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Peer-reviewedCC BY-NC 4.0Asian Pacific Journal of Cancer Prevention : APJCP

Pulmonary Rehabilitation for Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis

  • Shalini Ganesh Nayak1
  • Alwin Issac2
  • Prabhaker Mishra3
  • James Gonsalves4
4 affiliations
  1. 1Department of Medical Surgical Nursing, Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, India.
  2. 2College of Nursing, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
  3. 3Department of Biostatistics & Health Informatics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
  4. 4Department of Pathophysiology, American University of Antigua, College of Medicine, Antigua, India.
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Abstract

Objective:: Patients undergoing hematopoietic stem cell transfer experience various infectious and non-infectious complications, and pulmonary problems continue to be a leading cause of death and morbidity. This systematic review and meta-analysis aims to evaluate the effectiveness of pulmonary rehabilitation interventions on various pulmonary function parameters.

Methods:: We systematically searched for studies in PubMed, CINAHL, Embase, Cochrane, Scopus, Web of Science, ClinicalKey, and ProQuest for articles published in English from 2000 to 2024. Two reviewers independently identified the articles using key thesaurus terms and free-text terms based on the inclusion criteria. The review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Statement. Meta-analysis was performed using RevMan 5.3 software.

Results:: The systematic review included 18 trials, with a total of 1,052 participants, of whom 621 were from randomized controlled trials (RCTs) and the remaining 431 were from quasi-experimental studies. Pooled data from randomized controlled trials showed that pulmonary rehabilitation programs were effective in improving forced vital capacity (P < 0.001), FEV1/FVC (P = 0.004), maximal inspiratory pressure (P < 0.001), and dyspnoea (P = 0.03) at a statistically significant level.

Conclusion:: The evidence from the review suggests that pulmonary rehabilitation programmes are effective in improving certain parameters of pulmonary function. This systematic review and meta-analysis protocol was registered in PROSPERO with the registration number (CRD42024522354).

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Cite

BibTeXRIS
BibTeX
@article{nayak2026pulmonary,
  title = {{Pulmonary Rehabilitation for Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis}},
  author = {Shalini Ganesh Nayak and Alwin Issac and Prabhaker Mishra and James Gonsalves},
  journal = {Asian Pacific Journal of Cancer Prevention : APJCP},
  year = {2026},
  month = jun,
  doi = {10.31557/apjcp.2026.27.6.1957},
  url = {https://doi.org/10.31557/apjcp.2026.27.6.1957},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Pulmonary Rehabilitation for Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis
AU  - Shalini Ganesh Nayak
AU  - Alwin Issac
AU  - Prabhaker Mishra
AU  - James Gonsalves
PY  - 2026
DA  - 2026/06/18
JO  - Asian Pacific Journal of Cancer Prevention : APJCP
DO  - 10.31557/apjcp.2026.27.6.1957
UR  - https://doi.org/10.31557/apjcp.2026.27.6.1957
AB  - Objective:: Patients undergoing hematopoietic stem cell transfer experience various infectious and non-infectious complications, and pulmonary problems continue to be a leading cause of death and morbidity. This systematic review and meta-analysis aims to evaluate the effectiveness of pulmonary rehabilitation interventions on various pulmonary function parameters.  Methods:: We systematically searched for studies in PubMed, CINAHL, Embase, Cochrane, Scopus, Web of Science, ClinicalKey, and ProQuest for articles published in English from 2000 to 2024. Two reviewers independently identified the articles using key thesaurus terms and free-text terms based on the inclusion criteria. The review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Statement. Meta-analysis was performed using RevMan 5.3 software.  Results:: The systematic review included 18 trials, with a total of 1,052 participants, of whom 621 were from randomized controlled trials (RCTs) and the remaining 431 were from quasi-experimental studies. Pooled data from randomized controlled trials showed that pulmonary rehabilitation programs were effective in improving forced vital capacity (P < 0.001), FEV1/FVC (P = 0.004), maximal inspiratory pressure (P < 0.001), and dyspnoea (P = 0.03) at a statistically significant level.  Conclusion:: The evidence from the review suggests that pulmonary rehabilitation programmes are effective in improving certain parameters of pulmonary function. This systematic review and meta-analysis protocol was registered in PROSPERO with the registration number (CRD42024522354).
SN  - 1513-7368
SN  - 2476-762X
ER  -