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Peer-reviewedCC BY 4.0Respirology Case Reports

Complete Surgical Resection of Rare Solitary Anterior Mediastinal Metastasis From Ovarian Clear Cell Carcinoma

  • Teruhisa Chiba1
  • Kaito Yano1
  • Tomohiro Imoto1
  • Mikito Suzuki1
  • Reiko Shimizu1
  • Tsunekazu Hishima2
  • Kazuo Nakagawa1
  1. 1Department of Thoracic Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan
  2. 2Department of Pathology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan
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Abstract

Epithelial ovarian cancer typically spreads via transcoelomic dissemination and lymphatic pathways. Extra‐abdominal metastases presenting as solitary anterior mediastinal lesions are rare. Ovarian clear cell carcinoma (CCC) is characterized by aggressive local behaviour but has a lower propensity for distant metastasis than serous carcinoma. Furthermore, it is less sensitive to platinum‐based chemotherapy than other epithelial ovarian cancers. Here, we report a rare case of ovarian CCC with a solitary anterior mediastinal metastasis after primary surgery. A woman in her 50s had a 2.6‐cm anterior mediastinal mass during postoperative surveillance. Considering progressive lesion enlargement and increased 18F‐fluorodeoxyglucose uptake on positron emission tomography‐computed tomography, complete surgical resection via median sternotomy was performed. Histopathological and immunohistochemical findings confirmed the presence of metastatic ovarian CCC. The patient remained disease‐free for 6 months postoperatively. Complete surgical resection may represent an effective treatment option for isolated recurrence of chemoresistant histological subtypes.

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Cite

BibTeXRIS
BibTeX
@article{chiba2026complete,
  title = {{Complete Surgical Resection of Rare Solitary Anterior Mediastinal Metastasis From Ovarian Clear Cell Carcinoma}},
  author = {Teruhisa Chiba and Kaito Yano and Tomohiro Imoto and Mikito Suzuki and Reiko Shimizu and Tsunekazu Hishima and Kazuo Nakagawa},
  journal = {Respirology Case Reports},
  year = {2026},
  month = nov,
  doi = {10.1002/rcr2.70809},
  url = {https://doi.org/10.1002/rcr2.70809},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Complete Surgical Resection of Rare Solitary Anterior Mediastinal Metastasis From Ovarian Clear Cell Carcinoma
AU  - Teruhisa Chiba
AU  - Kaito Yano
AU  - Tomohiro Imoto
AU  - Mikito Suzuki
AU  - Reiko Shimizu
AU  - Tsunekazu Hishima
AU  - Kazuo Nakagawa
PY  - 2026
DA  - 2026/11/03
JO  - Respirology Case Reports
DO  - 10.1002/rcr2.70809
UR  - https://doi.org/10.1002/rcr2.70809
AB  - Epithelial ovarian cancer typically spreads via transcoelomic dissemination and lymphatic pathways. Extra‐abdominal metastases presenting as solitary anterior mediastinal lesions are rare. Ovarian clear cell carcinoma (CCC) is characterized by aggressive local behaviour but has a lower propensity for distant metastasis than serous carcinoma. Furthermore, it is less sensitive to platinum‐based chemotherapy than other epithelial ovarian cancers. Here, we report a rare case of ovarian CCC with a solitary anterior mediastinal metastasis after primary surgery. A woman in her 50s had a 2.6‐cm anterior mediastinal mass during postoperative surveillance. Considering progressive lesion enlargement and increased 18F‐fluorodeoxyglucose uptake on positron emission tomography‐computed tomography, complete surgical resection via median sternotomy was performed. Histopathological and immunohistochemical findings confirmed the presence of metastatic ovarian CCC. The patient remained disease‐free for 6 months postoperatively. Complete surgical resection may represent an effective treatment option for isolated recurrence of chemoresistant histological subtypes.
SN  - 2051-3380
ER  -