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Peer-reviewedCC BYJournal of Virology

H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves

  • Carine K. Souza1
  • Jefferson José da Silva Santos2
  • Paola Mercedes Boggiatto1
  • Haley M. Sterle1
  • Bailey L. Arruda1
  • Mitchell V. Palmer1
  • Alessandra Campos1
  • Jiaojiao Liu2
  • Naiqing Ye2
  • Drew Weissman3,4
  • Scott E. Hensley2
  • Amy L. Vincent Baker1
4 affiliations
  1. 1National Animal Disease Center – United States Department of Agriculture, Agricultural Research Service, Ames, IA, USA
  2. 2Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  3. 3Infection Disease Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  4. 4Penn Institute of RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Open at sourceDOICite

Abstract

Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 circulated widely in lactating dairy cows in the United States following the initial detection in 2024. Due to the critical need for intervention strategies for this outbreak, we evaluated antibody and cellular immune responses of a clade 2.3.4.4b H5 mRNA-LNP vaccine in calves. We found that the H5 mRNA-LNP vaccine induced a robust antibody and CD8 + T cell-mediated immune response and conferred protection against clade 2.3.4.4b H5N1 infection. IMPORTANCE It is important to develop vaccines that limit clade 2.3.4.4b H5N1 infection in cattle. In this study, we found that a new H5 mRNA-lipid nanoparticle vaccine is immunogenic when delivered intramuscularly to male Holstein calves.

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Cite

BibTeXRIS
BibTeX
@article{souza2026influenza,
  title = {{H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves}},
  author = {Carine K. Souza and Jefferson José da Silva Santos and Paola Mercedes Boggiatto and Haley M. Sterle and Bailey L. Arruda and Mitchell V. Palmer and Alessandra Campos and Jiaojiao Liu and Naiqing Ye and Drew Weissman and Scott E. Hensley and Amy L. Vincent Baker},
  journal = {Journal of Virology},
  year = {2026},
  month = oct,
  doi = {10.1128/jvi.01289-26},
  url = {https://doi.org/10.1128/jvi.01289-26},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves
AU  - Carine K. Souza
AU  - Jefferson José da Silva Santos
AU  - Paola Mercedes Boggiatto
AU  - Haley M. Sterle
AU  - Bailey L. Arruda
AU  - Mitchell V. Palmer
AU  - Alessandra Campos
AU  - Jiaojiao Liu
AU  - Naiqing Ye
AU  - Drew Weissman
AU  - Scott E. Hensley
AU  - Amy L. Vincent Baker
PY  - 2026
DA  - 2026/10/08
JO  - Journal of Virology
DO  - 10.1128/jvi.01289-26
UR  - https://doi.org/10.1128/jvi.01289-26
AB  - Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 circulated widely in lactating dairy cows in the United States following the initial detection in 2024. Due to the critical need for intervention strategies for this outbreak, we evaluated antibody and cellular immune responses of a clade 2.3.4.4b H5 mRNA-LNP vaccine in calves. We found that the H5 mRNA-LNP vaccine induced a robust antibody and CD8 + T cell-mediated immune response and conferred protection against clade 2.3.4.4b H5N1 infection. IMPORTANCE It is important to develop vaccines that limit clade 2.3.4.4b H5N1 infection in cattle. In this study, we found that a new H5 mRNA-lipid nanoparticle vaccine is immunogenic when delivered intramuscularly to male Holstein calves.
SN  - 0022-538X
SN  - 1070-6321
SN  - 1098-5514
ER  -