Comparison of heart rate variability in normotensive and newly detected hypertensive adults in a tertiary care hospital, Mysuru, Karnataka.
- 1Department of Community Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.
- 2Department of Physiology, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.
Abstract
Background and objectives Autonomic dysfunction plays a key role in blood pressure regulation, and heart rate variability (HRV) is a sensitive non-invasive marker of autonomic function. This study aimed to compare HRV among newly detected hypertensive and normotensive adults and to examine the association of HRV parameters with blood pressure levels. Methods This hospital-based case-control study included 52 participants (26 hypertensives and 26 normotensives). Time-domain HRV parameters, standard deviation of all normal-to-normal RR intervals (SDNN), and root mean square of successive differences (RMSSD) and frequency-domain parameters, low frequency (LF), high frequency (HF), and LF/HF ratio, were derived from electrocardiographic recordings. HRV parameters were compared between normotensive and hypertensive groups. Correlation with blood pressure and LF/HF was assessed using Spearman's correlation, and logistic regression was used to examine the independent association between HRV and blood pressure parameters. Significance was set at 5% (P< 0.05). Results Time-domain measures of HRV among hypertensives had lower SDNN [28.16 (21.75-39.50) ms2, P=0.020], and lower RMSSD [16.88 (11.79-25.51) ms2, P=0.003]. In the frequency domain, hypertensive individuals showed significantly lower HF [102.25 (53.73-209.75), P<0.001], and the LF/HF ratio was significantly higher [1.94 (1.60-3.19), P< 0.001]. LF/HF ratio correlated positively with systolic (rₛ=0.49) and diastolic blood pressure (rₛ= 0.50), both P<0.001. Multinomial logistic regression shows that higher systolic blood pressure was significantly associated with increased odds of sympathetic dominance [Odds ratio (OR) 1.09, 95% Confidence interval (CI) (1.04-1.15), P<0.001]. Interpretation and conclusions Newly detected hypertensive adults demonstrated reduced parasympathetic activity and increased sympathetic dominance, with the LF/HF ratio showing a significant positive association with systolic and diastolic blood pressure and independently predicted hypertension.
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BibTeX
@article{gopinath2026comparison,
title = {{Comparison of heart rate variability in normotensive and newly detected hypertensive adults in a tertiary care hospital, Mysuru, Karnataka.}},
author = {Vishnupriya Gopinath and Yashashwini Anethyar and Madhu Basavegowda and Vijaya Vageesh and Mounika Sree Manivasagan and Chaithra Mallaiah and Uday Babu J and Vitta Shanmukha Srinivas},
journal = {The Indian journal of medical research},
year = {2026},
month = aug,
doi = {10.25259/ijmr_697_2026},
url = {https://europepmc.org/article/MED/42851235},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Comparison of heart rate variability in normotensive and newly detected hypertensive adults in a tertiary care hospital, Mysuru, Karnataka.
AU - Vishnupriya Gopinath
AU - Yashashwini Anethyar
AU - Madhu Basavegowda
AU - Vijaya Vageesh
AU - Mounika Sree Manivasagan
AU - Chaithra Mallaiah
AU - Uday Babu J
AU - Vitta Shanmukha Srinivas
PY - 2026
DA - 2026/08/01
JO - The Indian journal of medical research
DO - 10.25259/ijmr_697_2026
UR - https://europepmc.org/article/MED/42851235
AB - Background and objectives Autonomic dysfunction plays a key role in blood pressure regulation, and heart rate variability (HRV) is a sensitive non-invasive marker of autonomic function. This study aimed to compare HRV among newly detected hypertensive and normotensive adults and to examine the association of HRV parameters with blood pressure levels. Methods This hospital-based case-control study included 52 participants (26 hypertensives and 26 normotensives). Time-domain HRV parameters, standard deviation of all normal-to-normal RR intervals (SDNN), and root mean square of successive differences (RMSSD) and frequency-domain parameters, low frequency (LF), high frequency (HF), and LF/HF ratio, were derived from electrocardiographic recordings. HRV parameters were compared between normotensive and hypertensive groups. Correlation with blood pressure and LF/HF was assessed using Spearman's correlation, and logistic regression was used to examine the independent association between HRV and blood pressure parameters. Significance was set at 5% (P< 0.05). Results Time-domain measures of HRV among hypertensives had lower SDNN [28.16 (21.75-39.50) ms2, P=0.020], and lower RMSSD [16.88 (11.79-25.51) ms2, P=0.003]. In the frequency domain, hypertensive individuals showed significantly lower HF [102.25 (53.73-209.75), P<0.001], and the LF/HF ratio was significantly higher [1.94 (1.60-3.19), P< 0.001]. LF/HF ratio correlated positively with systolic (rₛ=0.49) and diastolic blood pressure (rₛ= 0.50), both P<0.001. Multinomial logistic regression shows that higher systolic blood pressure was significantly associated with increased odds of sympathetic dominance [Odds ratio (OR) 1.09, 95% Confidence interval (CI) (1.04-1.15), P<0.001]. Interpretation and conclusions Newly detected hypertensive adults demonstrated reduced parasympathetic activity and increased sympathetic dominance, with the LF/HF ratio showing a significant positive association with systolic and diastolic blood pressure and independently predicted hypertension.
SN - 0971-5916
ER -