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PreprintCC BYChemRxiv

Electrochemical Detection of Ethanol in Liquid Samples and Simulated Breath: Investigating Calibration, Selectivity, and Preconcentration

  • Benjamin Nelson1,2
  • Keya Pandey1,2
  • Oliver Powell1,2
  • Setareh Soureshjani3,4
  • Lida Khalafi3,4
  • Mahsa Hosseini5,6
  • Mohammad Rafiee1,2
6 affiliations
  1. 1Division of Energy, Matter and Systems, School of Science and Engineering
  2. 2University of Missouri−Kansas City
  3. 3College of Arts and Sciences
  4. 4Avila University
  5. 5Division of Behavioral, Natural and Health Sciences
  6. 6William Jewell College
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Abstract

Advances in miniaturized and point-of-care electrochemical sensors have expanded their applications in healthcare, environmental monitoring, and public safety. Consequently, it is important to study the principles of these technologies in an undergraduate setting. This experiment uses screen-printed electrodes for electrochemical detection of ethanol and introduces students to electrocatalysis, calibration curves, chemical interference, selectivity, and preconcentration. Students use cyclic voltammetry and chronoamperometry to make calibration curves and determine ethanol concentrations in ethanol standards and diluted beer and wine samples. Glucose interference is investigated, and a simulated breath experiment demonstrates how selecting breath as the analytical sample and condensing it can eliminate interference while simultaneously preconcentrating ethanol. The activity provides an opportunity to discuss blood alcohol concentration (BAC), breath alcohol concentration (BrAC), and modern alcohol-sensing technologies. This experiment is suitable for upper-level undergraduate courses in analytical chemistry, physical chemistry, and electrochemistry.

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Cite

BibTeXRIS
BibTeX
@misc{nelson2026electrochemical,
  title = {{Electrochemical Detection of Ethanol in Liquid Samples and Simulated Breath: Investigating Calibration, Selectivity, and Preconcentration}},
  author = {Benjamin Nelson and Keya Pandey and Oliver Powell and Setareh Soureshjani and Lida Khalafi and Mahsa Hosseini and Mohammad Rafiee},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010028/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010028/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Electrochemical Detection of Ethanol in Liquid Samples and Simulated Breath: Investigating Calibration, Selectivity, and Preconcentration
AU  - Benjamin Nelson
AU  - Keya Pandey
AU  - Oliver Powell
AU  - Setareh Soureshjani
AU  - Lida Khalafi
AU  - Mahsa Hosseini
AU  - Mohammad Rafiee
PY  - 2026
DA  - 2026/10/07
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010028/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010028/v1
AB  - Advances in miniaturized and point-of-care electrochemical sensors have expanded their applications in healthcare, environmental monitoring, and public safety. Consequently, it is important to study the principles of these technologies in an undergraduate setting. This experiment uses screen-printed electrodes for electrochemical detection of ethanol and introduces students to electrocatalysis, calibration curves, chemical interference, selectivity, and preconcentration. Students use cyclic voltammetry and chronoamperometry to make calibration curves and determine ethanol concentrations in ethanol standards and diluted beer and wine samples. Glucose interference is investigated, and a simulated breath experiment demonstrates how selecting breath as the analytical sample and condensing it can eliminate interference while simultaneously preconcentrating ethanol. The activity provides an opportunity to discuss blood alcohol concentration (BAC), breath alcohol concentration (BrAC), and modern alcohol-sensing technologies. This experiment is suitable for upper-level undergraduate courses in analytical chemistry, physical chemistry, and electrochemistry.
ER  -