Box C/D SNORD116-17 promotes prostate cancer progression by targeting the miR-206/E2F5 axis
Abstract
Small nucleolar RNAs (snoRNAs) are single-stranded non-coding RNAs found in eukaryotic nucleolus, and their aberrant expression is closely related to tumorigenesis. Box C/D SNORD116-17, a member of SNORD116 cluster, is highly expressed in prostate cancer tissues, though its biological function in this malignancy remains uncharacterized. Here, we found that SNORD116-17 is evident, stable, and highly expressed in prostate cancer cells and that its overexpression significantly promoted the proliferation, migration, and invasion of cancer cells. Bioinformatics prediction, RIP, RNA dot blot, and RNA-protein pulldown experiments revealed that miR-206 interacted with SNORD116-17, forming a complex with Argonaute 2. Subsequently, PCR and western blot experiments revealed that both miR-206 and SNORD116-17 regulated the expression of E2F transcription factor 5 (E2F5), a commonly studied oncogene in prostate cancer. In summary, SNORD116-17 contributes to prostate cancer progression by sponging with miR-206 through the ceRNA mechanism and upregulating the expression of E2F5.
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BibTeX
@article{pan2026snord11617,
title = {{Box C/D SNORD116-17 promotes prostate cancer progression by targeting the miR-206/E2F5 axis}},
author = {Xiuyi Pan and Yifan Kang and Jinjing Zhong and Ting Yu and Linmao Zheng and Yuyan Wei and Junya Tan and Ling Nie and Mengni Zhang and Ni Chen and Qiao Zhou and Xueqin Chen},
journal = {iScience},
year = {2026},
month = oct,
doi = {10.1016/j.isci.2026.117806},
url = {https://www.cell.com/iscience/fulltext/S2589-0042(26)03187-1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Box C/D SNORD116-17 promotes prostate cancer progression by targeting the miR-206/E2F5 axis
AU - Xiuyi Pan
AU - Yifan Kang
AU - Jinjing Zhong
AU - Ting Yu
AU - Linmao Zheng
AU - Yuyan Wei
AU - Junya Tan
AU - Ling Nie
AU - Mengni Zhang
AU - Ni Chen
AU - Qiao Zhou
AU - Xueqin Chen
PY - 2026
DA - 2026/10/08
JO - iScience
DO - 10.1016/j.isci.2026.117806
UR - https://www.cell.com/iscience/fulltext/S2589-0042(26)03187-1
AB - Small nucleolar RNAs (snoRNAs) are single-stranded non-coding RNAs found in eukaryotic nucleolus, and their aberrant expression is closely related to tumorigenesis. Box C/D SNORD116-17, a member of SNORD116 cluster, is highly expressed in prostate cancer tissues, though its biological function in this malignancy remains uncharacterized. Here, we found that SNORD116-17 is evident, stable, and highly expressed in prostate cancer cells and that its overexpression significantly promoted the proliferation, migration, and invasion of cancer cells. Bioinformatics prediction, RIP, RNA dot blot, and RNA-protein pulldown experiments revealed that miR-206 interacted with SNORD116-17, forming a complex with Argonaute 2. Subsequently, PCR and western blot experiments revealed that both miR-206 and SNORD116-17 regulated the expression of E2F transcription factor 5 (E2F5), a commonly studied oncogene in prostate cancer. In summary, SNORD116-17 contributes to prostate cancer progression by sponging with miR-206 through the ceRNA mechanism and upregulating the expression of E2F5.
SN - 2589-0042
ER -