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Peer-reviewedCC BY 4.0Frontiers in Immunology

Case Report: Cytokine adsorption during multimodal management of hyperinflammatory toxicities following CAR-T in three patients

  • Haoran Xu1
  • Fangce Wang1,2
  • Yuqiu Lu3
  • Wenjun Zhang1,2
  • Yingying Zhang3
  • Aibin Liang1,2
  1. 1Department of Hematology, Shanghai Tongji Hospital, Tongji University School of Medicine
  2. 2Clinical Research Ward of Cancer Center, Shanghai Tongji Hospital, Tongji University School of Medicine
  3. 3Department of Nephrology, Shanghai Tongji Hospital, Tongji University School of Medicine
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Abstract

Chimeric antigen receptor T cell (CAR-T) has advanced rapidly in hematologic malignancies and even solid tumors, but post-treatment adverse reactions remain a major risk. Most adverse reactions are associated with inflammatory responses and cytokine release, such as cytokine release syndrome. Cytokine adsorption is an extracorporeal blood-purification approach designed to adsorb circulating inflammatory mediators. We report three patients with CAR-T-associated CRS, CRS with ICANS, or CRS with IEC-HS who received CA330-based cytokine adsorption as part of multimodal management. Clinical recovery and reductions in selected inflammatory markers were observed during the treatment course, and no procedure-related adverse events were documented. However, because adsorption overlapped with anti-IL-6 therapy, corticosteroids, anti-infective and supportive care, and the natural evolution of these toxicities, its independent contribution could not be determined. These observations support the feasibility of this approach and warrant prospective evaluation.

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Cite

BibTeXRIS
BibTeX
@article{xu2026case,
  title = {{Case Report: Cytokine adsorption during multimodal management of hyperinflammatory toxicities following CAR-T in three patients}},
  author = {Haoran Xu and Fangce Wang and Yuqiu Lu and Wenjun Zhang and Yingying Zhang and Aibin Liang},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1968648},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1968648/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Case Report: Cytokine adsorption during multimodal management of hyperinflammatory toxicities following CAR-T in three patients
AU  - Haoran Xu
AU  - Fangce Wang
AU  - Yuqiu Lu
AU  - Wenjun Zhang
AU  - Yingying Zhang
AU  - Aibin Liang
PY  - 2026
DA  - 2026/10/29
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1968648
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1968648/full
AB  - Chimeric antigen receptor T cell (CAR-T) has advanced rapidly in hematologic malignancies and even solid tumors, but post-treatment adverse reactions remain a major risk. Most adverse reactions are associated with inflammatory responses and cytokine release, such as cytokine release syndrome. Cytokine adsorption is an extracorporeal blood-purification approach designed to adsorb circulating inflammatory mediators. We report three patients with CAR-T-associated CRS, CRS with ICANS, or CRS with IEC-HS who received CA330-based cytokine adsorption as part of multimodal management. Clinical recovery and reductions in selected inflammatory markers were observed during the treatment course, and no procedure-related adverse events were documented. However, because adsorption overlapped with anti-IL-6 therapy, corticosteroids, anti-infective and supportive care, and the natural evolution of these toxicities, its independent contribution could not be determined. These observations support the feasibility of this approach and warrant prospective evaluation.
SN  - 1664-3224
ER  -