TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs
Abstract
Thymic stromal lymphopoietin (TSLP), initially described as a driver of type 2 helper T cell responses, can also act on dendritic cells (DCs) to promote the generation and accumulation of GATA3-expressing effector regulatory T (eTreg) cells in the context of cutaneous melanoma. In this study, using an experimental mouse model with induced TSLP expression by epidermal keratinocytes combined with genetic tools, we find that TSLP drives GATA3+ eTreg cells through a specific migratory DC population where the co-stimulatory molecule OX40L is required. By conducting transcriptomic identity, lineage-traced ontogeny, surface marker expression and functional studies, we identified and characterized this DC population. Our data demonstrated that TSLP acts on transitional dendritic cell-derived DC2 to promote GATA3+ eTreg cells, thus uncovering a previously unrecognized tolerogenic axis in promoting immunosuppression, which is likely conserved in humans, across contexts of inflammation and cancer
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BibTeX
@article{guivarch2026tslp,
title = {{TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs}},
author = {Marine Guivarch and Pierre Meyer and Antoine Braud and Pierre Marschall and Alicia Perrin and Alexis Verdenet and Thien Phong Vu Manh and Pauline Santa and Vanja Sisirak and Ya-Li Zhang and Eric Flatter and Tao Ye and Matthieu Jung and Marie-Christine Birling and Pierre Hener and Justine Segaud and Beatriz German and Dan Lipsker and Marc Dalod and Mei Li},
journal = {Nature Immunology},
year = {2026},
month = oct,
doi = {10.1038/s41590-025-02400-7},
url = {https://hal.science/hal-05619972v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs
AU - Marine Guivarch
AU - Pierre Meyer
AU - Antoine Braud
AU - Pierre Marschall
AU - Alicia Perrin
AU - Alexis Verdenet
AU - Thien Phong Vu Manh
AU - Pauline Santa
AU - Vanja Sisirak
AU - Ya-Li Zhang
AU - Eric Flatter
AU - Tao Ye
AU - Matthieu Jung
AU - Marie-Christine Birling
AU - Pierre Hener
AU - Justine Segaud
AU - Beatriz German
AU - Dan Lipsker
AU - Marc Dalod
AU - Mei Li
PY - 2026
DA - 2026/10/29
JO - Nature Immunology
DO - 10.1038/s41590-025-02400-7
UR - https://hal.science/hal-05619972v1
AB - Thymic stromal lymphopoietin (TSLP), initially described as a driver of type 2 helper T cell responses, can also act on dendritic cells (DCs) to promote the generation and accumulation of GATA3-expressing effector regulatory T (eTreg) cells in the context of cutaneous melanoma. In this study, using an experimental mouse model with induced TSLP expression by epidermal keratinocytes combined with genetic tools, we find that TSLP drives GATA3+ eTreg cells through a specific migratory DC population where the co-stimulatory molecule OX40L is required. By conducting transcriptomic identity, lineage-traced ontogeny, surface marker expression and functional studies, we identified and characterized this DC population. Our data demonstrated that TSLP acts on transitional dendritic cell-derived DC2 to promote GATA3+ eTreg cells, thus uncovering a previously unrecognized tolerogenic axis in promoting immunosuppression, which is likely conserved in humans, across contexts of inflammation and cancer
SN - 1529-2908
SN - 1529-2916
ER -