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Peer-reviewedCC BY-NCChemical and Pharmaceutical Bulletin

Development of an Efficient Synthetic Method for Nitrogen-Containing Heterocyclic Primary Sulfonamides

  • Masahiro Abe
  • Misaki Furukawa
  • Minji Lee
  • Akiho Mizukami
  • Kiyofumi Inamoto
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Abstract

A gas-free, one-pot synthesis of heterocyclic primary sulfonamides from heterocyclic thiols is described. This method employs sodium hypochlorite pentahydrate as a solid chlorinating source and aqueous ammonia as a nitrogen source, avoiding hazardous chlorine and ammonia gases. The protocol was applied to a range of pyrimidine, pyridine, benzothiazole, and tetrazole derivatives. The utility of this method was further demonstrated by 15N-labeling and multigram-scale synthesis.

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Cite

BibTeXRIS
BibTeX
@article{abe2026development,
  title = {{Development of an Efficient Synthetic Method for Nitrogen-Containing Heterocyclic Primary Sulfonamides}},
  author = {Masahiro Abe and Misaki Furukawa and Minji Lee and Akiho Mizukami and Kiyofumi Inamoto},
  journal = {Chemical and Pharmaceutical Bulletin},
  year = {2026},
  month = jul,
  doi = {10.1248/cpb.c26-00250},
  url = {https://www.jstage.jst.go.jp/article/cpb/74/7/74_c26-00250/_article},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Development of an Efficient Synthetic Method for Nitrogen-Containing Heterocyclic Primary Sulfonamides
AU  - Masahiro Abe
AU  - Misaki Furukawa
AU  - Minji Lee
AU  - Akiho Mizukami
AU  - Kiyofumi Inamoto
PY  - 2026
DA  - 2026/07/24
JO  - Chemical and Pharmaceutical Bulletin
DO  - 10.1248/cpb.c26-00250
UR  - https://www.jstage.jst.go.jp/article/cpb/74/7/74_c26-00250/_article
AB  - A gas-free, one-pot synthesis of heterocyclic primary sulfonamides from heterocyclic thiols is described. This method employs sodium hypochlorite pentahydrate as a solid chlorinating source and aqueous ammonia as a nitrogen source, avoiding hazardous chlorine and ammonia gases. The protocol was applied to a range of pyrimidine, pyridine, benzothiazole, and tetrazole derivatives. The utility of this method was further demonstrated by 15N-labeling and multigram-scale synthesis.
SN  - 1347-5223
SN  - 0009-2363
ER  -