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Peer-reviewedCC BY-NCMaterials today. Bio

Injectable self-healing polysaccharide hydrogel with slow-release b-FGF for adipose tissue regeneration.

  • Shuhan Wu1
  • Wenjun Shu2
  • Xulong Zhu1
  • Yong Mei Chen3
  • Zhenxiu Liu3
  • Yue Wang1
  • Hengtao Song4
  • Dong Xiao2
  • Chao Zhai2
  • Nan Jiang1
  • Jianhui Li1
4 affiliations
  1. 1Department of Surgical Oncology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China.
  2. 2Department of Surgical Oncology, 3201 Hospital, Hanzhong, Shaanxi, 723000, China.
  3. 3College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an, Shaanxi, 710021, China.
  4. 4Department of General Surgery, Ankang Hospital of Traditional Chinese Medicine, Ankang, Shaanxi, 725000, China.
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Abstract

Soft tissue defects require the application of adipose tissue reconstruction techniques; however, these approaches often face challenges such as low survival rates due to mechanical pressure and inadequate blood supply. This study presents the development of an injectable, self-healing polysaccharide hydrogel designed for the slow release of basic fibroblast growth factor (b-FGF) that utilizes oxidized hyaluronic acid (OHA) and carbohydrazide-modified gelatin (Gel-CDH) as foundational components. The hydrogel is characterized by an optimal pore size, porosity, mechanical properties, and degradation behavior, in addition to excellent biocompatibility, all of which facilitate adipose tissue growth. In vitro experiments revealed that the OHA/Gel-CDH polysaccharide hydrogel significantly enhanced the adipogenic differentiation of adipose-derived stem cells. Furthermore, the implantation of the polysaccharide hydrogel in conjunction with an autologous fat graft suspension into the subcutaneous of the rat dorsal region resulted in improved adipose tissue survival and the regeneration of vascularized adipose tissue. These results suggest that the use of an injectable, self-healing OHA/Gel-CDH polysaccharide hydrogel with slow-released b-FGF in combination with autologous fat grafting is a promising strategy for the repair of soft tissue defects.

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Cite

BibTeXRIS
BibTeX
@article{wu2026injectable,
  title = {{Injectable self-healing polysaccharide hydrogel with slow-release b-FGF for adipose tissue regeneration.}},
  author = {Shuhan Wu and Wenjun Shu and Xulong Zhu and Yong Mei Chen and Zhenxiu Liu and Yue Wang and Hengtao Song and Dong Xiao and Chao Zhai and Nan Jiang and Jianhui Li},
  journal = {Materials today. Bio},
  year = {2026},
  month = oct,
  doi = {10.1016/j.mtbio.2026.103739},
  url = {https://europepmc.org/article/MED/42903678},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Injectable self-healing polysaccharide hydrogel with slow-release b-FGF for adipose tissue regeneration.
AU  - Shuhan Wu
AU  - Wenjun Shu
AU  - Xulong Zhu
AU  - Yong Mei Chen
AU  - Zhenxiu Liu
AU  - Yue Wang
AU  - Hengtao Song
AU  - Dong Xiao
AU  - Chao Zhai
AU  - Nan Jiang
AU  - Jianhui Li
PY  - 2026
DA  - 2026/10/08
JO  - Materials today. Bio
DO  - 10.1016/j.mtbio.2026.103739
UR  - https://europepmc.org/article/MED/42903678
AB  - Soft tissue defects require the application of adipose tissue reconstruction techniques; however, these approaches often face challenges such as low survival rates due to mechanical pressure and inadequate blood supply. This study presents the development of an injectable, self-healing polysaccharide hydrogel designed for the slow release of basic fibroblast growth factor (b-FGF) that utilizes oxidized hyaluronic acid (OHA) and carbohydrazide-modified gelatin (Gel-CDH) as foundational components. The hydrogel is characterized by an optimal pore size, porosity, mechanical properties, and degradation behavior, in addition to excellent biocompatibility, all of which facilitate adipose tissue growth. In vitro experiments revealed that the OHA/Gel-CDH polysaccharide hydrogel significantly enhanced the adipogenic differentiation of adipose-derived stem cells. Furthermore, the implantation of the polysaccharide hydrogel in conjunction with an autologous fat graft suspension into the subcutaneous of the rat dorsal region resulted in improved adipose tissue survival and the regeneration of vascularized adipose tissue. These results suggest that the use of an injectable, self-healing OHA/Gel-CDH polysaccharide hydrogel with slow-released b-FGF in combination with autologous fat grafting is a promising strategy for the repair of soft tissue defects.
SN  - 2590-0064
ER  -