maintained physical performance, participants with physical performance decline were older and had lower total and femoral bone mineral density and poorer performance on the 60s-STS test at baseline. In the multivariable penalized logistic regression analysis, lower femoral BMD (OR: 0.997; 95% CI: 0.991–0.999) and longer hemodialysis vintage (OR: 1.009; 95% CI: 1.001–1.039) were independently associated with physical performance decline. Conclusion This prospective study showed that lower femoral bone mineral density and longer hemodialysis vintage were independently associated with physical performance decline in patients receiving maintenance hemodialysis. These findings underscore the potential value of longitudinal physical performance assessment and may help identify patients at greater risk of functional decline.
SN  - 1471-2369
ER  -