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Peer-reviewedCC BY-NC-NDDiscover nano

Optimization of copper and tin disulfide based surface plasmon resonance for the detection of brain tumor tissues.

  • Rajeev Kumar1
  • Biswajit Brahma2
  • Lalit Garia3
  • Manoj Kumar4
  • Akash Kumar Bhoi5
5 affiliations
  1. 1Department of Electronics and Communication, Graphic Era (Deemed to be University), Engineering, Dehradun, 248001, Uttarakhand, India.
  2. 2McKesson Corporation, 32559 Lake Bridgeport St, Fremont, CA, 94555, USA.
  3. 3Department Electronics and Communication Engineering, Bipin Tripathi Kumaon Institute of Technology, Dwarahat, 263653, Uttarakhand, India. [email protected].
  4. 4Department of Electronics & Communication Engineering, G. B. Pant Institute of Engineering and Technology, Pauri, Uttarakhand, 246194, India.
  5. 5Symbiosis Institute of Technology, Pune Campus, Symbiosis International (Deemed University), 412115, Pune, India. [email protected].
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Abstract

In this study, a surface plasmon resonance (SPR) sensor, including SF5 prism, copper (Cu), Tin Disulfide (SnS₂), Molybdenum Ditelluride (MoTe₂), and sensing medium (SM) layers, was designed for the detection of brain lesions. With the remarkable sensitivity of 142.15°/RIU found at 33 nm of Cu, 8 nm of SnS₂, a monolayer of MoTe2, and refractive index (RI) of SM 1.33-1.50. To obtain the sensitivity of the proposed sensor, different brain lesions, including cerebrospinal fluid (CSF), gray matter, oligodendroglioma, low-grade glioma, lymphoma, and metastasis, were used as SM, while the thickness of the Cu layer was varied from 25 to 60 nm. A sharp SPR dip with a minimum reflectance (Rmin) of 3.9 × 10⁻⁷ a.u. was obtained at a thickness of 33 nm, which also yielded the highest sensitivity (S = 136.47°/RIU) and figure of merit (FoM = 15.01/RIU). The low full width at half maximum (FWHM) at this thickness and the SPR angle shift (Δθres) further confirmed the improved detection capability of the sensor. According to these results, the proposed SPR sensor is very useful for detecting brain abnormalities in real time and without labels.

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Cite

BibTeXRIS
BibTeX
@article{kumar2026optimization,
  title = {{Optimization of copper and tin disulfide based surface plasmon resonance for the detection of brain tumor tissues.}},
  author = {Rajeev Kumar and Biswajit Brahma and Lalit Garia and Manoj Kumar and Akash Kumar Bhoi},
  journal = {Discover nano},
  year = {2026},
  month = oct,
  doi = {10.1186/s11671-026-04899-7},
  url = {https://europepmc.org/article/MED/42911311},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Optimization of copper and tin disulfide based surface plasmon resonance for the detection of brain tumor tissues.
AU  - Rajeev Kumar
AU  - Biswajit Brahma
AU  - Lalit Garia
AU  - Manoj Kumar
AU  - Akash Kumar Bhoi
PY  - 2026
DA  - 2026/10/22
JO  - Discover nano
DO  - 10.1186/s11671-026-04899-7
UR  - https://europepmc.org/article/MED/42911311
AB  - In this study, a surface plasmon resonance (SPR) sensor, including SF5 prism, copper (Cu), Tin Disulfide (SnS₂), Molybdenum Ditelluride (MoTe₂), and sensing medium (SM) layers, was designed for the detection of brain lesions. With the remarkable sensitivity of 142.15°/RIU found at 33 nm of Cu, 8 nm of SnS₂, a monolayer of MoTe2, and refractive index (RI) of SM 1.33-1.50. To obtain the sensitivity of the proposed sensor, different brain lesions, including cerebrospinal fluid (CSF), gray matter, oligodendroglioma, low-grade glioma, lymphoma, and metastasis, were used as SM, while the thickness of the Cu layer was varied from 25 to 60 nm. A sharp SPR dip with a minimum reflectance (Rmin) of 3.9 × 10⁻⁷ a.u. was obtained at a thickness of 33 nm, which also yielded the highest sensitivity (S = 136.47°/RIU) and figure of merit (FoM = 15.01/RIU). The low full width at half maximum (FWHM) at this thickness and the SPR angle shift (Δθres) further confirmed the improved detection capability of the sensor. According to these results, the proposed SPR sensor is very useful for detecting brain abnormalities in real time and without labels.
SN  - 2731-9229
ER  -