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Peer-reviewedCC BY-NC 4.0Clinical Psychopharmacology and Neuroscience

Preliminary Investigation of Maternal and Offspring Genetic Effects of the DBH Gene in Probands with Schizophrenia and Their Relatives

  • Seulchan Kwak1,2
  • Byung Dae Lee1,2,3
  • Young Min Lee1,2,3
  • Eunsoo Moon1,2,3
  • Hwagyu Suh1,2
  • Kyungwon Kim1,2
  • Siyul Kim1,2
  1. 1Department of Psychiatry, Pusan National University Hospital, Busan, Korea
  2. 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
  3. 3Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea
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Abstract

Objective: This pilot study aimed to investigate maternal and offspring genetic effects of the dopamine beta-hydroxylase (DBH) gene in schizophrenia by applying estimation of maternal, imprinting and interaction effects using multinomial modeling (EMIM) to Korean families.

Methods: We recruited 27 probands with schizophrenia, along with their parents and siblings whenever available. Three single nucleotide polymorphisms (SNPs) in the DBH gene on chromosome 9q34 were analyzed using EMIM to evaluate maternal and offspring genetic effects.

Results: Among the three SNPs analyzed, rs5320 showed a significant maternal genetic effect after adjustment for child genetic effects (p = 0.0086), which remained significant after Bonferroni correction. A nominally significant child genetic effect after adjustment for maternal genetic effects was also observed (p = 0.0457).

Conclusion: This pilot study suggests a potential maternal genetic effect of DBH rs5320 in schizophrenia. However, these preliminary findings require validation in larger and more complete family-based samples.

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Cite

BibTeXRIS
BibTeX
@article{kwak2026preliminary,
  title = {{Preliminary Investigation of Maternal and Offspring Genetic Effects of the DBH Gene in Probands with Schizophrenia and Their Relatives}},
  author = {Seulchan Kwak and Byung Dae Lee and Young Min Lee and Eunsoo Moon and Hwagyu Suh and Kyungwon Kim and Siyul Kim},
  journal = {Clinical Psychopharmacology and Neuroscience},
  year = {2026},
  month = aug,
  doi = {10.9758/cpn.26.1454},
  url = {https://doi.org/10.9758/cpn.26.1454},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Preliminary Investigation of Maternal and Offspring Genetic Effects of the DBH Gene in Probands with Schizophrenia and Their Relatives
AU  - Seulchan Kwak
AU  - Byung Dae Lee
AU  - Young Min Lee
AU  - Eunsoo Moon
AU  - Hwagyu Suh
AU  - Kyungwon Kim
AU  - Siyul Kim
PY  - 2026
DA  - 2026/08/26
JO  - Clinical Psychopharmacology and Neuroscience
DO  - 10.9758/cpn.26.1454
UR  - https://doi.org/10.9758/cpn.26.1454
AB  - Objective: This pilot study aimed to investigate maternal and offspring genetic effects of the dopamine beta-hydroxylase (DBH) gene in schizophrenia by applying estimation of maternal, imprinting and interaction effects using multinomial modeling (EMIM) to Korean families.  Methods: We recruited 27 probands with schizophrenia, along with their parents and siblings whenever available. Three single nucleotide polymorphisms (SNPs) in the DBH gene on chromosome 9q34 were analyzed using EMIM to evaluate maternal and offspring genetic effects.  Results: Among the three SNPs analyzed, rs5320 showed a significant maternal genetic effect after adjustment for child genetic effects (p = 0.0086), which remained significant after Bonferroni correction. A nominally significant child genetic effect after adjustment for maternal genetic effects was also observed (p = 0.0457).  Conclusion: This pilot study suggests a potential maternal genetic effect of DBH rs5320 in schizophrenia. However, these preliminary findings require validation in larger and more complete family-based samples.
SN  - 1738-1088
SN  - 2093-4327
ER  -