Comparison of intraoperative hemodynamic changes and recovery outcomes between non-menopausal and postmenopausal women undergoing total abdominal hysterectomy under general anesthesia.
6 affiliations
- 1Department of Anesthesiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
- 2Department of Gynecology and Obstetrics, Alborz University of Medical Sciences, Karaj, Iran.
- 3Department of Management and Psychiatric Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- 4Department of Anesthesiology, School of Allied Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran.
- 5Anesthesia Technology Department, Faculty of Paramedicine, Alborz University of Medical Sciences, Karaj, Iran.
- 6Department of Anesthesiology, School of Allied Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran. [email protected].
Abstract
Background
Menopausal status may influence autonomic and hemodynamic responses during surgery because of hormonal changes affecting vascular tone and thermoregulation. However, evidence comparing perioperative physiological responses and post-anesthesia care unit outcomes between non-menopausal and postmenopausal women undergoing total abdominal hysterectomy remains limited. This study compared perioperative hemodynamic changes and early postoperative recovery between these two populations.Methods
In this prospective observational study, 48 women (25 non-menopausal and 23 postmenopausal) undergoing elective total abdominal hysterectomy under standardized general anesthesia were enrolled. Intraoperative and recovery physiologic parameters, postoperative shivering, pain, nausea and vomiting, agitation, and consciousness were assessed and compared between groups using appropriate statistical analyses.Results
Non-menopausal women demonstrated significantly higher postoperative HR, higher incidence of postoperative shivering, and lower body temperature than postmenopausal women (both P < 0.05). In contrast, MAP was significantly higher in postmenopausal patients throughout the perioperative period (P = 0.001), although no significant time-by-group interaction was observed. HR and temperature showed a significant interaction between time and menopausal status (P = 0.001). No significant between-group differences were found in postoperative pain, nausea and vomiting, agitation, oxygen saturation, level of consciousness, or recovery time (all P > 0.05).Conclusion
Menopausal status was associated with differences in postoperative heart rate and thermoregulatory responses during recovery after total abdominal hysterectomy under general anesthesia, while overall early recovery outcomes remained comparable between groups.
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BibTeX
@article{mashak2026comparison,
title = {{Comparison of intraoperative hemodynamic changes and recovery outcomes between non-menopausal and postmenopausal women undergoing total abdominal hysterectomy under general anesthesia.}},
author = {Banafsheh Mashak and Samira Abdollahi and Hananeh Habib and Fatemeh Nematian and Fateme Javaheri and Reza Payami and Maryam Sarkhosh},
journal = {BMC anesthesiology},
year = {2026},
month = aug,
doi = {10.1186/s12871-026-04153-8},
url = {https://europepmc.org/article/MED/42968006},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Comparison of intraoperative hemodynamic changes and recovery outcomes between non-menopausal and postmenopausal women undergoing total abdominal hysterectomy under general anesthesia.
AU - Banafsheh Mashak
AU - Samira Abdollahi
AU - Hananeh Habib
AU - Fatemeh Nematian
AU - Fateme Javaheri
AU - Reza Payami
AU - Maryam Sarkhosh
PY - 2026
DA - 2026/08/05
JO - BMC anesthesiology
DO - 10.1186/s12871-026-04153-8
UR - https://europepmc.org/article/MED/42968006
AB - Background Menopausal status may influence autonomic and hemodynamic responses during surgery because of hormonal changes affecting vascular tone and thermoregulation. However, evidence comparing perioperative physiological responses and post-anesthesia care unit outcomes between non-menopausal and postmenopausal women undergoing total abdominal hysterectomy remains limited. This study compared perioperative hemodynamic changes and early postoperative recovery between these two populations.Methods In this prospective observational study, 48 women (25 non-menopausal and 23 postmenopausal) undergoing elective total abdominal hysterectomy under standardized general anesthesia were enrolled. Intraoperative and recovery physiologic parameters, postoperative shivering, pain, nausea and vomiting, agitation, and consciousness were assessed and compared between groups using appropriate statistical analyses.Results Non-menopausal women demonstrated significantly higher postoperative HR, higher incidence of postoperative shivering, and lower body temperature than postmenopausal women (both P < 0.05). In contrast, MAP was significantly higher in postmenopausal patients throughout the perioperative period (P = 0.001), although no significant time-by-group interaction was observed. HR and temperature showed a significant interaction between time and menopausal status (P = 0.001). No significant between-group differences were found in postoperative pain, nausea and vomiting, agitation, oxygen saturation, level of consciousness, or recovery time (all P > 0.05).Conclusion Menopausal status was associated with differences in postoperative heart rate and thermoregulatory responses during recovery after total abdominal hysterectomy under general anesthesia, while overall early recovery outcomes remained comparable between groups.
SN - 1471-2253
ER -