Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 23 min ago
Peer-reviewedCC BY-NC-NDJournal of otology

10-Minute vs. 4-Hour Post-Gadolinium 3D-FLAIR MRI for Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis.

  • Yiwen Liu1
  • Zitong Zhao1
  • Zuer Gong1
  • Jiaying Wu1
  • Lijun Wang1,2
  1. 1The First Clinical College, Dalian Medical University, Dalian, China.
  2. 2Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Read full textPDFDOICite

Abstract

The purpose of this study was to perform a meta-analysis comparing the performance of 10-minute and 4-hour delayed-enhanced Three-Dimensional Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging (3D-FLAIR MRI) for the detection of inner ear abnormalities in sudden sensorineural hearing loss (SSNHL). A comprehensive literature search was performed independently by two researchers, covering databases including PubMed, Web of Science, Science Direct and CNKI up to June 4, 2025. Original research studies comparing 10-minute and 4-hour delayed-enhanced 3D-FLAIR MRI in evaluating SSNHL were included. The Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data (JBI) was used for quality assessment. All literature was independently screened and data were extracted, followed by meta-analysis and subgroup analysis using RevMan 5.4 to compare the performance of 10-minute and 4-hour delayed-enhanced 3D-FLAIR MRI. Four studies including 211 affected ears in 210 SSNHL patients met inclusion criteria for the systematic review. All patients underwent 10-minute and 4-hour delayed-enhanced 3D-FLAIR MRI scanning. The meta-analysis showed a statistically significant difference in detection rates between the 10-minute and 4-hour delays (risk difference [RD], -0.24; 95% CI, -0.38 to -0.10; I2=63%; p=0.0006). Subgroup analyses indicated that study type, region and Gd dose may be the sources of heterogeneity. A 4-hour delay reveals 24% more abnormal findings than a 10-minute delay in Gd-enhanced 3D-FLAIR MRI. Therefore, we recommend a 4-hour delay for the clinical evaluation of SSNHL patients.

Related

  1. Efficacy of Defibrinogenation Therapy for Sudden Sensorineural Hearing Loss: A Systematic Review and Meta‐Analysis
    Jieun Shin, Jaekwang Lee, Jong Dai Kim +4
    Laryngoscope investigative otolaryngologyPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  2. Viral Etiology of Sudden Sensorineural Hearing Loss: Historical Development and Current Evidence.
    Shujie Zhao, Xiaozhou Liu, Xinyu Shi +2
    VirusesPeer-reviewedCC BYFull textNeurologyEurope PMC
  3. Case Report: A potential cardiovascular safety signal during batroxobin therapy for sudden sensorineural hearing loss: a three-case series of acute myocardial infarction
    Xin Zhuang, Tianen Pan, Kaiyu Hu +2
    Frontiers in Cardiovascular MedicinePeer-reviewedCC BY 4.0Full textCardiovascular medicineCrossrefDOAJ
  4. Pro-inflammatory diet association with sudden sensorineural hearing loss: a case-control study
    Kadir Sinasi Bulut, Basak Yalciner, Burak Celik +2
    The Journal of Laryngology and OtologyPeer-reviewedCC BY 4.0Full textNeurologyPMC
  5. Paired-ear tympanometric pressure patterns and hearing recovery in unilateral sudden sensorineural hearing loss: a retrospective cohort study
    Tianyu Zhang, Yaxue Xie, Yingxuan Li +7
    Frontiers in NeurologyPeer-reviewedCC BY 4.0Full textNeurologyCrossrefEurope PMCPMC

Cite

BibTeXRIS
BibTeX
@article{liu202610minute,
  title = {{10-Minute vs. 4-Hour Post-Gadolinium 3D-FLAIR MRI for Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis.}},
  author = {Yiwen Liu and Zitong Zhao and Zuer Gong and Jiaying Wu and Lijun Wang},
  journal = {Journal of otology},
  year = {2026},
  month = oct,
  doi = {10.26599/joto.2026.9540079},
  url = {https://europepmc.org/article/MED/42996919},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - 10-Minute vs. 4-Hour Post-Gadolinium 3D-FLAIR MRI for Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis.
AU  - Yiwen Liu
AU  - Zitong Zhao
AU  - Zuer Gong
AU  - Jiaying Wu
AU  - Lijun Wang
PY  - 2026
DA  - 2026/10/01
JO  - Journal of otology
DO  - 10.26599/joto.2026.9540079
UR  - https://europepmc.org/article/MED/42996919
AB  - The purpose of this study was to perform a meta-analysis comparing the performance of 10-minute and 4-hour delayed-enhanced Three-Dimensional Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging (3D-FLAIR MRI) for the detection of inner ear abnormalities in sudden sensorineural hearing loss (SSNHL). A comprehensive literature search was performed independently by two researchers, covering databases including PubMed, Web of Science, Science Direct and CNKI up to June 4, 2025. Original research studies comparing 10-minute and 4-hour delayed-enhanced 3D-FLAIR MRI in evaluating SSNHL were included. The Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data (JBI) was used for quality assessment. All literature was independently screened and data were extracted, followed by meta-analysis and subgroup analysis using RevMan 5.4 to compare the performance of 10-minute and 4-hour delayed-enhanced 3D-FLAIR MRI. Four studies including 211 affected ears in 210 SSNHL patients met inclusion criteria for the systematic review. All patients underwent 10-minute and 4-hour delayed-enhanced 3D-FLAIR MRI scanning. The meta-analysis showed a statistically significant difference in detection rates between the 10-minute and 4-hour delays (risk difference [RD], -0.24; 95% CI, -0.38 to -0.10; I2=63%; p=0.0006). Subgroup analyses indicated that study type, region and Gd dose may be the sources of heterogeneity. A 4-hour delay reveals 24% more abnormal findings than a 10-minute delay in Gd-enhanced 3D-FLAIR MRI. Therefore, we recommend a 4-hour delay for the clinical evaluation of SSNHL patients.
SN  - 1672-2930
SN  - 2524-1753
ER  -