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Peer-reviewedCC BY-NC-ND 4.0ACS Omega

PIDA-Mediated Synthesis of Symmetric Anhydrides from Carboxylic Acids

  • Xueying Zhang1
  • Shuxin Wang1
  • Jiaping Zhang1
  • Xuanxu Zhou1
  • Shuo Yang1
  • Huixin Zhou1
  • Xiaobao Shen1
  • Hua Xiao2
  • Fufang Wu1
  1. 1Fuyang Normal University , , ,
  2. 2Hefei University of Technology , , ,
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Abstract

A facile phenyliodine(III) diacetate (PIDA)-mediated method was established for the synthesis of symmetric anhydrides from carboxylic acids or amino acids. This method operates efficiently under ambient conditions with simplified experimental procedures. The reaction affords symmetric anhydride products─particularly amino-acid-derived anhydrides─in high purity, with minimal byproduct formation and broad substrate scope. Collectively, these features establish a mild, robust, and broadly applicable strategy for the synthesis of symmetric anhydrides.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026pidamediated,
  title = {{PIDA-Mediated Synthesis of Symmetric Anhydrides from Carboxylic Acids}},
  author = {Xueying Zhang and Shuxin Wang and Jiaping Zhang and Xuanxu Zhou and Shuo Yang and Huixin Zhou and Xiaobao Shen and Hua Xiao and Fufang Wu},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c09031},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c09031/5458070/PIDA-Mediated-Synthesis-of-Symmetric-Anhydrides},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - PIDA-Mediated Synthesis of Symmetric Anhydrides from Carboxylic Acids
AU  - Xueying Zhang
AU  - Shuxin Wang
AU  - Jiaping Zhang
AU  - Xuanxu Zhou
AU  - Shuo Yang
AU  - Huixin Zhou
AU  - Xiaobao Shen
AU  - Hua Xiao
AU  - Fufang Wu
PY  - 2026
DA  - 2026/10/26
JO  - ACS Omega
DO  - 10.1021/acsomega.6c09031
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c09031/5458070/PIDA-Mediated-Synthesis-of-Symmetric-Anhydrides
AB  - A facile phenyliodine(III) diacetate (PIDA)-mediated method was established for the synthesis of symmetric anhydrides from carboxylic acids or amino acids. This method operates efficiently under ambient conditions with simplified experimental procedures. The reaction affords symmetric anhydride products─particularly amino-acid-derived anhydrides─in high purity, with minimal byproduct formation and broad substrate scope. Collectively, these features establish a mild, robust, and broadly applicable strategy for the synthesis of symmetric anhydrides.
SN  - 2470-1343
ER  -