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Peer-reviewedCC BY 4.0PLOS One

Nephroprotective and Gastroprotective potential of Aerva javanica (L.) green synthesized nanoparticles, supported by Molecular Networking

  • Hany G. Attia1
  • Dalia H. Abu-Baih2
  • Bassam S. M. Al kazman3
  • A. Maqboul4
  • Mohamed A. Rabeh5
  • Saad Ali Alshehri6
  • Ali Al-shabi7
  • Mohamed A. Zarka8
  • Sameh S. Zaghlool9
  • Fatma Alzahraa Mokhtar10
  • Nehad M. Reda Abdel-maqsoud11
  • Usama Ramadan Abdelmohsen
1 more authors
  • Khayrya A. Youssif
11 affiliations
  1. 1Department of Pharmacognosy, College of Pharmacy, Najran University, Najran, Saudi Arabia
  2. 2Health Research Center, Najran University, Najran, Saudi Arabia
  3. 3Department of Biochemistry & Molecular Biology, Faculty of Pharmacy, Deraya University, Minia, Egypt
  4. 4Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia
  5. 5Department of Pharmacognosy, College of Pharmacy, King Khalid, Abha, Saudi Arabia
  6. 6Department of Pharmacognosy and Phytochemistry, College of Pharmacy, The Islamic University, Najaf, Iraq
  7. 7Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Mokattam, Cairo, Egypt
  8. 8Department of Pharmacognosy, Faculty of Pharmacy, El Saleheya El Gadida university, Sharkia, Egypt
  9. 9Department of Pathology, Deraya University, Universities Zone, New Minia City, Egypt
  10. 10Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
  11. 11Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Minia, Egypt
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Abstract

NSAIDs pose a significant risk to the stomach and kidneys, with oxidative stress being a key driver in the development of indomethacin-induced gastric ulcers and acute kidney injury by disrupting the balance between oxidation and antioxidation. Effective management of oxidative stress and bolstering antioxidant defenses are crucial strategies for preventing and treating these conditions. This study explored the potential of Aerva javanica, a plant abundant in Saudi Arabia and used in traditional medicine, to mitigate these adverse effects. Researchers identified 27 phytochemicals in its leaf extract using LC-MS and synthesized silver nanoparticles (SNPs), characterizing them with TEM and UV-visible spectrophotometry. Network analysis suggested a link between procyanidin dimer and kaempferol 4’-O-methyl ether with genes protecting the kidneys and stomach, possibly involving the AGE-RAGE and HIF-1 signaling pathways. In vivo experiments using an indomethacin-induced injury model demonstrated that administering A. javanica resulted in a dose-dependent decrease in gastric ulcer severity and a return of elevated serum renal markers to normal levels. Furthermore, the treatment reduced oxidative stress markers (MDA) and increased antioxidant levels (GSH) in both the stomach and kidneys. A. javanica also suppressed the expression of pro-inflammatory markers and inhibited the NF-κB p65 and STAT-3 signaling pathways. Histological examination corroborated these protective effects. The observed scavenging activity of A. javanica is attributed to its rich content of flavonoids and phenolic compounds. These findings suggest that A. javanica offers promising gastroprotective and nephroprotective properties against NSAID-induced complications by reducing oxidative stress and inflammation through the coordinated regulation of key signaling pathways.

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Cite

BibTeXRIS
BibTeX
@article{attia2026nephroprotective,
  title = {{Nephroprotective and Gastroprotective potential of Aerva javanica (L.) green synthesized nanoparticles, supported by Molecular Networking}},
  author = {Hany G. Attia and Dalia H. Abu-Baih and Bassam S. M. Al kazman and A. Maqboul and Mohamed A. Rabeh and Saad Ali Alshehri and Ali Al-shabi and Mohamed A. Zarka and Sameh S. Zaghlool and Fatma Alzahraa Mokhtar and Nehad M. Reda Abdel-maqsoud and Usama Ramadan Abdelmohsen and Khayrya A. Youssif},
  journal = {PLOS One},
  year = {2026},
  month = nov,
  doi = {10.1371/journal.pone.0358843},
  url = {https://doi.org/10.1371/journal.pone.0358843},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Nephroprotective and Gastroprotective potential of Aerva javanica (L.) green synthesized nanoparticles, supported by Molecular Networking
AU  - Hany G. Attia
AU  - Dalia H. Abu-Baih
AU  - Bassam S. M. Al kazman
AU  - A. Maqboul
AU  - Mohamed A. Rabeh
AU  - Saad Ali Alshehri
AU  - Ali Al-shabi
AU  - Mohamed A. Zarka
AU  - Sameh S. Zaghlool
AU  - Fatma Alzahraa Mokhtar
AU  - Nehad M. Reda Abdel-maqsoud
AU  - Usama Ramadan Abdelmohsen
AU  - Khayrya A. Youssif
PY  - 2026
DA  - 2026/11/05
JO  - PLOS One
DO  - 10.1371/journal.pone.0358843
UR  - https://doi.org/10.1371/journal.pone.0358843
AB  - NSAIDs pose a significant risk to the stomach and kidneys, with oxidative stress being a key driver in the development of indomethacin-induced gastric ulcers and acute kidney injury by disrupting the balance between oxidation and antioxidation. Effective management of oxidative stress and bolstering antioxidant defenses are crucial strategies for preventing and treating these conditions. This study explored the potential of Aerva javanica, a plant abundant in Saudi Arabia and used in traditional medicine, to mitigate these adverse effects. Researchers identified 27 phytochemicals in its leaf extract using LC-MS and synthesized silver nanoparticles (SNPs), characterizing them with TEM and UV-visible spectrophotometry. Network analysis suggested a link between procyanidin dimer and kaempferol 4’-O-methyl ether with genes protecting the kidneys and stomach, possibly involving the AGE-RAGE and HIF-1 signaling pathways. In vivo experiments using an indomethacin-induced injury model demonstrated that administering A. javanica resulted in a dose-dependent decrease in gastric ulcer severity and a return of elevated serum renal markers to normal levels. Furthermore, the treatment reduced oxidative stress markers (MDA) and increased antioxidant levels (GSH) in both the stomach and kidneys. A. javanica also suppressed the expression of pro-inflammatory markers and inhibited the NF-κB p65 and STAT-3 signaling pathways. Histological examination corroborated these protective effects. The observed scavenging activity of A. javanica is attributed to its rich content of flavonoids and phenolic compounds. These findings suggest that A. javanica offers promising gastroprotective and nephroprotective properties against NSAID-induced complications by reducing oxidative stress and inflammation through the coordinated regulation of key signaling pathways.
SN  - 1932-6203
ER  -