Factors associated with acceptance of preventive treatment among older adults with latent tuberculosis infection in Huzhou, Zhejiang province: a cross-sectional study.
8 affiliations
- 1Department of HIV/TB Control and Prevention, Huzhou Center for Disease Control and Prevention, Huzhou, China.
- 2Department of Tuberculosis Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
- 3Department of Disease Control and Prevention, Huzhou Municipal Health Commission, Huzhou, China.
- 4Department of HIV/TB Control and Prevention, Wuxing District Center for Disease Control and Prevention, Huzhou, China.
- 5Department of HIV/TB Control and Prevention, Nanxun District Center for Disease Control and Prevention, Huzhou, China.
- 6Department of HIV/TB Control and Prevention, Deqing County Center for Disease Control and Prevention, Huzhou, China.
- 7Department of HIV/TB Control and Prevention, Changxing County Center for Disease Control and Prevention, Huzhou, China.
- 8Department of HIV/TB Control and Prevention, Anji County Center for Disease Control and Prevention, Huzhou, China.
Abstract
Objective
To investigate the acceptance of Tuberculosis preventive treatment (TPT) and the factors associated with treatment acceptance among individuals aged ≥60 years that screened positive for latent tuberculosis infection (LTBI) in Huzhou city, Zhejiang Province of China, and to provide scientific evidence for TPT implementation in this population.Methods
Older adults aged ≥60 years with LTBI were recruited through community-based health examinations and screening of close contacts of active tuberculosis patients. Univariate and multivariate Logistic regression analyses were performed to identify factors associated with TPT acceptance.Results
Of the 620 participants enrolled, 430 (69.35%) accepted TPT. Among the participants, 354 (57.09%) were male, 192 (30.96%) were aged over 70 years, 593 (95.65%) were married, 499 (80.48%) resided in rural areas, 577 (93.06%) had an education level of junior high school or below, 135 (21.77%) smoked daily or occasionally, and 152 (24.52%) consumed alcohol occasionally or at least twice weekly. Multivariate Logistic regression analysis revealed that participants with a household size of ≤3 persons (aOR: 1.88; 95% CI: 1.15-3.07), an annual household income of ≤150, 000 CNY (aOR: 2.24; 95% CI: 1.33-3.77), and a history of underlying diseases (aOR: 1.86; 95% CI: 1.16-2.99) were more likely to accept TPT.Conclusion
The TPT acceptance rate among older adults aged ≥60 years with LTBI in Huzhou was relatively high. Acceptance was independently associated with household structure, economic status, and health status. Smaller household size (≤3 persons), lower annual household income (≤150, 000 CNY), and the presence of underlying diseases were independently associated with TPT acceptance in this population. Targeted intervention strategies should be developed for older adults from larger households, those with better economic conditions, and those without underlying diseases to improve overall TPT coverage.
Related
- Determinants of willingness to accept Tuberculosis Preventive Treatment (TPT) among close contacts with Tuberculosis Infection (TBI) in Xinjiang, China
- Patient acceptance of preventive antibiotic treatment for tuberculosis: a qualitative study in London, UK
- The Impact of Isoniazid Preventive Therapy on Tuberculosis Infection and Disease Progression
- High Initiation but Suboptimal Completion of Tuberculosis-Preventive Treatment Among People Living With HIV on Antiretroviral Therapy, Persistent Tuberculosis Incidence, and Programmatic Implications: Findings From a 2-Year Multicountry Cohort Study
- Safety of tuberculosis-preventive treatment in children aged under 5 years: A rapid review.
BibTeX
@article{yang2026factors,
title = {{Factors associated with acceptance of preventive treatment among older adults with latent tuberculosis infection in Huzhou, Zhejiang province: a cross-sectional study.}},
author = {Zhongrong Yang and Zhipeng Zu and Xiuxiu Sun and XinYi Chen and Wei Wang and Pingming Zheng and Dong Wen and Feilin Ren and Zhongming Ding and Ming Gan and Hongyan Wang and Sichao Zhang and Yikun Kong and Guojun Jiang and Jianliang Fan and Jiasheng Qin and Jicun You and Meihua Jin and Bin Chen and Peng Zhang and Jianyong Shen},
journal = {Frontiers in cellular and infection microbiology},
year = {2026},
month = oct,
doi = {10.3389/fcimb.2026.1967858},
url = {https://europepmc.org/article/MED/42952506},
note = {CC BY},
}
RIS
TY - JOUR
TI - Factors associated with acceptance of preventive treatment among older adults with latent tuberculosis infection in Huzhou, Zhejiang province: a cross-sectional study.
AU - Zhongrong Yang
AU - Zhipeng Zu
AU - Xiuxiu Sun
AU - XinYi Chen
AU - Wei Wang
AU - Pingming Zheng
AU - Dong Wen
AU - Feilin Ren
AU - Zhongming Ding
AU - Ming Gan
AU - Hongyan Wang
AU - Sichao Zhang
AU - Yikun Kong
AU - Guojun Jiang
AU - Jianliang Fan
AU - Jiasheng Qin
AU - Jicun You
AU - Meihua Jin
AU - Bin Chen
AU - Peng Zhang
AU - Jianyong Shen
PY - 2026
DA - 2026/10/14
JO - Frontiers in cellular and infection microbiology
DO - 10.3389/fcimb.2026.1967858
UR - https://europepmc.org/article/MED/42952506
AB - Objective To investigate the acceptance of Tuberculosis preventive treatment (TPT) and the factors associated with treatment acceptance among individuals aged ≥60 years that screened positive for latent tuberculosis infection (LTBI) in Huzhou city, Zhejiang Province of China, and to provide scientific evidence for TPT implementation in this population.Methods Older adults aged ≥60 years with LTBI were recruited through community-based health examinations and screening of close contacts of active tuberculosis patients. Univariate and multivariate Logistic regression analyses were performed to identify factors associated with TPT acceptance.Results Of the 620 participants enrolled, 430 (69.35%) accepted TPT. Among the participants, 354 (57.09%) were male, 192 (30.96%) were aged over 70 years, 593 (95.65%) were married, 499 (80.48%) resided in rural areas, 577 (93.06%) had an education level of junior high school or below, 135 (21.77%) smoked daily or occasionally, and 152 (24.52%) consumed alcohol occasionally or at least twice weekly. Multivariate Logistic regression analysis revealed that participants with a household size of ≤3 persons (aOR: 1.88; 95% CI: 1.15-3.07), an annual household income of ≤150, 000 CNY (aOR: 2.24; 95% CI: 1.33-3.77), and a history of underlying diseases (aOR: 1.86; 95% CI: 1.16-2.99) were more likely to accept TPT.Conclusion The TPT acceptance rate among older adults aged ≥60 years with LTBI in Huzhou was relatively high. Acceptance was independently associated with household structure, economic status, and health status. Smaller household size (≤3 persons), lower annual household income (≤150, 000 CNY), and the presence of underlying diseases were independently associated with TPT acceptance in this population. Targeted intervention strategies should be developed for older adults from larger households, those with better economic conditions, and those without underlying diseases to improve overall TPT coverage.
SN - 2235-2988
ER -