The Critically Endangered Bolivian Endemic Hieronymiella bedelarii (Amaryllidaceae): First Alkaloid Profile, Cholinesterase Inhibition, and Ex Situ Conservation Insights.
4 affiliations
- 1Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), CCT CONICET San Juan, Av. Libertador General San Martín 1109 (O), San Juan 5400, Argentina.
- 2Instituto de Biotecnología, Facultad de Ingeniería, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 (O), San Juan 5400, Argentina.
- 3Escuela Profesional de Ingeniería Agroindustrial, Universidad Nacional de Moquegua, Prolongación Calle Ancash s/n, Moquegua 18001, Peru.
- 4Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.
Abstract
Hieronymiella bedelarii is a Bolivian endemic species known from a single locality in Torotoro National Park and currently assessed as Critically Endangered on the IUCN Red List. Its alkaloid composition and cholinesterase-inhibitory activity have not previously been investigated. The GC-MS analysis identified eighteen alkaloids representing six structural types, with lycorine-, pretazettine- and homolycorine-type alkaloids being the most abundant groups. Bulbs of H. bedelarii yielded an alkaloid-enriched extract (0.80% w/w). Eight of the identified alkaloids are reported here for the first time in Hieronymiella, including candimine. Complementary UPLC-MS/MS analysis detected pretazettine and the artifact tazettine in the alkaloid-enriched extract. This extract showed stronger inhibition of acetylcholinesterase than butyrylcholinesterase, with IC₅₀ values of 10.18 and 193.19 µg·mL⁻¹, respectively. In a preliminary cultivation trial, 11 of 20 bulbils (55%) established and developed roots and leaves after 12 months under nursery conditions.
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BibTeX
@article{llallacordova2026critically,
title = {{The Critically Endangered Bolivian Endemic Hieronymiella bedelarii (Amaryllidaceae): First Alkaloid Profile, Cholinesterase Inhibition, and Ex Situ Conservation Insights.}},
author = {Olimpia Llalla-Córdova and Javier E Ortiz and Luciana R Tallini and Victoria Parera and Laura Torras-Claveria and Lorena C Luna and Gabriela E Feresin},
journal = {Plants (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/plants15203125},
url = {https://europepmc.org/article/MED/42943079},
note = {CC BY},
}
RIS
TY - JOUR
TI - The Critically Endangered Bolivian Endemic Hieronymiella bedelarii (Amaryllidaceae): First Alkaloid Profile, Cholinesterase Inhibition, and Ex Situ Conservation Insights.
AU - Olimpia Llalla-Córdova
AU - Javier E Ortiz
AU - Luciana R Tallini
AU - Victoria Parera
AU - Laura Torras-Claveria
AU - Lorena C Luna
AU - Gabriela E Feresin
PY - 2026
DA - 2026/10/13
JO - Plants (Basel, Switzerland)
DO - 10.3390/plants15203125
UR - https://europepmc.org/article/MED/42943079
AB - Hieronymiella bedelarii is a Bolivian endemic species known from a single locality in Torotoro National Park and currently assessed as Critically Endangered on the IUCN Red List. Its alkaloid composition and cholinesterase-inhibitory activity have not previously been investigated. The GC-MS analysis identified eighteen alkaloids representing six structural types, with lycorine-, pretazettine- and homolycorine-type alkaloids being the most abundant groups. Bulbs of H. bedelarii yielded an alkaloid-enriched extract (0.80% w/w). Eight of the identified alkaloids are reported here for the first time in Hieronymiella, including candimine. Complementary UPLC-MS/MS analysis detected pretazettine and the artifact tazettine in the alkaloid-enriched extract. This extract showed stronger inhibition of acetylcholinesterase than butyrylcholinesterase, with IC₅₀ values of 10.18 and 193.19 µg·mL⁻¹, respectively. In a preliminary cultivation trial, 11 of 20 bulbils (55%) established and developed roots and leaves after 12 months under nursery conditions.
SN - 2223-7747
ER -