Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 25 min ago
Peer-reviewedCC BY 4.0Metabolites

Pregestational Body Mass Index Is Associated with Differential Expression of ABC Transporter in the Maternal–Neonatal Dyad

  • America Vanoye-Carlo1
  • Sandra Berenice Parra-Hernandez2
  • Ameyalli M. Rodríguez-Cano3
  • Otilia Perichart-Perera3
  • Mari Cruz Tolentino-Dolores3
  • Marco Cerbón4
  • Oscar A. Perez-González1
  • Sonia Nava-Salazar2
4 affiliations
  1. 1Laboratorio de Oncología Experimental, Instituto Nacional de Pediatría, SSA., Mexico City 04530, Mexico
  2. 2Departamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
  3. 3Coordinación de Nutrición y Bioprogramación, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
  4. 4Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
Read full textPDFDOICite

Abstract

Background: Maternal obesity has been associated with fetal growth abnormalities and alterations in metabolic programming. ATP-binding cassette transporters, including ABCA1, ABCG1, ABCC1 and ABCG2, play essential roles in cholesterol homeostasis and placental function, fetal growth and development. However, the regulation of these transporters in the maternal–fetal axis under metabolic stress remains poorly understood. Methods: We evaluated 92 mother–newborn pairs, stratified by pregestational body mass index into three groups: normal weight (n = 34), overweight (n = 35) and obese (n = 23). Metabolic profiles and ABCA1, ABCG1, ABCC1 and ABCG2 mRNA expression in peripheral blood mononuclear cells were assessed. Results: Obese mothers demonstrated significantly higher TyG-BMI indices compared to normal-weight women. Regarding transporter expression, ABCA1 levels were elevated, while ABCG1 and ABCG2 were significantly downregulated in both overweight and obese mothers and their newborns. Positive correlations were observed between maternal and neonatal ABCA1. Maternal metabolic status correlated with ABC transporter expression, as demonstrated by inverse relationships between fasting glucose and maternal ABCA1 expression and between cholesterol levels and maternal ABCG2 expression. Furthermore, ABCG1 and ABCG2 expression levels positively correlated with fetal growth parameters. Conclusions: Maternal overweight and obesity before pregnancy were associated with significant changes in the expression of key ABC transporters in both mothers and their newborns. Changes in maternal ABCA1 and ABCG1 expression could be related to altered cholesterol homeostasis, while reduced ABCG2 expression possibly reflects changes in pathways involved in cellular protection and the handling of potentially harmful compounds. Further longitudinal studies are required to clarify underlying mechanisms and determine their persistence postnatally.

Related

  1. Differential Expression of Salivary microRNA Associated with Keratoconus
    Steve Mabry, Purnima Sharma, Sarah E. Nicholas +3
    Experimental eye researchPeer-reviewedLicence not statedFull textMedical imaging & radiologyPMC
  2. Maternal Vitamin D Deficiency is Associated With Sex‐Dependent Alterations in Neurodevelopment‐Related Gene Expression, Particularly in the Hypothalamus
    Lidia Saidi, Emmanuel Snacel‐Fazy, Eva Seipelt +10
    Molecular Nutrition & Food ResearchPeer-reviewedCC BY 4.0Full textGeneral medicinePMCEurope PMC
  3. Lack of differential sperm acrosome-associated 1 gene expression between X- and Y-bearing spermatozoa in Bali bulls (Bos javanicus domesticus)
    Widjiati Widjiati, Suryo Kuncorojakti, Suherni Susilowati +11
    Veterinary Research ForumPeer-reviewedCC BY-NC-SA 4.0Full textObstetrics, gynaecology & paediatricsPMC
  4. LILRB4 expression is associated with macrophage enrichment and differential survival in hepatocellular carcinoma
    Qi Liu, Yuyang Liu, Junyi Chen +4
    ILIVERPeer-reviewedCC BY-NC-ND 4.0Full textGeneral medicinePMC
  5. Differential Orthopedia Homeobox expression in pulmonary carcinoids is associated with changes in DNA methylation
    Laura Moonen, Lise Mangiante, Daphne J G Leunissen +12
    International Journal of CancerPeer-reviewedCC BY-NC-NDFull text15 citedGeneral biologyOncologyHAL

Cite

BibTeXRIS
BibTeX
@article{vanoyecarlo2026pregestational,
  title = {{Pregestational Body Mass Index Is Associated with Differential Expression of ABC Transporter in the Maternal–Neonatal Dyad}},
  author = {America Vanoye-Carlo and Sandra Berenice Parra-Hernandez and Ameyalli M. Rodríguez-Cano and Otilia Perichart-Perera and Mari Cruz Tolentino-Dolores and Marco Cerbón and Oscar A. Perez-González and Sonia Nava-Salazar},
  journal = {Metabolites},
  year = {2026},
  month = sep,
  doi = {10.3390/metabo16100734},
  url = {https://www.mdpi.com/2218-1989/16/10/734},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Pregestational Body Mass Index Is Associated with Differential Expression of ABC Transporter in the Maternal–Neonatal Dyad
AU  - America Vanoye-Carlo
AU  - Sandra Berenice Parra-Hernandez
AU  - Ameyalli M. Rodríguez-Cano
AU  - Otilia Perichart-Perera
AU  - Mari Cruz Tolentino-Dolores
AU  - Marco Cerbón
AU  - Oscar A. Perez-González
AU  - Sonia Nava-Salazar
PY  - 2026
DA  - 2026/09/30
JO  - Metabolites
DO  - 10.3390/metabo16100734
UR  - https://www.mdpi.com/2218-1989/16/10/734
AB  - Background: Maternal obesity has been associated with fetal growth abnormalities and alterations in metabolic programming. ATP-binding cassette transporters, including ABCA1, ABCG1, ABCC1 and ABCG2, play essential roles in cholesterol homeostasis and placental function, fetal growth and development. However, the regulation of these transporters in the maternal–fetal axis under metabolic stress remains poorly understood. Methods: We evaluated 92 mother–newborn pairs, stratified by pregestational body mass index into three groups: normal weight (n = 34), overweight (n = 35) and obese (n = 23). Metabolic profiles and ABCA1, ABCG1, ABCC1 and ABCG2 mRNA expression in peripheral blood mononuclear cells were assessed. Results: Obese mothers demonstrated significantly higher TyG-BMI indices compared to normal-weight women. Regarding transporter expression, ABCA1 levels were elevated, while ABCG1 and ABCG2 were significantly downregulated in both overweight and obese mothers and their newborns. Positive correlations were observed between maternal and neonatal ABCA1. Maternal metabolic status correlated with ABC transporter expression, as demonstrated by inverse relationships between fasting glucose and maternal ABCA1 expression and between cholesterol levels and maternal ABCG2 expression. Furthermore, ABCG1 and ABCG2 expression levels positively correlated with fetal growth parameters. Conclusions: Maternal overweight and obesity before pregnancy were associated with significant changes in the expression of key ABC transporters in both mothers and their newborns. Changes in maternal ABCA1 and ABCG1 expression could be related to altered cholesterol homeostasis, while reduced ABCG2 expression possibly reflects changes in pathways involved in cellular protection and the handling of potentially harmful compounds. Further longitudinal studies are required to clarify underlying mechanisms and determine their persistence postnatally.
SN  - 2218-1989
ER  -