Impact of inflammatory bowel disease on perioperative complications in patients undergoing hysterectomy.
5 affiliations
- 1Dongguan Songshan Lake Tungwah Hospital, Dongguan, 523000, China.
- 2Department of Pediatric Orthopedic, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, 510000, China.
- 3Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
- 4Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. [email protected].
- 5Dongguan Songshan Lake Tungwah Hospital, Dongguan, 523000, China. [email protected].
Abstract
Objective
The global prevalence of inflammatory bowel disease (IBD) is escalating rapidly, with its associated systemic inflammation and immune dysregulation potentially compromising surgical outcomes. Nevertheless, IBD's influence on perioperative complications following hysterectomy remains unreported. This investigation sought to examine the relationship between IBD and perioperative complications in hysterectomy patients utilizing the National Inpatient Sample database while analyzing associated risk factors.Methods
Data for patients who underwent hysterectomy between 2016 and 2022 were obtained from the National Inpatient Sample (NIS) database using International Classification of Diseases, Tenth Revision, Clinical Modification codes. Patients younger than 18 years were excluded. Patients were stratified according to the presence or absence of IBD, and demographic characteristics, hospital characteristics, comorbidities, and perioperative outcomes were compared between groups. Statistical analyses included Pearson's χ² test, Wilcoxon rank-sum test, and multivariable logistic regression.Results
Among 187,401 hysterectomy patients, 853 (0.46%) had comorbid IBD. The prevalence of IBD increased from 0.40% in 2016 to 0.51% in 2022. After multivariable adjustment, IBD was associated with higher odds of sepsis (OR = 3.060; 95% CI = 2.095-4.470), shock (OR = 3.031; 95% CI = 1.605-3.722), acute kidney injury (AKI) (OR = 1.643; 95% CI = 1.235-2.184), urinary tract infection (UTI) (OR = 1.882; 95% CI = 1.332-2.659), and in-hospital mortality (OR = 3.827; 95% CI = 1.855-7.893).Conclusions
IBD prevalence among hysterectomy patients increased over time. IBD was associated with higher odds of selected perioperative outcomes, including sepsis, shock, AKI, UTI, and in-hospital mortality. These associations should be interpreted cautiously given the retrospective administrative database design.
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BibTeX
@article{liu2026impact,
title = {{Impact of inflammatory bowel disease on perioperative complications in patients undergoing hysterectomy.}},
author = {Haihua Liu and Lihui Chen and Nanfeng Huang and Zifeng Wang and Hao Xie and Ming Chen},
journal = {BMC women's health},
year = {2026},
month = jul,
doi = {10.1186/s12905-026-04670-1},
url = {https://europepmc.org/article/MED/42894206},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Impact of inflammatory bowel disease on perioperative complications in patients undergoing hysterectomy.
AU - Haihua Liu
AU - Lihui Chen
AU - Nanfeng Huang
AU - Zifeng Wang
AU - Hao Xie
AU - Ming Chen
PY - 2026
DA - 2026/07/01
JO - BMC women's health
DO - 10.1186/s12905-026-04670-1
UR - https://europepmc.org/article/MED/42894206
AB - Objective The global prevalence of inflammatory bowel disease (IBD) is escalating rapidly, with its associated systemic inflammation and immune dysregulation potentially compromising surgical outcomes. Nevertheless, IBD's influence on perioperative complications following hysterectomy remains unreported. This investigation sought to examine the relationship between IBD and perioperative complications in hysterectomy patients utilizing the National Inpatient Sample database while analyzing associated risk factors.Methods Data for patients who underwent hysterectomy between 2016 and 2022 were obtained from the National Inpatient Sample (NIS) database using International Classification of Diseases, Tenth Revision, Clinical Modification codes. Patients younger than 18 years were excluded. Patients were stratified according to the presence or absence of IBD, and demographic characteristics, hospital characteristics, comorbidities, and perioperative outcomes were compared between groups. Statistical analyses included Pearson's χ² test, Wilcoxon rank-sum test, and multivariable logistic regression.Results Among 187,401 hysterectomy patients, 853 (0.46%) had comorbid IBD. The prevalence of IBD increased from 0.40% in 2016 to 0.51% in 2022. After multivariable adjustment, IBD was associated with higher odds of sepsis (OR = 3.060; 95% CI = 2.095-4.470), shock (OR = 3.031; 95% CI = 1.605-3.722), acute kidney injury (AKI) (OR = 1.643; 95% CI = 1.235-2.184), urinary tract infection (UTI) (OR = 1.882; 95% CI = 1.332-2.659), and in-hospital mortality (OR = 3.827; 95% CI = 1.855-7.893).Conclusions IBD prevalence among hysterectomy patients increased over time. IBD was associated with higher odds of selected perioperative outcomes, including sepsis, shock, AKI, UTI, and in-hospital mortality. These associations should be interpreted cautiously given the retrospective administrative database design.
SN - 1472-6874
ER -