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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Serum Argininosuccinic Acid Is Associated with Diabetes in Patients with Coronary Artery Disease: An Exploratory Targeted LC–MS/MS Study

  • Beata Krasińska1
  • Minseung Kang2
  • Siwon Baek3
  • Dagmara Pietkiewicz4
  • Szymon Plewa5
  • Mariusz Kowalewski6,7,8
  • Giuseppe Maria Raffa7,9
  • Calogera Pisano7,9
  • Piotr Suwalski8
  • Ievgen Spasenenko1
  • Katarzyna Gabriel1
  • Łukasz Stryczyński1
5 more authors
  • Anna Olasińska-Wiśniewska10
  • Jan Matysiak5
  • Zbigniew Krasiński11
  • Andrzej Tykarski1
  • Tomasz Urbanowicz6,7,10
11 affiliations
  1. 1Department of Hypertensiology, Angiology, and Internal Medicine, Poznan University of Medical Sciences, ½ Dluga Street, 61-848 Poznan, Poland.
  2. 2College of Medicine, Korea University, 73 Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
  3. 3College of Medicine, Inje University, 75 Bokji-ro, Busanjin-gu, Busan 47392, Republic of Korea.
  4. 4Centre for Innovative Pharmaceutical Technology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
  5. 5Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 61-614 Poznan, Poland.
  6. 6Thoracic Research Center, Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland.
  7. 7Department of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90134 Palermo, Italy.
  8. 8Department of Cardiac Surgery, Center of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Interior, 02-507 Warszawa, Poland.
  9. 9Department of Research, IRCCS ISMETT, 90127 Palermo, Italy.
  10. 10Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, ½ Długa, 61-848 Poznan, Poland.
  11. 11Department of Vascular, Endovascular Surgery, Angiology and Phlebology, Poznan University of Medical Sciences, ½ Dluga Street, 61-848 Poznan, Poland.
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Abstract

Diabetes mellitus is associated with metabolic alterations, but amino-acid differences among patients with coronary artery disease (CAD) remain incompletely characterized. We screened 45 amino acids and related metabolites by diabetes status in an exploratory retrospective disease-restricted cohort (recorded diseased-vessel count ≥ 1; n = 33). Argininosuccinic acid was available for 26 patients. Comparisons used exact Wilcoxon tests, Cliff’s delta, and Benjamini–Hochberg correction. Estimated argininosuccinic acid concentrations were higher in diabetes (0.28 [0.21–0.34] vs. 0.15 [0.13–0.19] µmol/L; Cliff’s delta = 0.765; p < 0.001; q = 0.035), the only association surviving false-discovery-rate correction. All argininosuccinic acid estimates were extrapolated below the lowest calibrator and should be interpreted as semiquantitative. The diabetes coefficient remained positive in crude and age- and sex-adjusted HC3-robust models, but renal and influence analyses were imprecise. Argininosuccinic acid correlated inversely with eGFR (rho = −0.445; p = 0.023) and positively with creatinine (rho = 0.486; p = 0.012). The diabetes-by-CAD interaction was not significant (p = 0.183). These data suggest a hypothesis-generating association requiring validation with an appropriate calibration range and careful renal phenotyping.

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Cite

BibTeXRIS
BibTeX
@article{krasinska2026serum,
  title = {{Serum Argininosuccinic Acid Is Associated with Diabetes in Patients with Coronary Artery Disease: An Exploratory Targeted LC–MS/MS Study}},
  author = {Beata Krasińska and Minseung Kang and Siwon Baek and Dagmara Pietkiewicz and Szymon Plewa and Mariusz Kowalewski and Giuseppe Maria Raffa and Calogera Pisano and Piotr Suwalski and Ievgen Spasenenko and Katarzyna Gabriel and Łukasz Stryczyński and Anna Olasińska-Wiśniewska and Jan Matysiak and Zbigniew Krasiński and Andrzej Tykarski and Tomasz Urbanowicz},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = sep,
  doi = {10.3390/ijms27198766},
  url = {https://www.mdpi.com/1422-0067/27/19/8766},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Serum Argininosuccinic Acid Is Associated with Diabetes in Patients with Coronary Artery Disease: An Exploratory Targeted LC–MS/MS Study
AU  - Beata Krasińska
AU  - Minseung Kang
AU  - Siwon Baek
AU  - Dagmara Pietkiewicz
AU  - Szymon Plewa
AU  - Mariusz Kowalewski
AU  - Giuseppe Maria Raffa
AU  - Calogera Pisano
AU  - Piotr Suwalski
AU  - Ievgen Spasenenko
AU  - Katarzyna Gabriel
AU  - Łukasz Stryczyński
AU  - Anna Olasińska-Wiśniewska
AU  - Jan Matysiak
AU  - Zbigniew Krasiński
AU  - Andrzej Tykarski
AU  - Tomasz Urbanowicz
PY  - 2026
DA  - 2026/09/30
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27198766
UR  - https://www.mdpi.com/1422-0067/27/19/8766
AB  - Diabetes mellitus is associated with metabolic alterations, but amino-acid differences among patients with coronary artery disease (CAD) remain incompletely characterized. We screened 45 amino acids and related metabolites by diabetes status in an exploratory retrospective disease-restricted cohort (recorded diseased-vessel count ≥ 1; n = 33). Argininosuccinic acid was available for 26 patients. Comparisons used exact Wilcoxon tests, Cliff’s delta, and Benjamini–Hochberg correction. Estimated argininosuccinic acid concentrations were higher in diabetes (0.28 [0.21–0.34] vs. 0.15 [0.13–0.19] µmol/L; Cliff’s delta = 0.765; p < 0.001; q = 0.035), the only association surviving false-discovery-rate correction. All argininosuccinic acid estimates were extrapolated below the lowest calibrator and should be interpreted as semiquantitative. The diabetes coefficient remained positive in crude and age- and sex-adjusted HC3-robust models, but renal and influence analyses were imprecise. Argininosuccinic acid correlated inversely with eGFR (rho = −0.445; p = 0.023) and positively with creatinine (rho = 0.486; p = 0.012). The diabetes-by-CAD interaction was not significant (p = 0.183). These data suggest a hypothesis-generating association requiring validation with an appropriate calibration range and careful renal phenotyping.
SN  - 1422-0067
ER  -