Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 9 min ago
Peer-reviewedCC BYAnalytical chemistry

Aqueous-Phase Delivery of SLIC-SABRE Hyperpolarized [15N3]Metronidazole.

  • Ivan A Trofimov1
  • Henri de Maissin1,2
  • Obaid Mohiuddin1
  • Josh P Peters3
  • Stefan Sell1
  • Anna Samoilenko4
  • Sebastian Lucas5
  • Jochen Leupold1
  • Maxim Zaitsev1
  • Stephan Knecht5
  • Andrey N Pravdivtsev3
  • Jan-Bernd Hövener3
2 more authors
  • Eduard Y Chekmenev4
  • Andreas B Schmidt1,2,3
5 affiliations
  1. 1Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg79106, Germany.
  2. 2German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership between DKFZ and University Medical Center Freiburg, Im Neuenheimer Feld 280, Heidelberg69120, Germany.
  3. 3Section Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, Kiel24118, Germany.
  4. 4Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan48202, United States.
  5. 5NVision Imaging Technologies GmbH, Ulm89081, Germany.
Read full textPDFDOICite

Abstract

Metronidazole is an antiprotozoal antibiotic drug holding promise for tumor microenvironment analysis in hyperpolarized MRI due to its hypoxia-sensitive metabolism. Previous studies have explored the 15N hyperpolarization of metronidazole using dissolution dynamic nuclear polarization (d-DNP) and signal amplification by reversible exchange (SABRE). Here, we demonstrate that by using spin-lock-induced crossing (SLIC), 15N polarization levels up to 10-11% are achieved for 30 mM [15N3]metronidazole, improving polarization levels by a factor of 1.4 ± 0.1 compared to polarization levels achieved in conventional SABRE experiments under otherwise the same conditions. This polarization was harnessed to probe the purification of methanolic solutions of hyperpolarized [15N3]metronidazole, reducing the methanol concentration by 10-fold in the obtained aqueous solutions of 15N-hyperpolarized metronidazole, retaining up to 1/3 of initial polarization. This pilot study marks a substantial step toward the biomedical application of [15N3]metronidazole and is promising for the 15N-hyperpolarization of other substrates via SLIC and other SABRE strategies.

Related

  1. Aqueous Phase Reforming of Model HTL Wastewater with Pt/C and Ru/C Catalysts
    Gasser Saleh, Samuel Duplessis, William Cook +1
    ChemRxivPreprintLicence not statedGeneral chemistryChemRxiv
  2. γ-Ray Driven Aqueous-Phase Methane Conversions into Complex Molecules up to Glycine
    F. Fang, X. Sun, Y. Liu +4
    Angewandte Chemie International EditionPeer-reviewedLicence not statedFull text3 citedOrganic chemistryHAL
  3. Neutral-pH pNZ Removal Enables Fully Aqueous Solid-Phase Synthesis of Linear and ε-Lys-Branched Peptides
    Jan Pawlas, Linnea Wahlqvist, Olov Nilsson +1
    ACS OmegaPeer-reviewedCC BY-NC-ND 4.0Full textGeneral chemistryCrossref
  4. Aqueous-phase Synthesis of MIL-88B(Fe) and Crystal Size Control via Three-Phase W/O Emulsions
    Masashi Takahashi, Yuma Uehara, Ai Takenouchi +5
    Journal of Oleo SciencePeer-reviewedCC BYFull textInorganic & organometallic chemistryJ-STAGE
  5. Anomalous correlations between ionic conductivity isotherms and phase diagrams in hydrofluoric and acetic acid aqueous systems
    Hilal Al-Salih, Asefeh Poshtchioskuei, Yaser Abu-Lebdeh
    RSC advancesPeer-reviewedCC BY-NCFull textGeneral chemistryEurope PMCPMC

Cite

BibTeXRIS
BibTeX
@article{trofimov2026aqueousphase,
  title = {{Aqueous-Phase Delivery of SLIC-SABRE Hyperpolarized [15N3]Metronidazole.}},
  author = {Ivan A Trofimov and Henri de Maissin and Obaid Mohiuddin and Josh P Peters and Stefan Sell and Anna Samoilenko and Sebastian Lucas and Jochen Leupold and Maxim Zaitsev and Stephan Knecht and Andrey N Pravdivtsev and Jan-Bernd Hövener and Eduard Y Chekmenev and Andreas B Schmidt},
  journal = {Analytical chemistry},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.analchem.6c01373},
  url = {https://europepmc.org/article/MED/42915672},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Aqueous-Phase Delivery of SLIC-SABRE Hyperpolarized [15N3]Metronidazole.
AU  - Ivan A Trofimov
AU  - Henri de Maissin
AU  - Obaid Mohiuddin
AU  - Josh P Peters
AU  - Stefan Sell
AU  - Anna Samoilenko
AU  - Sebastian Lucas
AU  - Jochen Leupold
AU  - Maxim Zaitsev
AU  - Stephan Knecht
AU  - Andrey N Pravdivtsev
AU  - Jan-Bernd Hövener
AU  - Eduard Y Chekmenev
AU  - Andreas B Schmidt
PY  - 2026
DA  - 2026/10/01
JO  - Analytical chemistry
DO  - 10.1021/acs.analchem.6c01373
UR  - https://europepmc.org/article/MED/42915672
AB  - Metronidazole is an antiprotozoal antibiotic drug holding promise for tumor microenvironment analysis in hyperpolarized MRI due to its hypoxia-sensitive metabolism. Previous studies have explored the 15N hyperpolarization of metronidazole using dissolution dynamic nuclear polarization (d-DNP) and signal amplification by reversible exchange (SABRE). Here, we demonstrate that by using spin-lock-induced crossing (SLIC), 15N polarization levels up to 10-11% are achieved for 30 mM [15N3]metronidazole, improving polarization levels by a factor of 1.4 ± 0.1 compared to polarization levels achieved in conventional SABRE experiments under otherwise the same conditions. This polarization was harnessed to probe the purification of methanolic solutions of hyperpolarized [15N3]metronidazole, reducing the methanol concentration by 10-fold in the obtained aqueous solutions of 15N-hyperpolarized metronidazole, retaining up to 1/3 of initial polarization. This pilot study marks a substantial step toward the biomedical application of [15N3]metronidazole and is promising for the 15N-hyperpolarization of other substrates via SLIC and other SABRE strategies.
SN  - 0003-2700
SN  - 1520-6882
ER  -