Peer-reviewedCC BY-NC-ND 4.0Journal of Applied Physiology
Breath-by-breath parasternal intercostal muscle stiffening tracks inspiratory effort during graded inspiratory threshold loading in humans
Abstract
Using ultrasound shear wave elastography, we tracked parasternal intercostal muscle stiffness breath-by-breath during quiet breathing and graded inspiratory threshold loading. Changes in parasternal intercostal muscle stiffness increased progressively with load and were closely associated with indices of inspiratory effort from pressure recordings and diaphragm electrical activity. Stiffness measurements identified breaths with elevated inspiratory effort and may serve as a practical, noninvasive mechanical readout of global inspiratory effort, with potential relevance for respiratory disease assessment and assisted-ventilation monitoring.
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BibTeX
@article{nierding2026breathbybreath,
title = {{Breath-by-breath parasternal intercostal muscle stiffening tracks inspiratory effort during graded inspiratory threshold loading in humans}},
author = {Axel Nierding and Eloïse Chamalet and Thomas Similowski and Jean-Luc Gennisson and Damien Bachasson},
journal = {Journal of Applied Physiology},
year = {2026},
month = jun,
doi = {10.1152/japplphysiol.00160.2026},
url = {https://hal.science/hal-05792963v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Breath-by-breath parasternal intercostal muscle stiffening tracks inspiratory effort during graded inspiratory threshold loading in humans
AU - Axel Nierding
AU - Eloïse Chamalet
AU - Thomas Similowski
AU - Jean-Luc Gennisson
AU - Damien Bachasson
PY - 2026
DA - 2026/06/01
JO - Journal of Applied Physiology
DO - 10.1152/japplphysiol.00160.2026
UR - https://hal.science/hal-05792963v1
AB - Using ultrasound shear wave elastography, we tracked parasternal intercostal muscle stiffness breath-by-breath during quiet breathing and graded inspiratory threshold loading. Changes in parasternal intercostal muscle stiffness increased progressively with load and were closely associated with indices of inspiratory effort from pressure recordings and diaphragm electrical activity. Stiffness measurements identified breaths with elevated inspiratory effort and may serve as a practical, noninvasive mechanical readout of global inspiratory effort, with potential relevance for respiratory disease assessment and assisted-ventilation monitoring.
SN - 8750-7587
SN - 1522-1601
ER -