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Peer-reviewedCC BY-NCInternational journal of general medicine

Plasma Osteoprotegerin and Cardiovascular Mortality During the First Two Years of Maintenance Hemodialysis: A Prospective Observational Cohort Study.

  • Huu Dung Nguyen1,2
  • Anh Trung Hoang2,3
  • Trung Kien Nguyen4,5
  • Viet Thang Le2,6
6 affiliations
  1. 1Nephrology, Urology and Dialysis Center, Bach Mai Hospital, Hanoi, Vietnam.
  2. 2Department of Nephrology and Hemodialysis, Vietnam Military Medical University, Hanoi, Vietnam.
  3. 3Department of Hemodialysis, Phenikaa University Hospital, Hanoi, Vietnam.
  4. 4Hematology and Blood Transfusion Center, Military Hospital 103, Hanoi, Vietnam.
  5. 5Department of Hematology and Blood Transfusion, Vietnam Military Medical University, Hanoi, Vietnam.
  6. 6Organ Transplantation Center, Military Hospital 103, Hanoi, Vietnam.
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Abstract

Aim

We performed this study to determine the cardiovascular-cause mortality rate and the predictive value of the plasma osteoprotegerin (OPG) concentration for cardiovascular-cause mortality in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (MHD) during the first 2 years.Methods

We performed a prospective observational cohort study of 218 ESKD patients undergoing maintenance hemodialysis from September 2021 to September 2025. Plasma OPG concentrations were quantified using a colorimetric measurement method based on ELISA method. Cardiovascular-cause mortality data were collected over 2 years of follow-up. All patients were divided into 2 groups: the survival group (n = 187) and the mortality group (n = 31).Results

The incidence of cardiovascular-cause mortality was 14.2% over 2 years of follow-up. Compared with survivors, patients who died from cardiovascular causes had significantly lower HDL-C levels and higher PTH, hs-CRP, and OPG levels (p < 0.001). In multivariable Cox regression analysis, higher OPG levels were independently associated with increased cardiovascular mortality (HR = 1.050, p < 0.001). OPG showed good discriminatory performance for cardiovascular mortality (AUC = 0.828, p < 0.001), and Kaplan-Meier analysis demonstrated significantly higher mortality among patients with OPG levels > 47.95 pmol/L (log-rank p < 0.001).Conclusion

The cardiovascular-cause mortality rate during the first 2 years of maintenance hemodialysis was 14.2%. Plasma OPG levels are associated with cardiovascular mortality, suggesting its potential as a useful biomarker for risk stratification in ESKD patients.

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Cite

BibTeXRIS
BibTeX
@article{nguyen2026plasma,
  title = {{Plasma Osteoprotegerin and Cardiovascular Mortality During the First Two Years of Maintenance Hemodialysis: A Prospective Observational Cohort Study.}},
  author = {Huu Dung Nguyen and Anh Trung Hoang and Trung Kien Nguyen and Viet Thang Le},
  journal = {International journal of general medicine},
  year = {2026},
  month = oct,
  doi = {10.2147/ijgm.s652921},
  url = {https://europepmc.org/article/MED/42974514},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Plasma Osteoprotegerin and Cardiovascular Mortality During the First Two Years of Maintenance Hemodialysis: A Prospective Observational Cohort Study.
AU  - Huu Dung Nguyen
AU  - Anh Trung Hoang
AU  - Trung Kien Nguyen
AU  - Viet Thang Le
PY  - 2026
DA  - 2026/10/29
JO  - International journal of general medicine
DO  - 10.2147/ijgm.s652921
UR  - https://europepmc.org/article/MED/42974514
AB  - Aim  We performed this study to determine the cardiovascular-cause mortality rate and the predictive value of the plasma osteoprotegerin (OPG) concentration for cardiovascular-cause mortality in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (MHD) during the first 2 years.Methods  We performed a prospective observational cohort study of 218 ESKD patients undergoing maintenance hemodialysis from September 2021 to September 2025. Plasma OPG concentrations were quantified using a colorimetric measurement method based on ELISA method. Cardiovascular-cause mortality data were collected over 2 years of follow-up. All patients were divided into 2 groups: the survival group (n = 187) and the mortality group (n = 31).Results  The incidence of cardiovascular-cause mortality was 14.2% over 2 years of follow-up. Compared with survivors, patients who died from cardiovascular causes had significantly lower HDL-C levels and higher PTH, hs-CRP, and OPG levels (p < 0.001). In multivariable Cox regression analysis, higher OPG levels were independently associated with increased cardiovascular mortality (HR = 1.050, p < 0.001). OPG showed good discriminatory performance for cardiovascular mortality (AUC = 0.828, p < 0.001), and Kaplan-Meier analysis demonstrated significantly higher mortality among patients with OPG levels > 47.95 pmol/L (log-rank p < 0.001).Conclusion  The cardiovascular-cause mortality rate during the first 2 years of maintenance hemodialysis was 14.2%. Plasma OPG levels are associated with cardiovascular mortality, suggesting its potential as a useful biomarker for risk stratification in ESKD patients.
SN  - 1178-7074
ER  -