VACCINATION HISTORY AND SEROLOGICAL PROFILE OF INDIVIDUALS DIAGNOSED WITH HEPATITIS B AT A MUNICIPAL LABORATORY IN MANAUS, AMAZONAS
- 1Universidade do Estado do Amazonas (UEA), Manaus, Brazil
- 2Secretaria Municipal de Saúde de Manaus (SEMSA), Manaus, Brazil
Abstract
Introduction: Hepatitis B remains a major public health concern, particularly in Northern Brazil, despite the availability of a safe and effective vaccine. Evaluating the vaccination history of individuals diagnosed with hepatitis B may identify gaps in immunization records and support epidemiological surveillance, contributing to the strengthening of disease prevention and control strategies. Objective: To evaluate the vaccination history of individuals diagnosed with hepatitis B at a municipal laboratory in Manaus, describing its distribution according to serological profile and sociodemographic characteristics. Materials and methods: This observational, retrospective, cross-sectional study was conducted using laboratory and epidemiological data from individuals who underwent serological testing for hepatitis B at the Professor Manoel Bastos Lira Northern District Laboratory, Manaus, Amazonas, between August 2024 and April 2026. Laboratory data from the SoftLab system were integrated with records from the Brazilian Notifiable Diseases Information System (SINAN) to obtain vaccination history and complement epidemiological information. Serological profiles were characterized using HBsAg, total anti-HBc, anti-HBc IgM, and anti-HBs markers. Among individuals with reactive HBsAg results, sex, age, race/ethnicity, occupation, pregnancy status, serological classification, and vaccination history were evaluated. Vaccination history was categorized as complete vaccination schedule, incomplete vaccination schedule, unvaccinated, unknown, or no vaccination record. Data were analyzed using descriptive statistics. Results: A total of 11,438 individuals underwent HBsAg testing. After applying the exclusion criteria, 74 reactive cases remained for analysis, corresponding to a positivity rate of 0.65%. Among positive cases, the predominant serological profile was compatible with chronic infection (75.68%), and no cases were classified as acute hepatitis B. Most cases occurred among females (68.9%) and individuals aged 18–40 years (50.0%). Pregnant women accounted for 24.3% of the analyzed cases. Regarding vaccination history, most individuals had no vaccination record (60.8%), followed by unknown vaccination status (16.2%), unvaccinated individuals (14.9%), incomplete vaccination schedule (5.4%), and complete vaccination schedule (2.7%). Conclusion: The high frequency of missing or incomplete vaccination records among individuals diagnosed with hepatitis B limits the characterization of the vaccination status of this population. Strengthening the integration of immunization, epidemiological surveillance, and laboratory information systems may improve vaccination monitoring, support public health interventions, and enhance hepatitis B control strategies in the state of Amazonas.
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BibTeX
@article{costa2026vaccination,
title = {{VACCINATION HISTORY AND SEROLOGICAL PROFILE OF INDIVIDUALS DIAGNOSED WITH HEPATITIS B AT A MUNICIPAL LABORATORY IN MANAUS, AMAZONAS}},
author = {Manoel Palhano COSTA and Renzo Vasquez FLORES and Sarah Leticia Izidro PINTO and Erick Frota Gomes FIGUEIREDO and Cristina Melo ROCHA and Isabella MOTTA-PASSOS},
journal = {Hematology, Transfusion and Cell Therapy},
year = {2026},
month = oct,
doi = {10.1016/j.htct.2026.107173},
url = {https://doi.org/10.1016/j.htct.2026.107173},
note = {CC BY},
}
RIS
TY - JOUR
TI - VACCINATION HISTORY AND SEROLOGICAL PROFILE OF INDIVIDUALS DIAGNOSED WITH HEPATITIS B AT A MUNICIPAL LABORATORY IN MANAUS, AMAZONAS
AU - Manoel Palhano COSTA
AU - Renzo Vasquez FLORES
AU - Sarah Leticia Izidro PINTO
AU - Erick Frota Gomes FIGUEIREDO
AU - Cristina Melo ROCHA
AU - Isabella MOTTA-PASSOS
PY - 2026
DA - 2026/10/23
JO - Hematology, Transfusion and Cell Therapy
DO - 10.1016/j.htct.2026.107173
UR - https://doi.org/10.1016/j.htct.2026.107173
AB - Introduction: Hepatitis B remains a major public health concern, particularly in Northern Brazil, despite the availability of a safe and effective vaccine. Evaluating the vaccination history of individuals diagnosed with hepatitis B may identify gaps in immunization records and support epidemiological surveillance, contributing to the strengthening of disease prevention and control strategies. Objective: To evaluate the vaccination history of individuals diagnosed with hepatitis B at a municipal laboratory in Manaus, describing its distribution according to serological profile and sociodemographic characteristics. Materials and methods: This observational, retrospective, cross-sectional study was conducted using laboratory and epidemiological data from individuals who underwent serological testing for hepatitis B at the Professor Manoel Bastos Lira Northern District Laboratory, Manaus, Amazonas, between August 2024 and April 2026. Laboratory data from the SoftLab system were integrated with records from the Brazilian Notifiable Diseases Information System (SINAN) to obtain vaccination history and complement epidemiological information. Serological profiles were characterized using HBsAg, total anti-HBc, anti-HBc IgM, and anti-HBs markers. Among individuals with reactive HBsAg results, sex, age, race/ethnicity, occupation, pregnancy status, serological classification, and vaccination history were evaluated. Vaccination history was categorized as complete vaccination schedule, incomplete vaccination schedule, unvaccinated, unknown, or no vaccination record. Data were analyzed using descriptive statistics. Results: A total of 11,438 individuals underwent HBsAg testing. After applying the exclusion criteria, 74 reactive cases remained for analysis, corresponding to a positivity rate of 0.65%. Among positive cases, the predominant serological profile was compatible with chronic infection (75.68%), and no cases were classified as acute hepatitis B. Most cases occurred among females (68.9%) and individuals aged 18–40 years (50.0%). Pregnant women accounted for 24.3% of the analyzed cases. Regarding vaccination history, most individuals had no vaccination record (60.8%), followed by unknown vaccination status (16.2%), unvaccinated individuals (14.9%), incomplete vaccination schedule (5.4%), and complete vaccination schedule (2.7%). Conclusion: The high frequency of missing or incomplete vaccination records among individuals diagnosed with hepatitis B limits the characterization of the vaccination status of this population. Strengthening the integration of immunization, epidemiological surveillance, and laboratory information systems may improve vaccination monitoring, support public health interventions, and enhance hepatitis B control strategies in the state of Amazonas.
SN - 2531-1379
SN - 2531-1387
ER -