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Peer-reviewedCC BY-NCRSC advances

Trends towards multidrug-resistant bacteria: heterocyclic compounds containing antimicrobial agents: review

  • Fatma A. M. Mohamed1
  • Amira A. E. Satti2
  • Hemat S. Khalaf3
  • Ahmed A. Fayed3
  1. 1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University Sakaka 72388 Saudi Arabia
  2. 2Department of Chemistry, College of Science, Jouf University Sakaka Aljouf 72341 Saudi Arabia
  3. 3Photochemistry Department, Chemical Industries Research Institute, National Research Centre Cairo Egypt
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Abstract

The rapid emergence of multidrug-resistant (MDR) pathogens poses a severe global health threat, as current antibiotics become increasingly ineffective due to antimicrobial resistance (AMR), irrational drug use across human, veterinary, and agricultural sectors, and aggressive pharmaceutical marketing. This crisis is further aggravated by a shortage of novel antibacterial agents entering clinical practice, highlighting the urgent need for new treatment modalities and drug repurposing strategies. In response, heterocyclic compounds have emerged as a highly versatile and promising class of organic molecules with unique broad-spectrum antibacterial activity against both Gram-positive and Gram-negative strains. To successfully translate these bench discoveries into clinical solutions against superbugs, a combined approach integrating rigorous antibiotic stewardship principles with streamlined regulatory pathways is essential.

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Cite

BibTeXRIS
BibTeX
@article{mohamed2026trends,
  title = {{Trends towards multidrug-resistant bacteria: heterocyclic compounds containing antimicrobial agents: review}},
  author = {Fatma A. M. Mohamed and Amira A. E. Satti and Hemat S. Khalaf and Ahmed A. Fayed},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra06419a},
  url = {https://europepmc.org/article/PMC/PMC13656222},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Trends towards multidrug-resistant bacteria: heterocyclic compounds containing antimicrobial agents: review
AU  - Fatma A. M. Mohamed
AU  - Amira A. E. Satti
AU  - Hemat S. Khalaf
AU  - Ahmed A. Fayed
PY  - 2026
DA  - 2026/10/12
JO  - RSC advances
DO  - 10.1039/d6ra06419a
UR  - https://europepmc.org/article/PMC/PMC13656222
AB  - The rapid emergence of multidrug-resistant (MDR) pathogens poses a severe global health threat, as current antibiotics become increasingly ineffective due to antimicrobial resistance (AMR), irrational drug use across human, veterinary, and agricultural sectors, and aggressive pharmaceutical marketing. This crisis is further aggravated by a shortage of novel antibacterial agents entering clinical practice, highlighting the urgent need for new treatment modalities and drug repurposing strategies. In response, heterocyclic compounds have emerged as a highly versatile and promising class of organic molecules with unique broad-spectrum antibacterial activity against both Gram-positive and Gram-negative strains. To successfully translate these bench discoveries into clinical solutions against superbugs, a combined approach integrating rigorous antibiotic stewardship principles with streamlined regulatory pathways is essential.
SN  - 2046-2069
ER  -