Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 20 min ago
Peer-reviewedCC BY 4.0Neuropsychopharmacology

A transient mitochondrial switch underlies long lasting effects of adolescent cannabis

  • Christina Ioannidou
  • Irene Manzanares-Sierra
  • Daniel Jimenez-Blasco
  • Darío García-Rodriguez
  • Israel Manjarrés-Raza
  • Francisca Julio-Kalajzić
  • Antonio C Pagano Zottola
  • Martina Di Bartolomeo
  • Guillaume Ferreira
  • Juan P Bolaños
  • Giovanni Marsicano
  • Arnau Busquets-Garcia
Open at sourcePDFDOICite

Abstract

Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 during adolescence, identifying mitochondrial pathways as causal mechanisms and potential therapeutic targets to reduce their long-term consequences.

Related

  1. The dynamics of gene copy-number mutations: transient changes with long-lasting consequences
    Isabella Tomanek, Călin C Guet
    GeneticsPeer-reviewedCC BY-NC-ND 4.0Full textGenetics & genomicsPMC
  2. Long lasting alterations of feeding by adolescent obesity
    S. Rougeux, D. Mukherjee, R. T. West +2
    bioRxivPreprintCC BY-NC-NDFull textNeurosciencebioRxiv
  3. Longitudinal fMRI reveals altered developmental trajectories of functional network organisation associated with adolescent cannabis use
    E. J. Davies, N. Ertl, T. P. Freeman +8
    bioRxivPreprintCC BY-NC-NDFull textNeurosciencebioRxiv
  4. Life on leaves left a lasting mark on the Methylobacterium core genome
    J.-B. Leducq, D. Sneddon, A. B. Alleman +4
    bioRxivPreprintAll rights reservedFull textEvolutionary biologybioRxiv
  5. Lasting aversive consequences of a single dose of 4-hydroxytamoxifen
    E. J. Kyzar, R. Setara, M. Eisengart +4
    bioRxivPreprintCC BYFull textNeurosciencebioRxiv

Cite

BibTeXRIS
BibTeX
@article{ioannidou2026transient,
  title = {{A transient mitochondrial switch underlies long lasting effects of adolescent cannabis}},
  author = {Christina Ioannidou and Irene Manzanares-Sierra and Daniel Jimenez-Blasco and Darío García-Rodriguez and Israel Manjarrés-Raza and Francisca Julio-Kalajzić and Antonio C Pagano Zottola and Martina Di Bartolomeo and Guillaume Ferreira and Juan P Bolaños and Giovanni Marsicano and Arnau Busquets-Garcia},
  journal = {Neuropsychopharmacology},
  year = {2026},
  month = aug,
  doi = {10.1038/s41386-026-02539-3},
  url = {https://u-bordeaux.hal.science/hal-05745987v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - A transient mitochondrial switch underlies long lasting effects of adolescent cannabis
AU  - Christina Ioannidou
AU  - Irene Manzanares-Sierra
AU  - Daniel Jimenez-Blasco
AU  - Darío García-Rodriguez
AU  - Israel Manjarrés-Raza
AU  - Francisca Julio-Kalajzić
AU  - Antonio C Pagano Zottola
AU  - Martina Di Bartolomeo
AU  - Guillaume Ferreira
AU  - Juan P Bolaños
AU  - Giovanni Marsicano
AU  - Arnau Busquets-Garcia
PY  - 2026
DA  - 2026/08/27
JO  - Neuropsychopharmacology
DO  - 10.1038/s41386-026-02539-3
UR  - https://u-bordeaux.hal.science/hal-05745987v1
AB  - Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 during adolescence, identifying mitochondrial pathways as causal mechanisms and potential therapeutic targets to reduce their long-term consequences.
SN  - 0893-133X
SN  - 0007-0920
ER  -