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Peer-reviewedCC BYMinia Journal of Medical Research

Intraoperative hemodynamic changes in patients receiving dexmedetomidine for general anesthesia.

  • Arwa Anwar1
  • Tarek Abdelzaher2
  • amr nady3
  • Ibrahim Talaat4
4 affiliations
  1. 1Anesthesiology, Intensive Care and Pain managment Department, Faculty of Medicine. Minia University, Minia, Egypt
  2. 2Anesthesia and intensive care faculty of medicine Minia university Minia Egypt
  3. 3anesthesia,Medicine, Minia University
  4. 4Anesthesia and ICU department, Minia University
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Abstract

Background

Dexmedetomidine is a selective alpha-2 adrenergic agonist used primarily for intravenous sedation in intensive care units and during surgical or diagnostic procedures.

Methods

This prospective randomized study was carried out on 90 adult patients aged 65 years and older who presented to the operating room for surgery under general anesthesia. Patients were divided into two equal groups. Group (A) received general anesthesia after infusion of normal saline, while group (B) received general anesthesia after a loading dose of dexmedetomidine 0.6 µg/kg.

Results

There was a statistically significant decrease in hemodynamic parameters observed in the two groups after induction of anesthesia. Dexmedetomidine administration resulted in a further significant decrease in these parameters when compared to the control group. These changes were not clinically significant, as the values remained within normal ranges. This effect may be beneficial in elderly patients undergoing surgery under general anesthesia.

Conclusion

Dexmedetomidine provided superior hemodynamic stability compared with the control group.

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Cite

BibTeXRIS
BibTeX
@article{anwar2026intraoperative,
  title = {{Intraoperative hemodynamic changes in patients receiving dexmedetomidine for general anesthesia.}},
  author = {Arwa Anwar and Tarek Abdelzaher and amr nady and Ibrahim Talaat},
  journal = {Minia Journal of Medical Research},
  year = {2026},
  month = oct,
  doi = {10.21608/mjmr.2026.537579.2408},
  url = {https://doi.org/10.21608/mjmr.2026.537579.2408},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Intraoperative hemodynamic changes in patients receiving dexmedetomidine for general anesthesia.
AU  - Arwa Anwar
AU  - Tarek Abdelzaher
AU  - amr nady
AU  - Ibrahim Talaat
PY  - 2026
DA  - 2026/10/25
JO  - Minia Journal of Medical Research
DO  - 10.21608/mjmr.2026.537579.2408
UR  - https://doi.org/10.21608/mjmr.2026.537579.2408
AB  - Background  Dexmedetomidine is a selective alpha-2 adrenergic agonist used primarily for intravenous sedation in intensive care units and during surgical or diagnostic procedures.  Methods  This prospective randomized study was carried out on 90 adult patients aged 65 years and older who presented to the operating room for surgery under general anesthesia. Patients were divided into two equal groups. Group (A) received general anesthesia after infusion of normal saline, while group (B) received general anesthesia after a loading dose of dexmedetomidine 0.6 µg/kg.  Results  There was a statistically significant decrease in hemodynamic parameters observed in the two groups after induction of anesthesia. Dexmedetomidine administration resulted in a further significant decrease in these parameters when compared to the control group. These changes were not clinically significant, as the values remained within normal ranges. This effect may be beneficial in elderly patients undergoing surgery under general anesthesia.  Conclusion  Dexmedetomidine provided superior hemodynamic stability compared with the control group.
SN  - 2682-4558
ER  -