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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

The Role of Collagen in Coronary Artery Disease

  • Zihan Yang1,2
  • Xianghuan Xie1,2
  • Yuqing Shi1,2
  • Yanghui Chen1,2
  • Guangzhi Chen1,2
  • Yang Sun1,2
  • Renfan Xu3
  1. 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Ave., Wuhan 430030, China
  2. 2Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China
  3. 3Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract

Coronary artery disease (CAD) remains a major cause of morbidity and mortality worldwide, imposing a substantial burden on patients and healthcare systems. Its development and progression are driven not only by lipid accumulation and inflammation but also by extracellular matrix remodeling. Collagen is a core component of the cardiovascular extracellular matrix. Its subtype composition, maturation, cross-linking, synthesis and degradation collectively shape the structural and functional properties of vascular and myocardial tissues. Here, we review collagen biology and use expression profiles from GTEx v11 and Heart Cell Atlas v2 to illustrate tissue- and cell type-specific patterns. These profiles illustrate the expression patterns and major cellular sources of the collagen gene family in the coronary artery and left ventricle. We also evaluate evidence linking collagen-related genetic variation to CAD susceptibility. By connecting genetic variation with protein processing and tissue architecture, this review delineates the potential roles of collagen in plaque stability, coronary thrombosis and post-infarction myocardial remodeling. This framework provides a basis for developing biomarkers of collagen remodeling and mechanism-guided therapeutic strategies.

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Cite

BibTeXRIS
BibTeX
@article{yang2026role,
  title = {{The Role of Collagen in Coronary Artery Disease}},
  author = {Zihan Yang and Xianghuan Xie and Yuqing Shi and Yanghui Chen and Guangzhi Chen and Yang Sun and Renfan Xu},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27219806},
  url = {https://www.mdpi.com/1422-0067/27/21/9806},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - The Role of Collagen in Coronary Artery Disease
AU  - Zihan Yang
AU  - Xianghuan Xie
AU  - Yuqing Shi
AU  - Yanghui Chen
AU  - Guangzhi Chen
AU  - Yang Sun
AU  - Renfan Xu
PY  - 2026
DA  - 2026/10/31
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27219806
UR  - https://www.mdpi.com/1422-0067/27/21/9806
AB  - Coronary artery disease (CAD) remains a major cause of morbidity and mortality worldwide, imposing a substantial burden on patients and healthcare systems. Its development and progression are driven not only by lipid accumulation and inflammation but also by extracellular matrix remodeling. Collagen is a core component of the cardiovascular extracellular matrix. Its subtype composition, maturation, cross-linking, synthesis and degradation collectively shape the structural and functional properties of vascular and myocardial tissues. Here, we review collagen biology and use expression profiles from GTEx v11 and Heart Cell Atlas v2 to illustrate tissue- and cell type-specific patterns. These profiles illustrate the expression patterns and major cellular sources of the collagen gene family in the coronary artery and left ventricle. We also evaluate evidence linking collagen-related genetic variation to CAD susceptibility. By connecting genetic variation with protein processing and tissue architecture, this review delineates the potential roles of collagen in plaque stability, coronary thrombosis and post-infarction myocardial remodeling. This framework provides a basis for developing biomarkers of collagen remodeling and mechanism-guided therapeutic strategies.
SN  - 1422-0067
ER  -