Association of serum uric acid during pre-pregnancy with adverse pregnancy outcomes among women conceived by in-vitro fertilization: a retrospective cohort study.
18 affiliations
- 1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Haidian District, 49 North Garden Rd, Beijing, China.
- 2Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, China.
- 3Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
- 4Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
- 5Department of Medical Engineering, Peking University Third Hospital, Beijing, China.
- 6Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
- 7National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
- 8Key Laboratory of Assisted Reproduction, Ministry of Education, Peking University, Beijing, China.
- 9Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
- 10Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
- 11Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Haidian District, 49 North Garden Rd, Beijing, China. [email protected].
- 12Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, China. [email protected].
- 13Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China. [email protected].
- 14Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China. [email protected].
- 15Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Haidian District, 49 North Garden Rd, Beijing, China. [email protected].
- 16Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, China. [email protected].
- 17Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China. [email protected].
- 18Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China. [email protected].
Abstract
Background
Maternal serum uric acid (UA) levels have been linked to adverse pregnancy outcomes, but no studies have yet examined this association in women undergoing assisted reproductive technology. This study aimed to investigate the relationship between pre-pregnancy UA levels and adverse pregnancy outcomes in women conceived via in vitro fertilization and embryo transfer (IVF-ET).Methods
This retrospective cohort study included 2 111 singleton pregnancies conceived via IVF-ET, delivered at Peking University Third Hospital between 1 January 2017 and 30 April 2022. Restricted cubic splines were used to test nonlinear relationships between serum UA during pre-pregnancy and adverse outcomes, and multivariable logistic regression to calculate odds ratio (OR) and 95% confidence interval (CI).Results
Of the 2 111 women, no significant associations were found between pre-pregnancy UA levels and preeclampsia, preterm birth, or macrosomia. However, a J-shaped relationship was observed for gestational diabetes mellitus (GDM) and low birth weight (LBW), and an inverse U-shaped relationship for gestational hypertension (GH). Reflecting these distinct non-linear topologies, statistically significant peak risks were observed and reported at different strata: women in the higher quintile (4th quintile) of UA had a 3.20-fold increased risk of GH (adjusted OR 3.20, 95% CI 1.23, 8.33) and a 1.38-fold increased risk of GDM (adjusted OR 1.38, 95% CI 1.01, 1.88) compared with the lowest quintile. Conversely, the risk of LBW accelerated sharply and peaked at the highest quintile (5th quintile) (adjusted OR 1.98, 95% CI 1.11, 3.54). In the subgroup analysis, the positive association between pre-pregnancy UA and LBW was more pronounced among patients with day 5 embryo transfer.Conclusions
These findings suggest that optimizing serum UA levels in women planning pregnancy, particularly those undergoing IVF-ET, may have important clinical implications for improving pregnancy outcomes.
Related
- Association Between Pre-pregnancy Obesity and Adverse Obstetric Outcomes: A Retrospective Cohort Study at a Secondary Care Center in Tbilisi, Georgia
- Joint association of preconception fasting plasma glucose and body mass index with adverse pregnancy outcomes: a retrospective cohort study in China
- Association between Ambient Air Pollution Exposure and Reproductive Outcomes following In Vitro Fertilization: A Retrospective Cohort Study
- Association of vitamin E and coenzyme Q10 pretreatment with embryological and pregnancy outcomes in women with diminished ovarian reserve: a retrospective study
- Association of third-trimester maternal lipid levels with adverse pregnancy outcomes in women with gestational diabetes mellitus: a retrospective single-center study using intrapartum data
BibTeX
@article{lan2026association,
title = {{Association of serum uric acid during pre-pregnancy with adverse pregnancy outcomes among women conceived by in-vitro fertilization: a retrospective cohort study.}},
author = {Kexin Lan and Shaohua Yin and Yang Wang and Rong Li and Yangyu Zhao and Yuan Wei and Shaomin Chen and Zhaoping Li},
journal = {Reproductive health},
year = {2026},
month = jul,
doi = {10.1186/s12978-026-02406-w},
url = {https://europepmc.org/article/MED/42902328},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Association of serum uric acid during pre-pregnancy with adverse pregnancy outcomes among women conceived by in-vitro fertilization: a retrospective cohort study.
AU - Kexin Lan
AU - Shaohua Yin
AU - Yang Wang
AU - Rong Li
AU - Yangyu Zhao
AU - Yuan Wei
AU - Shaomin Chen
AU - Zhaoping Li
PY - 2026
DA - 2026/07/01
JO - Reproductive health
DO - 10.1186/s12978-026-02406-w
UR - https://europepmc.org/article/MED/42902328
AB - Background Maternal serum uric acid (UA) levels have been linked to adverse pregnancy outcomes, but no studies have yet examined this association in women undergoing assisted reproductive technology. This study aimed to investigate the relationship between pre-pregnancy UA levels and adverse pregnancy outcomes in women conceived via in vitro fertilization and embryo transfer (IVF-ET).Methods This retrospective cohort study included 2 111 singleton pregnancies conceived via IVF-ET, delivered at Peking University Third Hospital between 1 January 2017 and 30 April 2022. Restricted cubic splines were used to test nonlinear relationships between serum UA during pre-pregnancy and adverse outcomes, and multivariable logistic regression to calculate odds ratio (OR) and 95% confidence interval (CI).Results Of the 2 111 women, no significant associations were found between pre-pregnancy UA levels and preeclampsia, preterm birth, or macrosomia. However, a J-shaped relationship was observed for gestational diabetes mellitus (GDM) and low birth weight (LBW), and an inverse U-shaped relationship for gestational hypertension (GH). Reflecting these distinct non-linear topologies, statistically significant peak risks were observed and reported at different strata: women in the higher quintile (4th quintile) of UA had a 3.20-fold increased risk of GH (adjusted OR 3.20, 95% CI 1.23, 8.33) and a 1.38-fold increased risk of GDM (adjusted OR 1.38, 95% CI 1.01, 1.88) compared with the lowest quintile. Conversely, the risk of LBW accelerated sharply and peaked at the highest quintile (5th quintile) (adjusted OR 1.98, 95% CI 1.11, 3.54). In the subgroup analysis, the positive association between pre-pregnancy UA and LBW was more pronounced among patients with day 5 embryo transfer.Conclusions These findings suggest that optimizing serum UA levels in women planning pregnancy, particularly those undergoing IVF-ET, may have important clinical implications for improving pregnancy outcomes.
SN - 1742-4755
ER -